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Poly(D, L-lactic acid) (PDLLA) biodegradable and biocompatible polymer optical fiber

(2019) JOURNAL OF LIGHTWAVE TECHNOLOGY. 37(9). p.1916-1923
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Abstract
We demonstrate that commercially available poly(D, L-lactic acid) (PDLLA) is a suitable material for the fabrication of biodegradable optical fibers with a standard heat drawing process. To do so we report on the chemical and optical characterization of the material. We address the influence of the polymer processing on the molecular weight and thermal properties of the polymer following the preparation of the polymer preforms and the fiber optic drawing process. We show that cutback measurements of the first optical fibers drawn fromPDLLA return an attenuation coefficient as low as 0.11 dB/cm at 772 nm, which is the lowest loss reported this far for optical fibers drawn from bio-resorbable material. We also report on the dispersion characteristics of PDLLA, and we find that the thermo-optic coefficient is in the range of -10-4 degrees C-1. Finally, we studied the degradation of PDLLA fibers in vitro, revealing that fibers with the largest diameter of 600 mu m degrade faster than those with smaller diameters of 300 and 200 mu m and feature more than 84% molecular weight loss over a period of 3 months. The evolution of the optical loss of the fibers as a function of time during immersion in phosphate-buffered saline indicates that these devices are potential candidates for use in photodynamic therapy-like application scenarios.
Keywords
THERMOOPTICAL COEFFICIENTS, DEGRADATION, LIGHT, Biodegradable materials, optical polymers, plastic optical fiber

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MLA
Gierej, Agnieszka, et al. “Poly(D, L-Lactic Acid) (PDLLA) Biodegradable and Biocompatible Polymer Optical Fiber.” JOURNAL OF LIGHTWAVE TECHNOLOGY, vol. 37, no. 9, 2019, pp. 1916–23, doi:10.1109/JLT.2019.2895220.
APA
Gierej, A., Vagenende, M., Filipkowski, A., Siwicki, B., Buczynski, R., Thienpont, H., … Berghmans, F. (2019). Poly(D, L-lactic acid) (PDLLA) biodegradable and biocompatible polymer optical fiber. JOURNAL OF LIGHTWAVE TECHNOLOGY, 37(9), 1916–1923. https://doi.org/10.1109/JLT.2019.2895220
Chicago author-date
Gierej, Agnieszka, Maxime Vagenende, Adam Filipkowski, Bartlotniej Siwicki, Ryszard Buczynski, Hugo Thienpont, Sandra Van Vlierberghe, Thomas Geernaert, Peter Dubruel, and Francis Berghmans. 2019. “Poly(D, L-Lactic Acid) (PDLLA) Biodegradable and Biocompatible Polymer Optical Fiber.” JOURNAL OF LIGHTWAVE TECHNOLOGY 37 (9): 1916–23. https://doi.org/10.1109/JLT.2019.2895220.
Chicago author-date (all authors)
Gierej, Agnieszka, Maxime Vagenende, Adam Filipkowski, Bartlotniej Siwicki, Ryszard Buczynski, Hugo Thienpont, Sandra Van Vlierberghe, Thomas Geernaert, Peter Dubruel, and Francis Berghmans. 2019. “Poly(D, L-Lactic Acid) (PDLLA) Biodegradable and Biocompatible Polymer Optical Fiber.” JOURNAL OF LIGHTWAVE TECHNOLOGY 37 (9): 1916–1923. doi:10.1109/JLT.2019.2895220.
Vancouver
1.
Gierej A, Vagenende M, Filipkowski A, Siwicki B, Buczynski R, Thienpont H, et al. Poly(D, L-lactic acid) (PDLLA) biodegradable and biocompatible polymer optical fiber. JOURNAL OF LIGHTWAVE TECHNOLOGY. 2019;37(9):1916–23.
IEEE
[1]
A. Gierej et al., “Poly(D, L-lactic acid) (PDLLA) biodegradable and biocompatible polymer optical fiber,” JOURNAL OF LIGHTWAVE TECHNOLOGY, vol. 37, no. 9, pp. 1916–1923, 2019.
@article{8615157,
  abstract     = {{We demonstrate that commercially available poly(D, L-lactic acid) (PDLLA) is a suitable material for the fabrication of biodegradable optical fibers with a standard heat drawing process. To do so we report on the chemical and optical characterization of the material. We address the influence of the polymer processing on the molecular weight and thermal properties of the polymer following the preparation of the polymer preforms and the fiber optic drawing process. We show that cutback measurements of the first optical fibers drawn fromPDLLA return an attenuation coefficient as low as 0.11 dB/cm at 772 nm, which is the lowest loss reported this far for optical fibers drawn from bio-resorbable material. We also report on the dispersion characteristics of PDLLA, and we find that the thermo-optic coefficient is in the range of -10-4 degrees C-1. Finally, we studied the degradation of PDLLA fibers in vitro, revealing that fibers with the largest diameter of 600 mu m degrade faster than those with smaller diameters of 300 and 200 mu m and feature more than 84% molecular weight loss over a period of 3 months. The evolution of the optical loss of the fibers as a function of time during immersion in phosphate-buffered saline indicates that these devices are potential candidates for use in photodynamic therapy-like application scenarios.}},
  author       = {{Gierej, Agnieszka and Vagenende, Maxime and Filipkowski, Adam and Siwicki, Bartlotniej and Buczynski, Ryszard and Thienpont, Hugo and Van Vlierberghe, Sandra and Geernaert, Thomas and Dubruel, Peter and Berghmans, Francis}},
  issn         = {{0733-8724}},
  journal      = {{JOURNAL OF LIGHTWAVE TECHNOLOGY}},
  keywords     = {{THERMOOPTICAL COEFFICIENTS,DEGRADATION,LIGHT,Biodegradable materials,optical polymers,plastic optical fiber}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1916--1923}},
  title        = {{Poly(D, L-lactic acid) (PDLLA) biodegradable and biocompatible polymer optical fiber}},
  url          = {{http://dx.doi.org/10.1109/JLT.2019.2895220}},
  volume       = {{37}},
  year         = {{2019}},
}

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