- Author
- Daolin Tang, Rui Kang, Tom Vanden Berghe (UGent) , Peter Vandenabeele (UGent) and Guido Kroemer
- Organization
- Abstract
- Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.
- Keywords
- MIXED LINEAGE KINASE, DOMAIN-LIKE PROTEIN, NF-KAPPA-B, NONCANONICAL, INFLAMMASOME ACTIVATION, TUMOR-NECROSIS-FACTOR, GASDERMIN-D, PROGRAMMED, NECROSIS, AIM2 INFLAMMASOME, OXIDATIVE STRESS, NOMENCLATURE COMMITTEE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8616364
- MLA
- Tang, Daolin, et al. “The Molecular Machinery of Regulated Cell Death.” CELL RESEARCH, vol. 29, no. 5, 2019, pp. 347–64, doi:10.1038/s41422-019-0164-5.
- APA
- Tang, D., Kang, R., Vanden Berghe, T., Vandenabeele, P., & Kroemer, G. (2019). The molecular machinery of regulated cell death. CELL RESEARCH, 29(5), 347–364. https://doi.org/10.1038/s41422-019-0164-5
- Chicago author-date
- Tang, Daolin, Rui Kang, Tom Vanden Berghe, Peter Vandenabeele, and Guido Kroemer. 2019. “The Molecular Machinery of Regulated Cell Death.” CELL RESEARCH 29 (5): 347–64. https://doi.org/10.1038/s41422-019-0164-5.
- Chicago author-date (all authors)
- Tang, Daolin, Rui Kang, Tom Vanden Berghe, Peter Vandenabeele, and Guido Kroemer. 2019. “The Molecular Machinery of Regulated Cell Death.” CELL RESEARCH 29 (5): 347–364. doi:10.1038/s41422-019-0164-5.
- Vancouver
- 1.Tang D, Kang R, Vanden Berghe T, Vandenabeele P, Kroemer G. The molecular machinery of regulated cell death. CELL RESEARCH. 2019;29(5):347–64.
- IEEE
- [1]D. Tang, R. Kang, T. Vanden Berghe, P. Vandenabeele, and G. Kroemer, “The molecular machinery of regulated cell death,” CELL RESEARCH, vol. 29, no. 5, pp. 347–364, 2019.
@article{8616364,
abstract = {{Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.}},
author = {{Tang, Daolin and Kang, Rui and Vanden Berghe, Tom and Vandenabeele, Peter and Kroemer, Guido}},
issn = {{1001-0602}},
journal = {{CELL RESEARCH}},
keywords = {{MIXED LINEAGE KINASE,DOMAIN-LIKE PROTEIN,NF-KAPPA-B,NONCANONICAL,INFLAMMASOME ACTIVATION,TUMOR-NECROSIS-FACTOR,GASDERMIN-D,PROGRAMMED,NECROSIS,AIM2 INFLAMMASOME,OXIDATIVE STRESS,NOMENCLATURE COMMITTEE}},
language = {{eng}},
number = {{5}},
pages = {{347--364}},
title = {{The molecular machinery of regulated cell death}},
url = {{http://doi.org/10.1038/s41422-019-0164-5}},
volume = {{29}},
year = {{2019}},
}
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