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Risk to human and animal health related to the presence of 4,15-diacetoxyscirpenol in food and feed

(2018) EFSA JOURNAL. 16(8).
Author
Organization
Abstract
4,15-Diacetoxyscirpenol (DAS) is a mycotoxin primarily produced by Fusarium fungi and occurring predominantly in cereal grains. As requested by the European Commission, the EFSA Panelon Contaminants in the Food Chain (CONTAM) assessed the risk of DAS to human and animal health related to its presence in food and feed. Very limited information was available on toxicity and on toxicokinetics in experimental and farm animals. Due to the limitations in the available data set, human acute and chronic health-based guidance values (HBGV) were established based on data obtained in clinical trials of DAS as an anticancer agent (anguidine) after intravenous administration to cancer patients. The CONTAM Panelconsidered these data as informative for the hazard characterisation ofDAS after oral exposure. The main adverse effects after acute and repeated exposure were emesis,with a no-observed-adverse-effect level (NOAEL) of 32g DAS/kg body weight (bw), and haematotoxicity, with a NOAEL of 65g DAS/kg bw, respectively. An acute reference dose (ARfD) of 3.2 g DAS/kg bw and a tolerable daily intake (TDI) of 0.65 g DAS/kg bw were established. Based on over 15,000 occurrence data, the highest acute and chronic dietary exposures were estimated to be 0.8 and 0.49 g DAS/kg bw per day, respectively, and were not of health concern for humans. The limited information for poultry, pigs and dogs indicated a low risk for these animals at the estimated DAS exposure levels under current feeding practices, with the possible exception of fattening chicken. Assuming similar or lower sensitivity than for poultry, the risk was considered overall low for other farm and companion animal species for which no toxicity data were available. In consideration of the similarities of several trichothecenes and the likelihood of co-exposure via food and feed, it could be appropriate to perform a cumulative risk assessment for this group of substances.
Keywords
TANDEM MASS-SPECTROMETRY, TRICHOTHECENE MYCOTOXIN DIACETOXYSCIRPENOL, PERFORMANCE LIQUID-CHROMATOGRAPHY, CAPILLARY GAS-CHROMATOGRAPHY, IN-VITRO TOXICITY, LINKED-IMMUNOSORBENT-ASSAY, FLAME IONIZATION, DETECTION, SOUTHWEST-ONCOLOGY-GROUP, SOLID-PHASE EXTRACTION, 16 FUSARIUM, TOXINS, 4_15 - diacetoxyscirpenol, DAS, anguidine, MAS, exposure, toxicity, human and animal risk assessment

