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Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

(2018) INFECTION. 46(5). p.687-691
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Abstract
PurposePre-clinical animal studies precede the majority of clinical trials. While the clinical sepsis definitions and recommended treatments are regularly updated, a systematic review of pre-clinical models of sepsis has not been done and clear modeling guidelines are lacking. To address this deficit, a Wiggers-Bernard Conference on pre-clinical sepsis modeling was held in Vienna in May, 2017. The conference goal was to identify limitations of pre-clinical sepsis models and to propose a set of guidelines, defined as the Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS), to enhance translational value of these models.Methods31 experts from 13 countries participated and were divided into 6 thematic Working Groups (WG): (1) Study Design, (2) Humane modeling, (3) Infection types, (4) Organ failure/dysfunction, (5) Fluid resuscitation and (6) Antimicrobial therapy endpoints. As basis for the MQTiPSS discussions, the participants conducted a literature review of the 260 most highly cited scientific articles on sepsis models (2002-2013).ResultsOverall, the participants reached consensus on 29 points; 20at recommendation (R) and 9at consideration (C) strength. This Executive Summary provides a synopsis of the MQTiPSS consensus (Tables1, 2 and 3).ConclusionsWe believe that these recommendations and considerations will serve to bring a level of standardization to pre-clinical models of sepsis and ultimately improve translation of pre-clinical findings. These guideline points are proposed as best practices that should be implemented for animal sepsis models. In order to encourage its wide dissemination, this article is freely accessible in Shock, Infection and Intensive Care Medicine Experimental.
Keywords
SHOCK, STANDARDS, THERAPIES, Guidelines, Experiment, Study design, Humane modeling, Infection types, Organ dysfunction, Fluid resuscitation, Antimicrobial therapy

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Chicago
Osuchowski, Marcin F., Alfred Ayala, Soheyl Bahrami, Michael Bauer, Mihaly Boros, Jean-Marc Cavaillon, Irshad H. Chaudry, et al. 2018. “Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis.” Infection 46 (5): 687–691.
APA
Osuchowski, M. F., Ayala, A., Bahrami, S., Bauer, M., Boros, M., Cavaillon, J.-M., Chaudry, I. H., et al. (2018). Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. INFECTION, 46(5), 687–691.
Vancouver
1.
Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon J-M, et al. Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis. INFECTION. Heidelberg: Springer Heidelberg; 2018;46(5):687–91.
MLA
Osuchowski, Marcin F. et al. “Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis.” INFECTION 46.5 (2018): 687–691. Print.
@article{8617554,
  abstract     = {PurposePre-clinical animal studies precede the majority of clinical trials. While the clinical sepsis definitions and recommended treatments are regularly updated, a systematic review of pre-clinical models of sepsis has not been done and clear modeling guidelines are lacking. To address this deficit, a Wiggers-Bernard Conference on pre-clinical sepsis modeling was held in Vienna in May, 2017. The conference goal was to identify limitations of pre-clinical sepsis models and to propose a set of guidelines, defined as the Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS), to enhance translational value of these models.Methods31 experts from 13 countries participated and were divided into 6 thematic Working Groups (WG): (1) Study Design, (2) Humane modeling, (3) Infection types, (4) Organ failure/dysfunction, (5) Fluid resuscitation and (6) Antimicrobial therapy endpoints. As basis for the MQTiPSS discussions, the participants conducted a literature review of the 260 most highly cited scientific articles on sepsis models (2002-2013).ResultsOverall, the participants reached consensus on 29 points; 20at recommendation (R) and 9at consideration (C) strength. This Executive Summary provides a synopsis of the MQTiPSS consensus (Tables1, 2 and 3).ConclusionsWe believe that these recommendations and considerations will serve to bring a level of standardization to pre-clinical models of sepsis and ultimately improve translation of pre-clinical findings. These guideline points are proposed as best practices that should be implemented for animal sepsis models. In order to encourage its wide dissemination, this article is freely accessible in Shock, Infection and Intensive Care Medicine Experimental.},
  author       = {Osuchowski, Marcin F. and Ayala, Alfred and Bahrami, Soheyl and Bauer, Michael and Boros, Mihaly and Cavaillon, Jean-Marc and Chaudry, Irshad H. and Coopersmith, Craig M. and Deutschman, Clifford and Drechsler, Susanne and Efron, Philip and Frostell, Claes and Fritsch, Gerhard and Gozdzik, Waldemar and Hellman, Judith and Huber-Lang, Markus and Inoue, Shigeaki and Knapp, Sylvia and Kozlov, Andrey V. and Libert, Claude and Marshall, John C. and Moldawer, Lyle L. and Radermacher, Peter and Redl, Heinz and Remick, Daniel G. and Singer, Mervyn and Thiemermann, Christoph and Wang, Ping and Wiersinga, W. Joost and Xiao, Xianzhong and Zingarelli, Basilia},
  issn         = {0300-8126},
  journal      = {INFECTION},
  keywords     = {SHOCK,STANDARDS,THERAPIES,Guidelines,Experiment,Study design,Humane modeling,Infection types,Organ dysfunction,Fluid resuscitation,Antimicrobial therapy},
  language     = {eng},
  number       = {5},
  pages        = {687--691},
  publisher    = {Springer Heidelberg},
  title        = {Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis},
  url          = {http://dx.doi.org/10.1007/s15010-018-1183-8},
  volume       = {46},
  year         = {2018},
}

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