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Supervisory process monitoring, identification and control for continuous pharmaceutical wet granulation

Niels Nicolaï (UGent)
(2019)
Author
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(UGent) , (UGent) and Krist V Gernaey
Organization
Abstract
The pharmaceutical industry is facing some major challenges in the 21st century. Most notably are the decrease in research and development productivity and the ever increasing competition because of patent expiration. This triggered the industry and its regulators to rethink the entire business. One particular measure is the aim for faster drug development using flexible manufacturing technologies based on fundamental scientific process understanding. Hence, the aim of this doctoral thesis is to investigate the opportunities of automatic process control in the continuous manufacturing of pharmaceutical tablets. It is illustrated how a combination of real-time chemical and physical product analyzers can be combined with mathematical models to monitor and predict the state of intermediate products in real-time. Moreover, these novel tools were applied in automated control strategies in order to ensure the required drug product quality at all times.
Keywords
twin-screw granulation, advanced process control, process analytical technology, system identification

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Citation

Please use this url to cite or link to this publication:

Chicago
Nicolaï, Niels. 2019. “Supervisory Process Monitoring, Identification and Control for Continuous Pharmaceutical Wet Granulation”. Ghent, Belgium: Ghent University. Faculty of Bioscience Engineering.
APA
Nicolaï, N. (2019). Supervisory process monitoring, identification and control for continuous pharmaceutical wet granulation. Ghent University. Faculty of Bioscience Engineering, Ghent, Belgium.
Vancouver
1.
Nicolaï N. Supervisory process monitoring, identification and control for continuous pharmaceutical wet granulation. [Ghent, Belgium]: Ghent University. Faculty of Bioscience Engineering; 2019.
MLA
Nicolaï, Niels. “Supervisory Process Monitoring, Identification and Control for Continuous Pharmaceutical Wet Granulation.” 2019 : n. pag. Print.
@phdthesis{8612958,
  abstract     = {The pharmaceutical industry is facing some major challenges in the 21st century. Most notably are the decrease in research and development productivity and the ever increasing competition because of patent expiration. This triggered the industry and its regulators to rethink the entire business. One particular measure is the aim for faster drug development using flexible manufacturing technologies based on fundamental scientific process understanding. Hence, the aim of this doctoral thesis is to investigate the opportunities of automatic process control in the continuous manufacturing of pharmaceutical tablets. It is illustrated how a combination of real-time chemical and physical product analyzers can be combined with mathematical models to monitor and predict the state of intermediate products in real-time. Moreover, these novel tools were applied in automated control strategies in order to ensure the required drug product quality at all times.},
  author       = {Nicolaï, Niels},
  isbn         = {9789463571999},
  keywords     = {twin-screw granulation,advanced process control,process analytical technology,system identification},
  language     = {eng},
  pages        = {XXX, 299},
  publisher    = {Ghent University. Faculty of Bioscience Engineering},
  school       = {Ghent University},
  title        = {Supervisory process monitoring, identification and control for continuous pharmaceutical wet granulation},
  year         = {2019},
}