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Influence of extended dwell time during pre- and main compression on the properties of ibuprofen tablets

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Abstract
The low melting point, poor flow, physico-mechanical properties (particle size distribution, shape, particle surface roughness) and deformation mechanism of ibuprofen in combination with its high dose in tablets all contribute to the problems observed during the compaction of ibuprofen-based formulations. Since ibuprofen is plastically and elastically deforming, the rate of compaction plays an important role in both the final tablet properties and the risk of capping, laminating and sticking to the punches. While the compaction rate in most tableting machines is only determined by the tableting speed, the high speed rotary tableting machine used in this research project (MODUL (TM) P, GEA Process Engineering, Halle, Belgium) can adjust and control the dwell time independently from the tableting speed, using an air compensator which allows displacement of the upper (pre-) compression roller. The effect of this machine design on process parameters and tablet properties was investigated. Granules containing 80% ibuprofen were compressed into tablets at 250, 500 and 1000 tablets per minute via double compression (pre- and main compression) with or without extended dwell time. Prior to tableting, granule properties were determined. Process parameters and tablet properties were analyzed using Multivariate Data Analysis. Principal Component Analysis provided an overview of the main phenomena determining the tableting process and Partial Least Squares Analysis unveiled the main variables contributing to the observed differences in the tablet properties.
Keywords
Tableting, Rotary tablet press, Displacement, Force-time profile, Extended dwell time, Multivariate data analysis KeyWords Plus:ELASTIC RECOVERY, PHARMACEUTICAL SUBSTANCES, MECHANICAL STRENGTH, CRYSTAL HABIT, COMPACTION, PARAMETERS, FORCE, SPEED, BEHAVIOR, CURVES

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MLA
Peeters, Elisabeth, et al. “Influence of Extended Dwell Time during Pre- and Main Compression on the Properties of Ibuprofen Tablets.” EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 128, 2018, pp. 300–15, doi:10.1016/j.ejpb.2018.05.007.
APA
Peeters, E., Tavares da Silva, A., Fonteyne, M., De Beer, T., Vervaet, C., & Remon, J. P. (2018). Influence of extended dwell time during pre- and main compression on the properties of ibuprofen tablets. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 128, 300–315. https://doi.org/10.1016/j.ejpb.2018.05.007
Chicago author-date
Peeters, Elisabeth, Ana Tavares da Silva, Margot Fonteyne, Thomas De Beer, Chris Vervaet, and Jean Paul Remon. 2018. “Influence of Extended Dwell Time during Pre- and Main Compression on the Properties of Ibuprofen Tablets.” EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 128: 300–315. https://doi.org/10.1016/j.ejpb.2018.05.007.
Chicago author-date (all authors)
Peeters, Elisabeth, Ana Tavares da Silva, Margot Fonteyne, Thomas De Beer, Chris Vervaet, and Jean Paul Remon. 2018. “Influence of Extended Dwell Time during Pre- and Main Compression on the Properties of Ibuprofen Tablets.” EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 128: 300–315. doi:10.1016/j.ejpb.2018.05.007.
Vancouver
1.
Peeters E, Tavares da Silva A, Fonteyne M, De Beer T, Vervaet C, Remon JP. Influence of extended dwell time during pre- and main compression on the properties of ibuprofen tablets. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2018;128:300–15.
IEEE
[1]
E. Peeters, A. Tavares da Silva, M. Fonteyne, T. De Beer, C. Vervaet, and J. P. Remon, “Influence of extended dwell time during pre- and main compression on the properties of ibuprofen tablets,” EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 128, pp. 300–315, 2018.
@article{8611989,
  abstract     = {{The low melting point, poor flow, physico-mechanical properties (particle size distribution, shape, particle surface roughness) and deformation mechanism of ibuprofen in combination with its high dose in tablets all contribute to the problems observed during the compaction of ibuprofen-based formulations. Since ibuprofen is plastically and elastically deforming, the rate of compaction plays an important role in both the final tablet properties and the risk of capping, laminating and sticking to the punches. While the compaction rate in most tableting machines is only determined by the tableting speed, the high speed rotary tableting machine used in this research project (MODUL (TM) P, GEA Process Engineering, Halle, Belgium) can adjust and control the dwell time independently from the tableting speed, using an air compensator which allows displacement of the upper (pre-) compression roller. The effect of this machine design on process parameters and tablet properties was investigated. Granules containing 80% ibuprofen were compressed into tablets at 250, 500 and 1000 tablets per minute via double compression (pre- and main compression) with or without extended dwell time. Prior to tableting, granule properties were determined. Process parameters and tablet properties were analyzed using Multivariate Data Analysis. Principal Component Analysis provided an overview of the main phenomena determining the tableting process and Partial Least Squares Analysis unveiled the main variables contributing to the observed differences in the tablet properties.}},
  author       = {{Peeters, Elisabeth and Tavares da Silva, Ana and Fonteyne, Margot and De Beer, Thomas and Vervaet, Chris and Remon, Jean Paul}},
  issn         = {{0939-6411}},
  journal      = {{EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS}},
  keywords     = {{Tableting,Rotary tablet press,Displacement,Force-time profile,Extended dwell time,Multivariate data analysis   KeyWords Plus:ELASTIC RECOVERY,PHARMACEUTICAL SUBSTANCES,MECHANICAL STRENGTH,CRYSTAL HABIT,COMPACTION,PARAMETERS,FORCE,SPEED,BEHAVIOR,CURVES}},
  language     = {{eng}},
  pages        = {{300--315}},
  title        = {{Influence of extended dwell time during pre- and main compression on the properties of ibuprofen tablets}},
  url          = {{http://doi.org/10.1016/j.ejpb.2018.05.007}},
  volume       = {{128}},
  year         = {{2018}},
}

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