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The molecular machinery of regulated cell death

(2019) CELL RESEARCH. 29(5). p.347-364
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Abstract
Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.
Keywords
MIXED LINEAGE KINASE, DOMAIN-LIKE PROTEIN, NF-KAPPA-B, NONCANONICAL, INFLAMMASOME ACTIVATION, TUMOR-NECROSIS-FACTOR, GASDERMIN-D, PROGRAMMED, NECROSIS, AIM2 INFLAMMASOME, OXIDATIVE STRESS, NOMENCLATURE COMMITTEE

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Citation

Please use this url to cite or link to this publication:

MLA
Tang, Daolin et al. “The Molecular Machinery of Regulated Cell Death.” CELL RESEARCH 29.5 (2019): 347–364. Print.
APA
Tang, Daolin, Kang, R., Vanden Berghe, T., Vandenabeele, P., & Kroemer, G. (2019). The molecular machinery of regulated cell death. CELL RESEARCH, 29(5), 347–364.
Chicago author-date
Tang, Daolin, Rui Kang, Tom Vanden Berghe, Peter Vandenabeele, and Guido Kroemer. 2019. “The Molecular Machinery of Regulated Cell Death.” Cell Research 29 (5): 347–364.
Chicago author-date (all authors)
Tang, Daolin, Rui Kang, Tom Vanden Berghe, Peter Vandenabeele, and Guido Kroemer. 2019. “The Molecular Machinery of Regulated Cell Death.” Cell Research 29 (5): 347–364.
Vancouver
1.
Tang D, Kang R, Vanden Berghe T, Vandenabeele P, Kroemer G. The molecular machinery of regulated cell death. CELL RESEARCH. 2019;29(5):347–64.
IEEE
[1]
D. Tang, R. Kang, T. Vanden Berghe, P. Vandenabeele, and G. Kroemer, “The molecular machinery of regulated cell death,” CELL RESEARCH, vol. 29, no. 5, pp. 347–364, 2019.
@article{8616364,
  abstract     = {Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel non-apoptotic forms of RCD have been identified and are increasingly being implicated in various human pathologies. Here, we critically review the current state of the art regarding non-apoptotic types of RCD, including necroptosis, pyroptosis, ferroptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis and oxeiptosis. The in-depth comprehension of each of these lethal subroutines and their intercellular consequences may uncover novel therapeutic targets for the avoidance of pathogenic cell loss.},
  author       = {Tang, Daolin and Kang, Rui and Vanden Berghe, Tom and Vandenabeele, Peter and Kroemer, Guido},
  issn         = {1001-0602},
  journal      = {CELL RESEARCH},
  keywords     = {MIXED LINEAGE KINASE,DOMAIN-LIKE PROTEIN,NF-KAPPA-B,NONCANONICAL,INFLAMMASOME ACTIVATION,TUMOR-NECROSIS-FACTOR,GASDERMIN-D,PROGRAMMED,NECROSIS,AIM2 INFLAMMASOME,OXIDATIVE STRESS,NOMENCLATURE COMMITTEE},
  language     = {eng},
  number       = {5},
  pages        = {347--364},
  title        = {The molecular machinery of regulated cell death},
  url          = {http://dx.doi.org/10.1038/s41422-019-0164-5},
  volume       = {29},
  year         = {2019},
}

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