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Coinfection with Trypanosoma brucei confers protection against cutaneous leishmaniasis

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Abstract
Infection with certain bacteria, parasites, and viruses alters the host immune system to Leishmania major influencing disease outcome. Here, we determined the outcome of a chronic infection with Trypanosoma brucei brucei on cutaneous leishmaniasis (CL) caused by L. major. C57BL/6 mice infected with T. b. brucei were given a sub-curative treatment with diminazene aceturate then coinfected with L. major by vector bites. Our results revealed that infection with T. b. brucei controls CL pathology. Compared to controls, coinfected mice showed a significant decrease in lesion size (P < 0.05) up to 6 weeks post-infection and a significant decrease in parasite burden (P < 0.0001) at 3 weeks post-infection. Protection against L. major resulted from a non-specific activation of T cells by trypanosomes. This induced a strong immune response characterized by IFN-gamma production at the site of bites and systemically, creating a hostile inflammatory environment for L. major parasites and conferring protection from CL.
Keywords
Leishmania major, Trypanosoma brucei, coinfection, inflammation, cellular immunity, humoral immunity, cutaneous leishmaniasis, protection, HIV COINFECTION, AFRICAN TRYPANOSOMIASIS, VISCERAL LEISHMANIASIS, CONSEQUENCES, PARASITE, VIRUS, BITES, CELLS

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MLA
Pereira, Lais et al. “Coinfection with Trypanosoma Brucei Confers Protection Against Cutaneous Leishmaniasis.” FRONTIERS IN IMMUNOLOGY 9 (2018): n. pag. Print.
APA
Pereira, L., Oliveira, F., Townsend, S., Metangmo, S., Meneses, C., Moore, I. N., Brodskyn, C. I., et al. (2018). Coinfection with Trypanosoma brucei confers protection against cutaneous leishmaniasis. FRONTIERS IN IMMUNOLOGY, 9.
Chicago author-date
Pereira, Lais, Fabiano Oliveira, Shannon Townsend, Sonia Metangmo, Claudio Meneses, Ian N Moore, Claudia I Brodskyn, Jesus G Valenzuela, Stefan Magez, and Shaden Kamhawi. 2018. “Coinfection with Trypanosoma Brucei Confers Protection Against Cutaneous Leishmaniasis.” Frontiers in Immunology 9.
Chicago author-date (all authors)
Pereira, Lais, Fabiano Oliveira, Shannon Townsend, Sonia Metangmo, Claudio Meneses, Ian N Moore, Claudia I Brodskyn, Jesus G Valenzuela, Stefan Magez, and Shaden Kamhawi. 2018. “Coinfection with Trypanosoma Brucei Confers Protection Against Cutaneous Leishmaniasis.” Frontiers in Immunology 9.
Vancouver
1.
Pereira L, Oliveira F, Townsend S, Metangmo S, Meneses C, Moore IN, et al. Coinfection with Trypanosoma brucei confers protection against cutaneous leishmaniasis. FRONTIERS IN IMMUNOLOGY. 2018;9.
IEEE
[1]
L. Pereira et al., “Coinfection with Trypanosoma brucei confers protection against cutaneous leishmaniasis,” FRONTIERS IN IMMUNOLOGY, vol. 9, 2018.
@article{8614589,
  abstract     = {Infection with certain bacteria, parasites, and viruses alters the host immune system to Leishmania major influencing disease outcome. Here, we determined the outcome of a chronic infection with Trypanosoma brucei brucei on cutaneous leishmaniasis (CL) caused by L. major. C57BL/6 mice infected with T. b. brucei were given a sub-curative treatment with diminazene aceturate then coinfected with L. major by vector bites. Our results revealed that infection with T. b. brucei controls CL pathology. Compared to controls, coinfected mice showed a significant decrease in lesion size (P < 0.05) up to 6 weeks post-infection and a significant decrease in parasite burden (P < 0.0001) at 3 weeks post-infection. Protection against L. major resulted from a non-specific activation of T cells by trypanosomes. This induced a strong immune response characterized by IFN-gamma production at the site of bites and systemically, creating a hostile inflammatory environment for L. major parasites and conferring protection from CL.},
  articleno    = {2855},
  author       = {Pereira, Lais and Oliveira, Fabiano and Townsend, Shannon and Metangmo, Sonia and Meneses, Claudio and Moore, Ian N and Brodskyn, Claudia I and Valenzuela, Jesus G and Magez, Stefan and Kamhawi, Shaden},
  issn         = {1664-3224},
  journal      = {FRONTIERS IN IMMUNOLOGY},
  keywords     = {Leishmania major,Trypanosoma brucei,coinfection,inflammation,cellular immunity,humoral immunity,cutaneous leishmaniasis,protection,HIV COINFECTION,AFRICAN TRYPANOSOMIASIS,VISCERAL LEISHMANIASIS,CONSEQUENCES,PARASITE,VIRUS,BITES,CELLS},
  language     = {eng},
  pages        = {9},
  title        = {Coinfection with Trypanosoma brucei confers protection against cutaneous leishmaniasis},
  url          = {http://dx.doi.org/10.3389/fimmu.2018.02855},
  volume       = {9},
  year         = {2018},
}

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