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Photo-crosslinkable recombinant collagen mimics for tissue engineering applications

(2019) JOURNAL OF MATERIALS CHEMISTRY B. 7(19). p.3100-3108
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Abstract
Gelatin is frequently used in various biomedical applications. However, gelatin is generally extracted from an animal source, which can result in issues with reproducibility as well as pathogen transmittance. Therefore, we have investigated the potential of a recombinant peptide based on collagen I (RCPhC1) for tissue engineering applications and more specifically for adipose tissue regeneration. In the current paper, RCPhC1 was functionalized with photo-crosslinkable methacrylamide moieties to enable subsequent UV-induced crosslinking in the presence of a photo-initiator. The resulting biomaterial (RCPhC1-MA) was characterized by evaluating the crosslinking behaviour, the mechanical properties, the gel fraction, the swelling properties and the biocompatibility. The obtained results were compared with the data obtained for methacrylamide-modified gelatin (Gel-MA). The results indicated that the properties of RCPhC1-MA networks are comparable to those of animal-derived Gel-MA. RCPhC1-MA is thus an attractive synthetic alternative for animal-derived Gel-MA and is envisioned to be applicable for a wide range of tissue engineering purposes.
Keywords
IN-VITRO, MECHANICAL-PROPERTIES, GELATIN METHACRYLOYL, HYDROGELS. PART, BEHAVIOR

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MLA
Tytgat, Liesbeth, et al. “Photo-Crosslinkable Recombinant Collagen Mimics for Tissue Engineering Applications.” JOURNAL OF MATERIALS CHEMISTRY B, vol. 7, no. 19, 2019, pp. 3100–08.
APA
Tytgat, L., Markovic, M., Qazi, T. H., Vagenende, M., Bray, F., Martins, J., … Van Vlierberghe, S. (2019). Photo-crosslinkable recombinant collagen mimics for tissue engineering applications. JOURNAL OF MATERIALS CHEMISTRY B, 7(19), 3100–3108.
Chicago author-date
Tytgat, Liesbeth, Marica Markovic, Taimoor H Qazi, Maxime Vagenende, Fabrice Bray, José Martins, Christian Rolando, et al. 2019. “Photo-Crosslinkable Recombinant Collagen Mimics for Tissue Engineering Applications.” JOURNAL OF MATERIALS CHEMISTRY B 7 (19): 3100–3108.
Chicago author-date (all authors)
Tytgat, Liesbeth, Marica Markovic, Taimoor H Qazi, Maxime Vagenende, Fabrice Bray, José Martins, Christian Rolando, Hugo Thienpont, Heidi Ottevaere, Aleksandr Ovsianikov, Peter Dubruel, and Sandra Van Vlierberghe. 2019. “Photo-Crosslinkable Recombinant Collagen Mimics for Tissue Engineering Applications.” JOURNAL OF MATERIALS CHEMISTRY B 7 (19): 3100–3108.
Vancouver
1.
Tytgat L, Markovic M, Qazi TH, Vagenende M, Bray F, Martins J, et al. Photo-crosslinkable recombinant collagen mimics for tissue engineering applications. JOURNAL OF MATERIALS CHEMISTRY B. 2019;7(19):3100–8.
IEEE
[1]
L. Tytgat et al., “Photo-crosslinkable recombinant collagen mimics for tissue engineering applications,” JOURNAL OF MATERIALS CHEMISTRY B, vol. 7, no. 19, pp. 3100–3108, 2019.
@article{8614460,
  abstract     = {{Gelatin is frequently used in various biomedical applications. However, gelatin is generally extracted from an animal source, which can result in issues with reproducibility as well as pathogen transmittance. Therefore, we have investigated the potential of a recombinant peptide based on collagen I (RCPhC1) for tissue engineering applications and more specifically for adipose tissue regeneration. In the current paper, RCPhC1 was functionalized with photo-crosslinkable methacrylamide moieties to enable subsequent UV-induced crosslinking in the presence of a photo-initiator. The resulting biomaterial (RCPhC1-MA) was characterized by evaluating the crosslinking behaviour, the mechanical properties, the gel fraction, the swelling properties and the biocompatibility. The obtained results were compared with the data obtained for methacrylamide-modified gelatin (Gel-MA). The results indicated that the properties of RCPhC1-MA networks are comparable to those of animal-derived Gel-MA. RCPhC1-MA is thus an attractive synthetic alternative for animal-derived Gel-MA and is envisioned to be applicable for a wide range of tissue engineering purposes.}},
  author       = {{Tytgat, Liesbeth and Markovic, Marica and Qazi, Taimoor H and Vagenende, Maxime and Bray, Fabrice and Martins, José and Rolando, Christian and Thienpont, Hugo and Ottevaere, Heidi and Ovsianikov, Aleksandr and Dubruel, Peter and Van Vlierberghe, Sandra}},
  issn         = {{2050-750X}},
  journal      = {{JOURNAL OF MATERIALS CHEMISTRY B}},
  keywords     = {{IN-VITRO,MECHANICAL-PROPERTIES,GELATIN METHACRYLOYL,HYDROGELS. PART,BEHAVIOR}},
  language     = {{eng}},
  number       = {{19}},
  pages        = {{3100--3108}},
  title        = {{Photo-crosslinkable recombinant collagen mimics for tissue engineering applications}},
  url          = {{http://dx.doi.org/10.1039/C8TB03308K}},
  volume       = {{7}},
  year         = {{2019}},
}

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