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Cytokine removal in human septic shock : where are we and where are we going?

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Abstract
Although improving, the mortality from septic shock still remains high despite increased international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort to improve outcomes. The application of blood purification therapies to improve immune homeostasis has been suggested as one such method, but these approaches, such as high-volume continuous haemofiltration or cytokine and/or endotoxin removal, have enjoyed little success to date. More recently, the use of sorbent technologies has attracted much attention. These adsorbers are highly effective at removing inflammatory mediators, in particular, cytokines, from the bloodstream. This narrative review is the executive summary of meetings held throughout the 6th International Fluid Academy Days in Antwerp, Belgium (Nov 23-25, 2017), focusing on the current understanding regarding the use of such adsorbers in humans with septic shock. We followed a modified Delphi approach involving a combination of evidence appraisal together with expert opinion in order to achieve recommendations for practice and, importantly, future research.
Keywords
Blood purification, Cytokines, Sepsis, Septic shock, Haemoperfusion, Cytosorb, Sorbents, Cartridges, Immune modulation, DAMPS, PAMPS, POLYMYXIN-B HEMOPERFUSION, CRITICALLY-ILL PATIENTS, INTENSIVE-CARE UNITS, SHORT-TERM SURVIVAL, SEVERE SEPSIS, HIGH-VOLUME, BLOOD PURIFICATION, DR EXPRESSION, IN-VIVO, MORTALITY

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MLA
Honore, Patrick M et al. “Cytokine Removal in Human Septic Shock : Where Are We and Where Are We Going?” ANNALS OF INTENSIVE CARE 9.1 (2019): n. pag. Print.
APA
Honore, P. M., Hoste, E., Molnár, Z., Jacobs, R., Joannes-Boyau, O., Malbrain, M. L., & Forni, L. G. (2019). Cytokine removal in human septic shock : where are we and where are we going? ANNALS OF INTENSIVE CARE, 9(1).
Chicago author-date
Honore, Patrick M, Eric Hoste, Zsolt Molnár, Rita Jacobs, Olivier Joannes-Boyau, Manu LNG Malbrain, and Lui G Forni. 2019. “Cytokine Removal in Human Septic Shock : Where Are We and Where Are We Going?” Annals of Intensive Care 9 (1).
Chicago author-date (all authors)
Honore, Patrick M, Eric Hoste, Zsolt Molnár, Rita Jacobs, Olivier Joannes-Boyau, Manu LNG Malbrain, and Lui G Forni. 2019. “Cytokine Removal in Human Septic Shock : Where Are We and Where Are We Going?” Annals of Intensive Care 9 (1).
Vancouver
1.
Honore PM, Hoste E, Molnár Z, Jacobs R, Joannes-Boyau O, Malbrain ML, et al. Cytokine removal in human septic shock : where are we and where are we going? ANNALS OF INTENSIVE CARE. 2019;9(1).
IEEE
[1]
P. M. Honore et al., “Cytokine removal in human septic shock : where are we and where are we going?,” ANNALS OF INTENSIVE CARE, vol. 9, no. 1, 2019.
@article{8617098,
  abstract     = {Although improving, the mortality from septic shock still remains high despite increased international awareness. As a consequence, much effort has focused on alternative treatment strategies in an effort to improve outcomes. The application of blood purification therapies to improve immune homeostasis has been suggested as one such method, but these approaches, such as high-volume continuous haemofiltration or cytokine and/or endotoxin removal, have enjoyed little success to date. More recently, the use of sorbent technologies has attracted much attention. These adsorbers are highly effective at removing inflammatory mediators, in particular, cytokines, from the bloodstream. This narrative review is the executive summary of meetings held throughout the 6th International Fluid Academy Days in Antwerp, Belgium (Nov 23-25, 2017), focusing on the current understanding regarding the use of such adsorbers in humans with septic shock. We followed a modified Delphi approach involving a combination of evidence appraisal together with expert opinion in order to achieve recommendations for practice and, importantly, future research.},
  articleno    = {56},
  author       = {Honore, Patrick M and Hoste, Eric and Molnár, Zsolt and Jacobs, Rita and Joannes-Boyau, Olivier and Malbrain, Manu LNG and Forni, Lui G},
  issn         = {2110-5820},
  journal      = {ANNALS OF INTENSIVE CARE},
  keywords     = {Blood purification,Cytokines,Sepsis,Septic shock,Haemoperfusion,Cytosorb,Sorbents,Cartridges,Immune modulation,DAMPS,PAMPS,POLYMYXIN-B HEMOPERFUSION,CRITICALLY-ILL PATIENTS,INTENSIVE-CARE UNITS,SHORT-TERM SURVIVAL,SEVERE SEPSIS,HIGH-VOLUME,BLOOD PURIFICATION,DR EXPRESSION,IN-VIVO,MORTALITY},
  language     = {eng},
  number       = {1},
  pages        = {13},
  title        = {Cytokine removal in human septic shock : where are we and where are we going?},
  url          = {http://dx.doi.org/10.1186/s13613-019-0530-y},
  volume       = {9},
  year         = {2019},
}

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