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The molecular machinery of regulated cell death

(2019) CELL RESEARCH. 29(5). p.347-364
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Abstract
Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.
Keywords
MIXED LINEAGE KINASE, DOMAIN-LIKE PROTEIN, NF-KAPPA-B, NONCANONICAL, INFLAMMASOME ACTIVATION, TUMOR-NECROSIS-FACTOR, GASDERMIN-D, PROGRAMMED, NECROSIS, AIM2 INFLAMMASOME, OXIDATIVE STRESS, NOMENCLATURE COMMITTEE

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Citation

Please use this url to cite or link to this publication:

Chicago
Tang, Daolin, Rui Kang, Tom Vanden Berghe, Peter Vandenabeele, and Guido Kroemer. 2019. “The Molecular Machinery of Regulated Cell Death.” Cell Research 29 (5): 347–364.
APA
Tang, D., Kang, R., Vanden Berghe, T., Vandenabeele, P., & Kroemer, G. (2019). The molecular machinery of regulated cell death. CELL RESEARCH, 29(5), 347–364.
Vancouver
1.
Tang D, Kang R, Vanden Berghe T, Vandenabeele P, Kroemer G. The molecular machinery of regulated cell death. CELL RESEARCH. London: Nature Publishing Group; 2019;29(5):347–64.
MLA
Tang, Daolin et al. “The Molecular Machinery of Regulated Cell Death.” CELL RESEARCH 29.5 (2019): 347–364. Print.
@article{8616364,
  abstract     = {Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.},
  author       = {Tang, Daolin and Kang, Rui and Vanden Berghe, Tom and Vandenabeele, Peter and Kroemer, Guido},
  issn         = {1001-0602},
  journal      = {CELL RESEARCH},
  language     = {eng},
  number       = {5},
  pages        = {347--364},
  publisher    = {Nature Publishing Group},
  title        = {The molecular machinery of regulated cell death},
  url          = {http://dx.doi.org/10.1038/s41422-019-0164-5},
  volume       = {29},
  year         = {2019},
}

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