Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 2.90 MB
Add to list
  1. Search results
  2. Deletion of autism risk gene Shank3 d...

Deletion of autism risk gene Shank3 disrupts prefrontal connectivity

Marco Pagani, Alice Bertero, Adam Liska, Alberto Galbusera, Mara Sabbioni, Noemi Barsotti, Nigel Colenbier (UGent) , Daniele Marinazzo (UGent) , Maria Luisa Scattoni, Massimo Pasqualetti, et al.
(2019) JOURNAL OF NEUROSCIENCE. 39(27). p.5299-5310
Author
Organization
Abstract
Mutations in the synaptic scaffolding protein Shank3 are a major cause of autism, and are associated with prominent intellectual and language deficits. However, the neural mechanisms whereby SHANK3 deficiency affects higher order socio-communicative functions remain unclear. Using high-resolution functional and structural MRI in adult male mice, here we show that loss of Shank3 (Shank3B-/-) results in disrupted local and long-range prefrontal and fronto-striatal functional connectivity. We document that prefrontal hypo-connectivity is associated with reduced short-range cortical projections density, and reduced gray matter volume. Finally, we show that prefrontal disconnectivity is predictive of social communication deficits, as assessed with ultrasound vocalization recordings. Collectively, our results reveal a critical role of SHANK3 in the development of prefrontal anatomy and function, and suggest that SHANK3 deficiency may predispose to intellectual disability and socio-communicative impairments via dysregulation of higher-order cortical connectivity.
Keywords
autism, brain connectivity, fMRI, mouse, autism spectrum disorder, basal ganglia, functional connectivity, mouse, Phelan-McDermid syndrome, resting state fMRI, FUNCTIONAL CONNECTIVITY, MOUSE, NETWORKS, MICE, EXPRESSION, ANESTHESIA, CIRCUITS, PROTEINS, SYNAPSE, CORTEX

Downloads

  • Download
    5299.full.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 2.90 MB

Citation

Please use this url to cite or link to this publication:

MLA
Pagani, Marco, et al. “Deletion of Autism Risk Gene Shank3 Disrupts Prefrontal Connectivity.” JOURNAL OF NEUROSCIENCE, vol. 39, no. 27, 2019, pp. 5299–310, doi:10.1523/JNEUROSCI.2529-18.2019.
APA
Pagani, M., Bertero, A., Liska, A., Galbusera, A., Sabbioni, M., Barsotti, N., … Gozzi, A. (2019). Deletion of autism risk gene Shank3 disrupts prefrontal connectivity. JOURNAL OF NEUROSCIENCE, 39(27), 5299–5310. https://doi.org/10.1523/JNEUROSCI.2529-18.2019
Chicago author-date
Pagani, Marco, Alice Bertero, Adam Liska, Alberto Galbusera, Mara Sabbioni, Noemi Barsotti, Nigel Colenbier, et al. 2019. “Deletion of Autism Risk Gene Shank3 Disrupts Prefrontal Connectivity.” JOURNAL OF NEUROSCIENCE 39 (27): 5299–5310. https://doi.org/10.1523/JNEUROSCI.2529-18.2019.
Chicago author-date (all authors)
Pagani, Marco, Alice Bertero, Adam Liska, Alberto Galbusera, Mara Sabbioni, Noemi Barsotti, Nigel Colenbier, Daniele Marinazzo, Maria Luisa Scattoni, Massimo Pasqualetti, and Alessandro Gozzi. 2019. “Deletion of Autism Risk Gene Shank3 Disrupts Prefrontal Connectivity.” JOURNAL OF NEUROSCIENCE 39 (27): 5299–5310. doi:10.1523/JNEUROSCI.2529-18.2019.
Vancouver
1.
Pagani M, Bertero A, Liska A, Galbusera A, Sabbioni M, Barsotti N, et al. Deletion of autism risk gene Shank3 disrupts prefrontal connectivity. JOURNAL OF NEUROSCIENCE. 2019;39(27):5299–310.
IEEE
[1]
M. Pagani et al., “Deletion of autism risk gene Shank3 disrupts prefrontal connectivity,” JOURNAL OF NEUROSCIENCE, vol. 39, no. 27, pp. 5299–5310, 2019.
@article{8614750,
  abstract     = {{Mutations in the synaptic scaffolding protein Shank3 are a major cause of autism, and are associated with prominent intellectual and language deficits. However, the neural mechanisms whereby SHANK3 deficiency affects higher order socio-communicative functions remain unclear. Using high-resolution functional and structural MRI in adult male mice, here we show that loss of Shank3 (Shank3B-/-) results in disrupted local and long-range prefrontal and fronto-striatal functional connectivity. We document that prefrontal hypo-connectivity is associated with reduced short-range cortical projections density, and reduced gray matter volume. Finally, we show that prefrontal disconnectivity is predictive of social communication deficits, as assessed with ultrasound vocalization recordings. Collectively, our results reveal a critical role of SHANK3 in the development of prefrontal anatomy and function, and suggest that SHANK3 deficiency may predispose to intellectual disability and socio-communicative impairments via dysregulation of higher-order cortical connectivity.}},
  author       = {{Pagani, Marco and Bertero, Alice and Liska, Adam and Galbusera, Alberto and Sabbioni, Mara and Barsotti, Noemi and Colenbier, Nigel and Marinazzo, Daniele and Scattoni, Maria Luisa and Pasqualetti, Massimo and Gozzi, Alessandro}},
  issn         = {{0270-6474}},
  journal      = {{JOURNAL OF NEUROSCIENCE}},
  keywords     = {{autism,brain connectivity,fMRI,mouse,autism spectrum disorder,basal ganglia,functional connectivity,mouse,Phelan-McDermid syndrome,resting state fMRI,FUNCTIONAL CONNECTIVITY,MOUSE,NETWORKS,MICE,EXPRESSION,ANESTHESIA,CIRCUITS,PROTEINS,SYNAPSE,CORTEX}},
  language     = {{eng}},
  number       = {{27}},
  pages        = {{5299--5310}},
  title        = {{Deletion of autism risk gene Shank3 disrupts prefrontal connectivity}},
  url          = {{http://doi.org/10.1523/JNEUROSCI.2529-18.2019}},
  volume       = {{39}},
  year         = {{2019}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: