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Synthesis of levulinic acid based poly(amine-co-ester)s

(2019) GREEN CHEMISTRY. 21(1). p.123-128
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Abstract
Four novel biobased monomers (i.e. two diesters and two hydroxyesters) bearing a tertiary amine in their backbone have been synthesized from the sustainable methyl levulinate and amino-alcohols/amino-esters derived from natural amino acids. Their homopolymerization/copolymerization with diols leads to six poly(amine-co-ester)s with various microstructures. These families of biodegradable polyesters have been reported to be efficient carriers for gene delivery. The polymers are carefully characterized by nuclear magnetic resonance spectroscopy (H-1 and C-13 NMR) and size exclusion chromatography (SEC), and exhibit molecular weights (M-n) up to 36 kg mol(-1) and dispersities (D) between 1.5 and 2.1. They also present good solubility in aqueous acidic media due to amine protonation. Such properties are promising for applications in the biomedical field or in personal care products.
Keywords
RING-OPENING POLYMERIZATION, GENE DELIVERY-SYSTEM, ALIPHATIC POLYESTERS, PARALLEL SYNTHESIS, NONVIRAL VECTORS, LIBRARY, COPOLYMER, CHEMICALS, MICELLES, PLATFORM

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Chicago
Bernhard, Yann, Lucas Pagies, Sylvain Pellegrini, Till Bousquet, Audrey Favrelle, Lydie Pelinski, Pascal Gerbaux, and Philippe Zinck. 2019. “Synthesis of Levulinic Acid Based Poly(amine-co-ester)s.” Green Chemistry 21 (1): 123–128.
APA
Bernhard, Y., Pagies, L., Pellegrini, S., Bousquet, T., Favrelle, A., Pelinski, L., Gerbaux, P., et al. (2019). Synthesis of levulinic acid based poly(amine-co-ester)s. GREEN CHEMISTRY, 21(1), 123–128.
Vancouver
1.
Bernhard Y, Pagies L, Pellegrini S, Bousquet T, Favrelle A, Pelinski L, et al. Synthesis of levulinic acid based poly(amine-co-ester)s. GREEN CHEMISTRY. 2019;21(1):123–8.
MLA
Bernhard, Yann et al. “Synthesis of Levulinic Acid Based Poly(amine-co-ester)s.” GREEN CHEMISTRY 21.1 (2019): 123–128. Print.
@article{8612117,
  abstract     = {Four novel biobased monomers (i.e. two diesters and two hydroxyesters) bearing a tertiary amine in their backbone have been synthesized from the sustainable methyl levulinate and amino-alcohols/amino-esters derived from natural amino acids. Their homopolymerization/copolymerization with diols leads to six poly(amine-co-ester)s with various microstructures. These families of biodegradable polyesters have been reported to be efficient carriers for gene delivery. The polymers are carefully characterized by nuclear magnetic resonance spectroscopy (H-1 and C-13 NMR) and size exclusion chromatography (SEC), and exhibit molecular weights (M-n) up to 36 kg mol(-1) and dispersities (D) between 1.5 and 2.1. They also present good solubility in aqueous acidic media due to amine protonation. Such properties are promising for applications in the biomedical field or in personal care products.},
  author       = {Bernhard, Yann and Pagies, Lucas and Pellegrini, Sylvain and Bousquet, Till and Favrelle, Audrey and Pelinski, Lydie and Gerbaux, Pascal and Zinck, Philippe},
  issn         = {1463-9262},
  journal      = {GREEN CHEMISTRY},
  keywords     = {RING-OPENING POLYMERIZATION,GENE DELIVERY-SYSTEM,ALIPHATIC POLYESTERS,PARALLEL SYNTHESIS,NONVIRAL VECTORS,LIBRARY,COPOLYMER,CHEMICALS,MICELLES,PLATFORM},
  language     = {eng},
  number       = {1},
  pages        = {123--128},
  title        = {Synthesis of levulinic acid based poly(amine-co-ester)s},
  url          = {http://dx.doi.org/10.1039/c8gc03264e},
  volume       = {21},
  year         = {2019},
}

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