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Forensic age estimation based on T1 SE and VIBE wrist MRI : do a one-fits-all staging technique and age estimation model apply?

(2019) EUROPEAN RADIOLOGY. 29(6). p.2924-2935
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Abstract
Objectives: Providing recommendations for wrist MRI in age estimation by determining (1) which anatomical structures to include in the statistical model, (2) which MRI sequence to conduct, and (3) which staging technique to apply. Methods: Radius and ulna were prospectively studied on 3T MRI in 363 healthy Caucasian participants (185 females, 178 males) between 14 and 26years old, using T1 spin echo (SE) and T1 gradient echo VIBE. Bone development was assessed applying a 5-stage staging technique with several amelioration attempts to optimise staging. A Bayesian model rendered point predictions of age and diagnostic indices to discern minors from adults. Results: All approaches rendered similar results, with none of them outperforming the others. A single bone assessment of radius or ulna sufficed. SE and VIBE sequences were both suitable, but needed sequence-specific age estimation. A one-fits-all 5-stage staging techniquewith substages in stage 3was suitable and did not benefit from profound substaging. Age estimation based on SE radius resulted in a mean absolute error of 1.79years, a specificity (correctly identified minors) of 93%, and a discrimination slope of 0.640. Conclusion: Radius and ulna perform similarly to estimate age, and so do SE and VIBE. A one-fits-all staging technique can be applied.Key Points center dot Radius and ulna perform similarly to estimate age.center dot SE and VIBE perform similarly, but age estimation should be based on the corresponding sequence-specific reference data.center dot A one-fits-all 5-stage staging technique with substages 3a, 3b, and 3c can be applied to both bones and both sequences.
Keywords
Age determination by skeleton, Wrist, Adolescent, Adult, Magnetic resonance imaging, DISTAL RADIAL EPIPHYSIS, MEDIAL CLAVICULAR EPIPHYSIS, SKELETAL AGE, BONE-AGE, HAND, OSSIFICATION, FOOTBALLERS, CARTILAGE, MATURITY, FUSION

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Citation

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Chicago
De Tobel, Jannick, Elke Hillewig, Michiel de Haas, Bram Van Eeckhout, Steffen Fieuws, Patrick Thevissen, and Koenraad Verstraete. 2019. “Forensic Age Estimation Based on T1 SE and VIBE Wrist MRI : Do a One-fits-all Staging Technique and Age Estimation Model Apply?” European Radiology 29 (6): 2924–2935.
APA
De Tobel, J., Hillewig, E., de Haas, M., Van Eeckhout, B., Fieuws, S., Thevissen, P., & Verstraete, K. (2019). Forensic age estimation based on T1 SE and VIBE wrist MRI : do a one-fits-all staging technique and age estimation model apply? EUROPEAN RADIOLOGY, 29(6), 2924–2935.
Vancouver
1.
De Tobel J, Hillewig E, de Haas M, Van Eeckhout B, Fieuws S, Thevissen P, et al. Forensic age estimation based on T1 SE and VIBE wrist MRI : do a one-fits-all staging technique and age estimation model apply? EUROPEAN RADIOLOGY. 2019;29(6):2924–35.
MLA
De Tobel, Jannick et al. “Forensic Age Estimation Based on T1 SE and VIBE Wrist MRI : Do a One-fits-all Staging Technique and Age Estimation Model Apply?” EUROPEAN RADIOLOGY 29.6 (2019): 2924–2935. Print.
@article{8617518,
  abstract     = {Objectives: Providing recommendations for wrist MRI in age estimation by determining (1) which anatomical structures to include in the statistical model, (2) which MRI sequence to conduct, and (3) which staging technique to apply.
Methods: Radius and ulna were prospectively studied on 3T MRI in 363 healthy Caucasian participants (185 females, 178 males) between 14 and 26years old, using T1 spin echo (SE) and T1 gradient echo VIBE. Bone development was assessed applying a 5-stage staging technique with several amelioration attempts to optimise staging. A Bayesian model rendered point predictions of age and diagnostic indices to discern minors from adults.
Results: All approaches rendered similar results, with none of them outperforming the others. A single bone assessment of radius or ulna sufficed. SE and VIBE sequences were both suitable, but needed sequence-specific age estimation. A one-fits-all 5-stage staging techniquewith substages in stage 3was suitable and did not benefit from profound substaging. Age estimation based on SE radius resulted in a mean absolute error of 1.79years, a specificity (correctly identified minors) of 93%, and a discrimination slope of 0.640.
Conclusion: Radius and ulna perform similarly to estimate age, and so do SE and VIBE. A one-fits-all staging technique can be applied.Key Points center dot Radius and ulna perform similarly to estimate age.center dot SE and VIBE perform similarly, but age estimation should be based on the corresponding sequence-specific reference data.center dot A one-fits-all 5-stage staging technique with substages 3a, 3b, and 3c can be applied to both bones and both sequences.},
  author       = {De Tobel, Jannick and Hillewig, Elke and de Haas, Michiel and Van Eeckhout, Bram and Fieuws, Steffen and Thevissen, Patrick and Verstraete, Koenraad},
  issn         = {0938-7994},
  journal      = {EUROPEAN RADIOLOGY},
  keywords     = {Age determination by skeleton,Wrist,Adolescent,Adult,Magnetic resonance imaging,DISTAL RADIAL EPIPHYSIS,MEDIAL CLAVICULAR EPIPHYSIS,SKELETAL AGE,BONE-AGE,HAND,OSSIFICATION,FOOTBALLERS,CARTILAGE,MATURITY,FUSION},
  language     = {eng},
  number       = {6},
  pages        = {2924--2935},
  title        = {Forensic age estimation based on T1 SE and VIBE wrist MRI : do a one-fits-all staging technique and age estimation model apply?},
  url          = {http://dx.doi.org/10.1007/s00330-018-5944-7},
  volume       = {29},
  year         = {2019},
}

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