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ZEBs: Novel Players in Immune Cell Development and Function

(2019) TRENDS IN IMMUNOLOGY. 40(5). p.431-446
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Abstract
ZEB1 and ZEB2 are zinc-finger E homeobox-binding transcription factors best known for their role in driving epithelial to mesenchymal transition. However, in recent years our understanding of these two transcription factors has broadened, and it is now clear that they are expressed by a variety of immune cells of both myeloid and lymphoid lineages, including dendritic cells, macrophages, monocytes, B, T, and NK cells. In these cells, ZEBs function to regulate important transcriptional networks necessary for cell differentiation, maintenance, and function. Here, we review the current understanding of ZEB regulation across immune cell lineages, particularly in mice, highlighting present gaps in our knowledge. We also speculate on important questions for the future.
Keywords
PLASMACYTOID DENDRITIC CELL, TRANSCRIPTION FACTOR E2-2, T-BET, TERMINAL, DIFFERENTIATION, CD8(+) EFFECTOR, EXPRESSION, ID2, IDENTIFICATION, PROGRAM, GENE

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Citation

Please use this url to cite or link to this publication:

Chicago
Scott, Charlotte, and Kyla D. Omilusik. 2019. “ZEBs: Novel Players in Immune Cell Development and Function.” Trends in Immunology 40 (5): 431–446.
APA
Scott, C., & Omilusik, K. D. (2019). ZEBs: Novel Players in Immune Cell Development and Function. TRENDS IN IMMUNOLOGY, 40(5), 431–446.
Vancouver
1.
Scott C, Omilusik KD. ZEBs: Novel Players in Immune Cell Development and Function. TRENDS IN IMMUNOLOGY. Oxford: Elsevier Sci Ltd; 2019;40(5):431–46.
MLA
Scott, Charlotte, and Kyla D. Omilusik. “ZEBs: Novel Players in Immune Cell Development and Function.” TRENDS IN IMMUNOLOGY 40.5 (2019): 431–446. Print.
@article{8616357,
  abstract     = {ZEB1 and ZEB2 are zinc-finger E homeobox-binding transcription factors best known for their role in driving epithelial to mesenchymal transition. However, in recent years our understanding of these two transcription factors has broadened, and it is now clear that they are expressed by a variety of immune cells of both myeloid and lymphoid lineages, including dendritic cells, macrophages, monocytes, B, T, and NK cells. In these cells, ZEBs function to regulate important transcriptional networks necessary for cell differentiation, maintenance, and function. Here, we review the current understanding of ZEB regulation across immune cell lineages, particularly in mice, highlighting present gaps in our knowledge. We also speculate on important questions for the future.},
  author       = {Scott, Charlotte and Omilusik, Kyla D.},
  issn         = {1471-4906},
  journal      = {TRENDS IN IMMUNOLOGY},
  language     = {eng},
  number       = {5},
  pages        = {431--446},
  publisher    = {Elsevier Sci Ltd},
  title        = {ZEBs: Novel Players in Immune Cell Development and Function},
  url          = {http://dx.doi.org/10.1016/j.it.2019.03.001},
  volume       = {40},
  year         = {2019},
}

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