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Gas‐shearing fabrication of multicompartmental microspheres : a one‐step and oil‐free approach

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Abstract
Multicompartmental microparticles (MCMs) have attracted considerable attention in biomedical engineering and materials sciences, as they can carry multiple materials in the separated phases of a single particle. However, the robust fabrication of monodisperse, highly compartmental MCMs at the micro- and nanoscales remains challenging. Here, a simple one-step and oil-free process, based on the gas-flow-assisted formation of microdroplets ("gas-shearing"), is established for the scalable production of monodisperse MCMs. By changing the configuration of the needle system and gas flow in the spray ejector device, the oil-free gas-shearing process easily allows the design of microparticles consisting of two, four, six, and even eight compartments with a precise control over the properties of each compartment. As oils and surfactants are not used, the gas-shearing method is highly cytocompatible. The versatile applications of such MCMs are demonstrated by producing a magnetic microrobot and a biocompatible carrier for the coculturing of cells. This research suggests that the oil-free gas-shearing strategy is a reliable, scalable, and biofriendly process for producing MCMs that may become attractive materials for biomedical applications.
Keywords
biocompatible carriers, gas-shearing, multicompartmental microspheres, one-step fabrication, tissue engineering

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Chicago
Tang, Guosheng, Ranhua Xiong, Dan Lv, Ronald X. Xu, Kevin Braeckmans, Chaobo Huang, and Stefaan De Smedt. 2019. “Gas‐shearing Fabrication of Multicompartmental Microspheres : a One‐step and Oil‐free Approach.” Advanced Science 6 (9).
APA
Tang, G., Xiong, R., Lv, D., Xu, R. X., Braeckmans, K., Huang, C., & De Smedt, S. (2019). Gas‐shearing fabrication of multicompartmental microspheres : a one‐step and oil‐free approach. ADVANCED SCIENCE, 6(9).
Vancouver
1.
Tang G, Xiong R, Lv D, Xu RX, Braeckmans K, Huang C, et al. Gas‐shearing fabrication of multicompartmental microspheres : a one‐step and oil‐free approach. ADVANCED SCIENCE. Wiley; 2019;6(9).
MLA
Tang, Guosheng et al. “Gas‐shearing Fabrication of Multicompartmental Microspheres : a One‐step and Oil‐free Approach.” ADVANCED SCIENCE 6.9 (2019): n. pag. Print.
@article{8617470,
  abstract     = {Multicompartmental microparticles (MCMs) have attracted considerable attention in biomedical engineering and materials sciences, as they can carry multiple materials in the separated phases of a single particle. However, the robust fabrication of monodisperse, highly compartmental MCMs at the micro- and nanoscales remains challenging. Here, a simple one-step and oil-free process, based on the gas-flow-assisted formation of microdroplets ("gas-shearing"), is established for the scalable production of monodisperse MCMs. By changing the configuration of the needle system and gas flow in the spray ejector device, the oil-free gas-shearing process easily allows the design of microparticles consisting of two, four, six, and even eight compartments with a precise control over the properties of each compartment. As oils and surfactants are not used, the gas-shearing method is highly cytocompatible. The versatile applications of such MCMs are demonstrated by producing a magnetic microrobot and a biocompatible carrier for the coculturing of cells. This research suggests that the oil-free gas-shearing strategy is a reliable, scalable, and biofriendly process for producing MCMs that may become attractive materials for biomedical applications.},
  articleno    = {1802342},
  author       = {Tang, Guosheng and Xiong, Ranhua and Lv, Dan and Xu, Ronald X. and Braeckmans, Kevin and Huang, Chaobo and De Smedt, Stefaan},
  issn         = {2198-3844},
  journal      = {ADVANCED SCIENCE},
  keywords     = {biocompatible carriers,gas-shearing,multicompartmental microspheres,one-step fabrication,tissue engineering},
  language     = {eng},
  number       = {9},
  publisher    = {Wiley},
  title        = {Gas‐shearing fabrication of multicompartmental microspheres : a one‐step and oil‐free approach},
  url          = {http://dx.doi.org/10.1002/advs.201802342},
  volume       = {6},
  year         = {2019},
}

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