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Validation of a physician global assessment tool for vitiligo extent : results of an international vitiligo expert meeting

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Abstract
Currently, vitiligo lacks a validated Physician Global Assessment (PGA) for disease extent. This PGA can be used to stratify and interpret the numeric scores obtained by the Vitiligo Extent Score (VES). We investigated the interrater reliability of a 5-point PGA scale during an international vitiligo workshop. Vitiligo experts from five different continents rated photographs of non-segmental vitiligo patients with varying degrees of extent with the PGA score. Good interrater agreements (intraclass correlation coefficient >0.6) were observed between the raters overall and within each continent. All hypotheses to evaluate construct validity were confirmed. Median VES values per category were for limited 1.10 [IQR: 0.21-1.67], moderate 3.17 [IQR: 1.75-6.21], extensive 9.58 [IQR: 6.21-13.03] and very extensive 42.67 [IQR: 21.20-42.67]. Defined categories for vitiligo extent can be valuable for inclusion criteria and may impact future reimbursement criteria.
Keywords
body surface area, extent, global assessment, outcome measure, severity, vitiligo, OUTCOME MEASUREMENTS, SEVERITY INDEX, ECZEMA, PSORIASIS, QUALITY, COSMIN, AREA

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MLA
van Geel, Nanja, et al. “Validation of a Physician Global Assessment Tool for Vitiligo Extent : Results of an International Vitiligo Expert Meeting.” PIGMENT CELL & MELANOMA RESEARCH, vol. 32, no. 5, 2019, pp. 728–33.
APA
van Geel, N., Wolkerstorfer, A., Ezzedine, K., Pandya, A. G., Bekkenk, M., Grine, L., … Speeckaert, R. (2019). Validation of a physician global assessment tool for vitiligo extent : results of an international vitiligo expert meeting. PIGMENT CELL & MELANOMA RESEARCH, 32(5), 728–733.
Chicago author-date
Geel, Nanja van, Albert Wolkerstorfer, Khaled Ezzedine, Amit G Pandya, Marcel Bekkenk, Lynda Grine, Sarah Van Belle, et al. 2019. “Validation of a Physician Global Assessment Tool for Vitiligo Extent : Results of an International Vitiligo Expert Meeting.” PIGMENT CELL & MELANOMA RESEARCH 32 (5): 728–33.
Chicago author-date (all authors)
van Geel, Nanja, Albert Wolkerstorfer, Khaled Ezzedine, Amit G Pandya, Marcel Bekkenk, Lynda Grine, Sarah Van Belle, Janny E Lommerts, Iltefat Hamzavi, John E Harris, Viktoria Eleftheriadou, Samia Esmat, Hee Young Kang, Prasad Kumarasinghe, Cheng‐Che E Lan, Davinder Parsad, Noufal Raboobee, Leihong Flora Xiang, Tamio Suzuki, Cecilia A Prinsen, Alain Taieb, Mauro Picardo, and Reinhart Speeckaert. 2019. “Validation of a Physician Global Assessment Tool for Vitiligo Extent : Results of an International Vitiligo Expert Meeting.” PIGMENT CELL & MELANOMA RESEARCH 32 (5): 728–733.
Vancouver
1.
van Geel N, Wolkerstorfer A, Ezzedine K, Pandya AG, Bekkenk M, Grine L, et al. Validation of a physician global assessment tool for vitiligo extent : results of an international vitiligo expert meeting. PIGMENT CELL & MELANOMA RESEARCH. 2019;32(5):728–33.
IEEE
[1]
N. van Geel et al., “Validation of a physician global assessment tool for vitiligo extent : results of an international vitiligo expert meeting,” PIGMENT CELL & MELANOMA RESEARCH, vol. 32, no. 5, pp. 728–733, 2019.
@article{8612832,
  abstract     = {Currently, vitiligo lacks a validated Physician Global Assessment (PGA) for disease extent. This PGA can be used to stratify and interpret the numeric scores obtained by the Vitiligo Extent Score (VES). We investigated the interrater reliability of a 5-point PGA scale during an international vitiligo workshop. Vitiligo experts from five different continents rated photographs of non-segmental vitiligo patients with varying degrees of extent with the PGA score. Good interrater agreements (intraclass correlation coefficient >0.6) were observed between the raters overall and within each continent. All hypotheses to evaluate construct validity were confirmed. Median VES values per category were for limited 1.10 [IQR: 0.21-1.67], moderate 3.17 [IQR: 1.75-6.21], extensive 9.58 [IQR: 6.21-13.03] and very extensive 42.67 [IQR: 21.20-42.67]. Defined categories for vitiligo extent can be valuable for inclusion criteria and may impact future reimbursement criteria.},
  author       = {van Geel, Nanja and Wolkerstorfer, Albert and Ezzedine, Khaled and Pandya, Amit G and Bekkenk, Marcel and Grine, Lynda and Van Belle, Sarah and Lommerts, Janny E and Hamzavi, Iltefat and Harris, John E and Eleftheriadou, Viktoria and Esmat, Samia and Kang, Hee Young and Kumarasinghe, Prasad and Lan, Cheng‐Che E and Parsad, Davinder and Raboobee, Noufal and Xiang, Leihong Flora and Suzuki, Tamio and Prinsen, Cecilia A and Taieb, Alain and Picardo, Mauro and Speeckaert, Reinhart},
  issn         = {1755-1471},
  journal      = {PIGMENT CELL & MELANOMA RESEARCH},
  keywords     = {body surface area,extent,global assessment,outcome measure,severity,vitiligo,OUTCOME MEASUREMENTS,SEVERITY INDEX,ECZEMA,PSORIASIS,QUALITY,COSMIN,AREA},
  language     = {eng},
  location     = {Detroit, MI, USA},
  number       = {5},
  pages        = {728--733},
  title        = {Validation of a physician global assessment tool for vitiligo extent : results of an international vitiligo expert meeting},
  url          = {http://dx.doi.org/10.1111/pcmr.12784},
  volume       = {32},
  year         = {2019},
}

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