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Relationship between Exercise-Induced Oxidative Stress Changes and Parasympathetic Activity in patients with Chronic Fatigue Syndrome and Healthy Subjects: an Observational Study

(2019) Clinical Therapeutics. 41(4). p.641-655
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Abstract
PURPOSE:Oxidative stress has been proposed as a contributor to pain in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). During incremental exercise in patients with ME/CFS, oxidative stress enhances sooner and antioxidant response is delayed. We explored whether oxidative stress is associated with pain symptoms or pain changes following exercise, and the possible relationships between oxidative stress and parasympathetic vagal nerve activity in patients with ME/CFS versus healthy, inactive controls. METHODS:The present study reports secondary outcomes from a previous work. Data from 36 participants were studied (women with ME/CFS and healthy controls). Subjects performed a submaximal exercise test with continuous cardiorespiratory monitoring. Levels of thiobarbituric acid-reactive substances (TBARSs) were used as a measure of oxidative stress, and heart rate variability was used to assess vagal activity. Before and after the exercise, subjects were asked to rate their pain using a visual analogic scale. FINDINGS:Significant between-group differences in pain at both baseline and following exercise were found (both, P < 0.007). In healthy controls, pain was significantly improved following exercise (P = 0.002). No change in oxidative stress level after exercise was found. Significant correlation between TBARS levels and pain was found at baseline (r = 0.540; P = 0.021) and after exercise (r = 0.524; P = 0.024) in patients only. No significant correlation between TBARS and heart rate variability at baseline or following exercise was found in either group. However, a significant correlation was found between exercise-induced changes in HRV and TBARS in healthy controls (r = -0.720; P = 0.001). IMPLICATIONS:Oxidative stress showed an association with pain symptoms in people with ME/CFS, but no exercise-induced changes in oxidative stress were found. In addition, the change in parasympathetic activity following exercise partially accounted for the change in oxidative stress in healthy controls. More research is required to further explore this link.
Keywords
Autonomic nervous system, Chronic fatigue syndrome, Exercise, Oxidative stress, Pain

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Citation

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Chicago
Van Oosterwijck, Jessica, Andrea Polli, Jo Nijs, Uros Marusic, Inge De Wandele, Lora Paul, Mira Meeus, Greta Moorkens, Luc Lambrecht, and Kally Ickmans. 2019. “Relationship Between Exercise-Induced Oxidative Stress Changes and Parasympathetic Activity in Patients with Chronic Fatigue Syndrome and Healthy Subjects: An Observational Study.” Clinical Therapeutics 41 (4): 641–655.
APA
Van Oosterwijck, J., Polli, A., Nijs, J., Marusic, U., De Wandele, I., Paul, L., Meeus, M., et al. (2019). Relationship between Exercise-Induced Oxidative Stress Changes and Parasympathetic Activity in patients with Chronic Fatigue Syndrome and Healthy Subjects: an Observational Study. Clinical Therapeutics, 41(4), 641–655.
Vancouver
1.
Van Oosterwijck J, Polli A, Nijs J, Marusic U, De Wandele I, Paul L, et al. Relationship between Exercise-Induced Oxidative Stress Changes and Parasympathetic Activity in patients with Chronic Fatigue Syndrome and Healthy Subjects: an Observational Study. Clinical Therapeutics. 2019;41(4):641–55.
MLA
Van Oosterwijck, Jessica et al. “Relationship Between Exercise-Induced Oxidative Stress Changes and Parasympathetic Activity in Patients with Chronic Fatigue Syndrome and Healthy Subjects: An Observational Study.” Clinical Therapeutics 41.4 (2019): 641–655. Print.
@article{8614235,
  abstract     = {PURPOSE:Oxidative stress has been proposed as a contributor to pain in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). During incremental exercise in patients with ME/CFS, oxidative stress enhances sooner and antioxidant response is delayed. We explored whether oxidative stress is associated with pain symptoms or pain changes following exercise, and the possible relationships between oxidative stress and parasympathetic vagal nerve activity in patients with ME/CFS versus healthy, inactive controls.
METHODS:The present study reports secondary outcomes from a previous work. Data from 36 participants were studied (women with ME/CFS and healthy controls). Subjects performed a submaximal exercise test with continuous cardiorespiratory monitoring. Levels of thiobarbituric acid-reactive substances (TBARSs) were used as a measure of oxidative stress, and heart rate variability was used to assess vagal activity. Before and after the exercise, subjects were asked to rate their pain using a visual analogic scale.
FINDINGS:Significant between-group differences in pain at both baseline and following exercise were found (both, P < 0.007). In healthy controls, pain was significantly improved following exercise (P = 0.002). No change in oxidative stress level after exercise was found. Significant correlation between TBARS levels and pain was found at baseline (r = 0.540; P = 0.021) and after exercise (r = 0.524; P = 0.024) in patients only. No significant correlation between TBARS and heart rate variability at baseline or following exercise was found in either group. However, a significant correlation was found between exercise-induced changes in HRV and TBARS in healthy controls (r = -0.720; P = 0.001).
IMPLICATIONS:Oxidative stress showed an association with pain symptoms in people with ME/CFS, but no exercise-induced changes in oxidative stress were found. In addition, the change in parasympathetic activity following exercise partially accounted for the change in oxidative stress in healthy controls. More research is required to further explore this link.
},
  author       = {Van Oosterwijck, Jessica and Polli, Andrea and Nijs, Jo and Marusic, Uros and De Wandele, Inge and Paul, Lora and Meeus, Mira and Moorkens, Greta and Lambrecht, Luc and Ickmans, Kally},
  journal      = {Clinical Therapeutics},
  keywords     = {Autonomic nervous system,Chronic fatigue syndrome,Exercise,Oxidative stress,Pain},
  language     = {eng},
  number       = {4},
  pages        = {641--655},
  title        = {Relationship between Exercise-Induced Oxidative Stress Changes and Parasympathetic Activity in patients with Chronic Fatigue Syndrome and Healthy Subjects: an Observational Study},
  url          = {http://dx.doi.org/10.1016/j.clinthera.2018.12.012},
  volume       = {41},
  year         = {2019},
}

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