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Growing blood vessels in space : preparation studies of the SPHEROIDS project using related ground-based studies

(2019) ACTA ASTRONAUTICA. 159. p.267-272
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Abstract
Endothelial cells (ECs) grow as single layers on the bottom surface of cell culture flasks under normal (1g) culture conditions. In numerous experiments using simulated microgravity we noticed that the ECs formed three-dimensional, tube-like cell aggregates resembling the intima of small, rudimentary blood vessels. The SPHEROIDS project has now shown that similar processes occur in space. For the first time, we were able to observe scaffold-free growth of human ECs into multicellular spheroids and tubular structures during an experiment in real microgravity. With further investigation of the space samples we hope to understand endothelial 3D growth and to improve the in vitro engineering of biocompatible vessels which could be used in surgery.
Keywords
Microgravity, Spaceflight, Random positioning machine, 3D growth, Spheroids, Tubular structures, HUMAN ENDOTHELIAL-CELLS, FIBROBLAST-GROWTH-FACTOR, THYROID-CANCER CELLS, SIMULATED MICROGRAVITY, 3-DIMENSIONAL GROWTH, GRAVITY, ANGIOGENESIS, CYTOSKELETON, INDUCTION, EXPOSURE

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Citation

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MLA
Krüger, Marcus et al. “Growing Blood Vessels in Space : Preparation Studies of the SPHEROIDS Project Using Related Ground-based Studies.” ACTA ASTRONAUTICA 159 (2019): 267–272. Print.
APA
Krüger, M., Kopp, S., Wehland, M., Bauer, J., Baatout, S., Moreels, M., Egli, M., et al. (2019). Growing blood vessels in space : preparation studies of the SPHEROIDS project using related ground-based studies. ACTA ASTRONAUTICA, 159, 267–272.
Chicago author-date
Krüger, Marcus, Sascha Kopp, Markus Wehland, Johann Bauer, Sarah Baatout, Marjan Moreels, Marcel Egli, Thomas J Corydon, Manfred Infanger, and Daniela Grimm. 2019. “Growing Blood Vessels in Space : Preparation Studies of the SPHEROIDS Project Using Related Ground-based Studies.” Acta Astronautica 159: 267–272.
Chicago author-date (all authors)
Krüger, Marcus, Sascha Kopp, Markus Wehland, Johann Bauer, Sarah Baatout, Marjan Moreels, Marcel Egli, Thomas J Corydon, Manfred Infanger, and Daniela Grimm. 2019. “Growing Blood Vessels in Space : Preparation Studies of the SPHEROIDS Project Using Related Ground-based Studies.” Acta Astronautica 159: 267–272.
Vancouver
1.
Krüger M, Kopp S, Wehland M, Bauer J, Baatout S, Moreels M, et al. Growing blood vessels in space : preparation studies of the SPHEROIDS project using related ground-based studies. ACTA ASTRONAUTICA. 2019;159:267–72.
IEEE
[1]
M. Krüger et al., “Growing blood vessels in space : preparation studies of the SPHEROIDS project using related ground-based studies,” ACTA ASTRONAUTICA, vol. 159, pp. 267–272, 2019.
@article{8612678,
  abstract     = {Endothelial cells (ECs) grow as single layers on the bottom surface of cell culture flasks under normal (1g) culture conditions. In numerous experiments using simulated microgravity we noticed that the ECs formed three-dimensional, tube-like cell aggregates resembling the intima of small, rudimentary blood vessels. The SPHEROIDS project has now shown that similar processes occur in space. For the first time, we were able to observe scaffold-free growth of human ECs into multicellular spheroids and tubular structures during an experiment in real microgravity. With further investigation of the space samples we hope to understand endothelial 3D growth and to improve the in vitro engineering of biocompatible vessels which could be used in surgery.},
  author       = {Krüger, Marcus and Kopp, Sascha and Wehland, Markus and Bauer, Johann and Baatout, Sarah and Moreels, Marjan and Egli, Marcel and Corydon, Thomas J and Infanger, Manfred and Grimm, Daniela},
  issn         = {0094-5765 },
  journal      = {ACTA ASTRONAUTICA},
  keywords     = {Microgravity,Spaceflight,Random positioning machine,3D growth,Spheroids,Tubular structures,HUMAN ENDOTHELIAL-CELLS,FIBROBLAST-GROWTH-FACTOR,THYROID-CANCER CELLS,SIMULATED MICROGRAVITY,3-DIMENSIONAL GROWTH,GRAVITY,ANGIOGENESIS,CYTOSKELETON,INDUCTION,EXPOSURE},
  language     = {eng},
  pages        = {267--272},
  title        = {Growing blood vessels in space : preparation studies of the SPHEROIDS project using related ground-based studies},
  url          = {http://dx.doi.org/10.1016/j.actaastro.2019.03.074},
  volume       = {159},
  year         = {2019},
}

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