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Intersections between regulated cell death and autophagy

(2019) TRENDS IN CELL BIOLOGY. 29(4). p.323-338
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Abstract
In multicellular organisms, cell death is an essential aspect of life. Over the past decade, the spectrum of different forms of regulated cell death (RCD) has expanded dramatically with relevance in several pathologies such as inflammatory and neurodegenerative diseases. This has been paralleled by the growing awareness of the central importance of autophagy as a stress response that influences decisions of cell life and cell death. Here, we first introduce criteria and methodologies for correct identification of the different RCD forms. We then discuss how the autophagy machinery is directly associated with specific cell death forms and dissect the complex interactions between autophagy and apoptotic and necrotic cell death. This highlights how the balance of the relationship between other cell death pathways and autophagy presides over life and death in specific cellular contexts.
Keywords
MITOCHONDRIAL PERMEABILITY TRANSITION, LYSOSOMAL MEMBRANE, PERMEABILIZATION, MEDIATED CLEAVAGE, NONAPOPTOTIC NEURODEGENERATION, INTRANUCLEAR INCLUSIONS, POLYGLUTAMINE ATROPHIN, TRANSGENIC MICE, NECROTIC CELLS, GROWTH ARREST, MOUSE MODEL

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Citation

Please use this url to cite or link to this publication:

MLA
Napoletano, Francesco et al. “Intersections Between Regulated Cell Death and Autophagy.” TRENDS IN CELL BIOLOGY 29.4 (2019): 323–338. Print.
APA
Napoletano, F., Baron, O., Vandenabeele, P., Mollereau, B., & Fanto, M. (2019). Intersections between regulated cell death and autophagy. TRENDS IN CELL BIOLOGY, 29(4), 323–338.
Chicago author-date
Napoletano, Francesco, Olga Baron, Peter Vandenabeele, Bertrand Mollereau, and Manolis Fanto. 2019. “Intersections Between Regulated Cell Death and Autophagy.” Trends in Cell Biology 29 (4): 323–338.
Chicago author-date (all authors)
Napoletano, Francesco, Olga Baron, Peter Vandenabeele, Bertrand Mollereau, and Manolis Fanto. 2019. “Intersections Between Regulated Cell Death and Autophagy.” Trends in Cell Biology 29 (4): 323–338.
Vancouver
1.
Napoletano F, Baron O, Vandenabeele P, Mollereau B, Fanto M. Intersections between regulated cell death and autophagy. TRENDS IN CELL BIOLOGY. 2019;29(4):323–38.
IEEE
[1]
F. Napoletano, O. Baron, P. Vandenabeele, B. Mollereau, and M. Fanto, “Intersections between regulated cell death and autophagy,” TRENDS IN CELL BIOLOGY, vol. 29, no. 4, pp. 323–338, 2019.
@article{8613533,
  abstract     = {In multicellular organisms, cell death is an essential aspect of life. Over the past decade, the spectrum of different forms of regulated cell death (RCD) has expanded dramatically with relevance in several pathologies such as inflammatory and neurodegenerative diseases. This has been paralleled by the growing awareness of the central importance of autophagy as a stress response that influences decisions of cell life and cell death. Here, we first introduce criteria and methodologies for correct identification of the different RCD forms. We then discuss how the autophagy machinery is directly associated with specific cell death forms and dissect the complex interactions between autophagy and apoptotic and necrotic cell death. This highlights how the balance of the relationship between other cell death pathways and autophagy presides over life and death in specific cellular contexts.},
  author       = {Napoletano, Francesco and Baron, Olga and Vandenabeele, Peter and Mollereau, Bertrand and Fanto, Manolis},
  issn         = {0962-8924},
  journal      = {TRENDS IN CELL BIOLOGY},
  keywords     = {MITOCHONDRIAL PERMEABILITY TRANSITION,LYSOSOMAL MEMBRANE,PERMEABILIZATION,MEDIATED CLEAVAGE,NONAPOPTOTIC NEURODEGENERATION,INTRANUCLEAR INCLUSIONS,POLYGLUTAMINE ATROPHIN,TRANSGENIC MICE,NECROTIC CELLS,GROWTH ARREST,MOUSE MODEL},
  language     = {eng},
  number       = {4},
  pages        = {323--338},
  title        = {Intersections between regulated cell death and autophagy},
  url          = {http://dx.doi.org/10.1016/j.tcb.2018.12.007},
  volume       = {29},
  year         = {2019},
}

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