Advanced search
1 file | 283.16 KB

Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response

(2006) INFECTION AND IMMUNITY. 74(11). p.6324-6330
Author
Organization
Abstract
Tsetse flies (Glossina sp.) are the vectors that transmit African trypanosomes, protozoan parasites that cause human sleeping sickness and veterinary infections in the African continent. These blood-feeding dipteran insects deposit saliva at the feeding site that enables the blood-feeding process. Here we demonstrate that tsetse fly saliva also accelerates the onset of a Trypanosoma brucei infection. This effect was associated with a reduced inflammatory reaction at the site of infection initiation (reflected by a decrease of interleukin-6 [IL-6] and IL-12 mRNA) as well as lower serum concentrations of the trypanocidal cytokine tumor necrosis factor. Variant-specific surface glycoprotein-specific antibody isotypes immunoglobulin M (IgM) and IgG2a, implicated in trypanosome clearance, were not suppressed. We propose that tsetse fly saliva accelerates the onset of trypanosome infection by inhibiting local and systemic inflammatory responses involved in parasite control.
Keywords
ALTERNATIVE COMPLEMENT PATHWAY, TUMOR-NECROSIS-FACTOR, IXODES-RICINUS TICKS, IMMUNE-RESPONSE, GLAND EXTRACT, AFRICAN TRYPANOSOMES, LEISHMANIA-MAJOR, VECTOR SALIVA, CUTANEOUS LEISHMANIASIS, ACTIVATED MACROPHAGES

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 283.16 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Caljon, Guy, Jan Van Den Abbeele, Benoit Stijlemans, Marc Coosemans, Patrick De Baetselier, and Stefan Magez. 2006. “Tsetse Fly Saliva Accelerates the Onset of Trypanosoma Brucei Infection in a Mouse Model Associated with a Reduced Host Inflammatory Response.” Infection and Immunity 74 (11): 6324–6330.
APA
Caljon, Guy, Van Den Abbeele, J., Stijlemans, B., Coosemans, M., De Baetselier, P., & Magez, S. (2006). Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response. INFECTION AND IMMUNITY, 74(11), 6324–6330.
Vancouver
1.
Caljon G, Van Den Abbeele J, Stijlemans B, Coosemans M, De Baetselier P, Magez S. Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response. INFECTION AND IMMUNITY. 2006;74(11):6324–30.
MLA
Caljon, Guy et al. “Tsetse Fly Saliva Accelerates the Onset of Trypanosoma Brucei Infection in a Mouse Model Associated with a Reduced Host Inflammatory Response.” INFECTION AND IMMUNITY 74.11 (2006): 6324–6330. Print.
@article{8614918,
  abstract     = {Tsetse flies (Glossina sp.) are the vectors that transmit African trypanosomes, protozoan parasites that cause human sleeping sickness and veterinary infections in the African continent. These blood-feeding dipteran insects deposit saliva at the feeding site that enables the blood-feeding process. Here we demonstrate that tsetse fly saliva also accelerates the onset of a Trypanosoma brucei infection. This effect was associated with a reduced inflammatory reaction at the site of infection initiation (reflected by a decrease of interleukin-6 [IL-6] and IL-12 mRNA) as well as lower serum concentrations of the trypanocidal cytokine tumor necrosis factor. Variant-specific surface glycoprotein-specific antibody isotypes immunoglobulin M (IgM) and IgG2a, implicated in trypanosome clearance, were not suppressed. We propose that tsetse fly saliva accelerates the onset of trypanosome infection by inhibiting local and systemic inflammatory responses involved in parasite control.},
  author       = {Caljon, Guy and Van Den Abbeele, Jan and Stijlemans, Benoit and Coosemans, Marc and De Baetselier, Patrick and Magez, Stefan},
  issn         = {0019-9567},
  journal      = {INFECTION AND IMMUNITY},
  language     = {eng},
  number       = {11},
  pages        = {6324--6330},
  title        = {Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response},
  url          = {http://dx.doi.org/10.1128/iai.01046-06},
  volume       = {74},
  year         = {2006},
}

Altmetric
View in Altmetric