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The cytokines of asthma

Bart Lambrecht (UGent) , Hamida Hammad (UGent) and John V. Fahy
(2019) IMMUNITY. 50(4). p.975-991
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Abstract
Asthma is a chronic inflammatory airway disease associated with type 2 cytokincs interleukin-4 (IL-4), IL. and IL-13, whicn promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response. "Type 2-low" asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation. Here, we review the cytokine networks driving asthma, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic. We discuss established and emerging paradigms in the context of the growing appreciation of disease heterogeneity and argue that the development of new and improved therapeutics require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.
Keywords
INNATE LYMPHOID-CELLS, THYMIC STROMAL LYMPHOPOIETIN, HOUSE-DUST MITE, ALLERGIC AIRWAY INFLAMMATION, NATURAL HELPER-CELLS, NECROSIS-FACTOR-ALPHA, T-CELLS, DENDRITIC CELLS, DOUBLE-BLIND, TYPE-2, INFLAMMATION

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Citation

Please use this url to cite or link to this publication:

Chicago
Lambrecht, Bart, Hamida Hammad, and John V. Fahy. 2019. “The Cytokines of Asthma.” Immunity 50 (4): 975–991.
APA
Lambrecht, B., Hammad, H., & Fahy, J. V. (2019). The cytokines of asthma. IMMUNITY, 50(4), 975–991.
Vancouver
1.
Lambrecht B, Hammad H, Fahy JV. The cytokines of asthma. IMMUNITY. 2019;50(4):975–91.
MLA
Lambrecht, Bart, Hamida Hammad, and John V. Fahy. “The Cytokines of Asthma.” IMMUNITY 50.4 (2019): 975–991. Print.
@article{8614357,
  abstract     = {Asthma is a chronic inflammatory airway disease associated with type 2 cytokincs interleukin-4 (IL-4), IL. and IL-13, whicn promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerbated Type 2 response. "Type 2-low" asthma has different immune features: airway neutrophilia, obesity-related systemic inflammation, or in some cases, few signs of immune activation. Here, we review the cytokine networks driving asthma, placing these in cellular context and incorporating insights from cytokine-targeting therapies in the clinic. We discuss established and emerging paradigms in the context of the growing appreciation of disease heterogeneity and argue that the development of new and improved therapeutics require understanding the diverse mechanisms underlying the spectrum of asthma pathologies.},
  author       = {Lambrecht, Bart and Hammad, Hamida and Fahy, John V.},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keywords     = {INNATE LYMPHOID-CELLS,THYMIC STROMAL LYMPHOPOIETIN,HOUSE-DUST MITE,ALLERGIC AIRWAY INFLAMMATION,NATURAL HELPER-CELLS,NECROSIS-FACTOR-ALPHA,T-CELLS,DENDRITIC CELLS,DOUBLE-BLIND,TYPE-2,INFLAMMATION},
  language     = {eng},
  number       = {4},
  pages        = {975--991},
  title        = {The cytokines of asthma},
  url          = {http://dx.doi.org/10.1016/j.immuni.2019.03.018},
  volume       = {50},
  year         = {2019},
}

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