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Citation

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MLA
Knutsen, Helle Katrine, et al. “Risk to Human and Animal Health Related to the Presence of 4,15-Diacetoxyscirpenol in Food and Feed.” EFSA JOURNAL, vol. 16, no. 8, 2018.
APA
Knutsen, H. K., Alexander, J., Barregard, L., Bignami, M., Bruschweiler, B., Ceccatelli, S., … Edler, L. (2018). Risk to human and animal health related to the presence of 4,15-diacetoxyscirpenol in food and feed. EFSA JOURNAL, 16(8).
Chicago author-date
Knutsen, Helle Katrine, Jan Alexander, Lars Barregard, Margherita Bignami, Beat Bruschweiler, Sandra Ceccatelli, Bruce Cottrill, et al. 2018. “Risk to Human and Animal Health Related to the Presence of 4,15-Diacetoxyscirpenol in Food and Feed.” EFSA JOURNAL 16 (8).
Chicago author-date (all authors)
Knutsen, Helle Katrine, Jan Alexander, Lars Barregard, Margherita Bignami, Beat Bruschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Bettina Grasl-Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Carlo Stefano Nebbia, Isabelle P Oswald, Annette Petersen, Martin Rose, Alain-Claude Roudot, Tanja Schwerdtle, Christiane Vleminckx, Gunter Vollmer, Heather Wallace, Sarah De Saeger, Gunnar Sundstol Eriksen, Peter Farmer, Jean-Marc Fremy, Yun Yun Gong, Karsten Meyer, Dominique Parent-Massin, Hans Van Egmond, Andrea Altieri, Paolo Colombo, Zsuzsanna Horvath, Sara Levorato, and Lutz Edler. 2018. “Risk to Human and Animal Health Related to the Presence of 4,15-Diacetoxyscirpenol in Food and Feed.” EFSA JOURNAL 16 (8).
Vancouver
1.
Knutsen HK, Alexander J, Barregard L, Bignami M, Bruschweiler B, Ceccatelli S, et al. Risk to human and animal health related to the presence of 4,15-diacetoxyscirpenol in food and feed. EFSA JOURNAL. 2018;16(8).
IEEE
[1]
H. K. Knutsen et al., “Risk to human and animal health related to the presence of 4,15-diacetoxyscirpenol in food and feed,” EFSA JOURNAL, vol. 16, no. 8, 2018.
@article{8618300,
  abstract     = {4,15-Diacetoxyscirpenol (DAS) is a mycotoxin primarily produced by Fusarium fungi and occurring predominantly in cereal grains. As requested by the European Commission, the EFSA Panelon Contaminants in the Food Chain (CONTAM) assessed the risk of DAS to human and animal health related to its presence in food and feed. Very limited information was available on toxicity and on toxicokinetics in experimental and farm animals. Due to the limitations in the available data set, human acute and chronic health-based guidance values (HBGV) were established based on data obtained in clinical trials of DAS as an anticancer agent (anguidine) after intravenous administration to cancer patients. The CONTAM Panelconsidered these data as informative for the hazard characterisation ofDAS after oral exposure. The main adverse effects after acute and repeated exposure were emesis,with a no-observed-adverse-effect level (NOAEL) of 32g DAS/kg body weight (bw), and haematotoxicity, with a NOAEL of 65g DAS/kg bw, respectively. An acute reference dose (ARfD) of 3.2 g DAS/kg bw and a tolerable daily intake (TDI) of 0.65 g DAS/kg bw were established. Based on over 15,000 occurrence data, the highest acute and chronic dietary exposures were estimated to be 0.8 and 0.49 g DAS/kg bw per day, respectively, and were not of health concern for humans. The limited information for poultry, pigs and dogs indicated a low risk for these animals at the estimated DAS exposure levels under current feeding practices, with the possible exception of fattening chicken. Assuming similar or lower sensitivity than for poultry, the risk was considered overall low for other farm and companion animal species for which no toxicity data were available. In consideration of the similarities of several trichothecenes and the likelihood of co-exposure via food and feed, it could be appropriate to perform a cumulative risk assessment for this group of substances.},
  articleno    = {5367},
  author       = {Knutsen, Helle Katrine and Alexander, Jan and Barregard, Lars and Bignami, Margherita and Bruschweiler, Beat and Ceccatelli, Sandra and Cottrill, Bruce and Dinovi, Michael and Grasl-Kraupp, Bettina and Hogstrand, Christer and Hoogenboom, Laurentius (Ron) and Nebbia, Carlo Stefano and Oswald, Isabelle P and Petersen, Annette and Rose, Martin and Roudot, Alain-Claude and Schwerdtle, Tanja and Vleminckx, Christiane and Vollmer, Gunter and Wallace, Heather and De Saeger, Sarah and Eriksen, Gunnar Sundstol and Farmer, Peter and Fremy, Jean-Marc and Gong, Yun Yun and Meyer, Karsten and Parent-Massin, Dominique and Van Egmond, Hans and Altieri, Andrea and Colombo, Paolo and Horvath, Zsuzsanna and Levorato, Sara and Edler, Lutz},
  issn         = {1831-4732},
  journal      = {EFSA JOURNAL},
  keywords     = {TANDEM MASS-SPECTROMETRY,TRICHOTHECENE MYCOTOXIN DIACETOXYSCIRPENOL,PERFORMANCE LIQUID-CHROMATOGRAPHY,CAPILLARY GAS-CHROMATOGRAPHY,IN-VITRO TOXICITY,LINKED-IMMUNOSORBENT-ASSAY,FLAME IONIZATION,DETECTION,SOUTHWEST-ONCOLOGY-GROUP,SOLID-PHASE EXTRACTION,16 FUSARIUM,TOXINS,4_15 - diacetoxyscirpenol,DAS,anguidine,MAS,exposure,toxicity,human and animal risk assessment},
  language     = {eng},
  number       = {8},
  pages        = {106},
  title        = {Risk to human and animal health related to the presence of 4,15-diacetoxyscirpenol in food and feed},
  url          = {http://dx.doi.org/10.2903/j.efsa.2018.5367},
  volume       = {16},
  year         = {2018},
}

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