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Yeast-secreted, dried and food-admixed monomeric IgA prevents gastrointestinal infection in a piglet model

Vikram Virdi (UGent) , Jorge Palací Bataller (UGent) , Bram Laukens (UGent) , Stefan Ryckaert (UGent) , Eric Cox (UGent) , Erik Vanderbeke, Anna Depicker (UGent) and Nico Callewaert (UGent)
(2019) Nature Biotechnology. 37. p.527-530
Author
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Abstract
A scalably manufacturable oral antibody technology that can interfere with gastrointestinal (GI) targets is needed. Contrary to the complex native secretory IgA, we achieve this using a single-gene encoded monomeric-IgA-like antibody, composed of camelid VHH fused to IgA Fc (mVHH-IgA). This can be produced in soybean seeds or secreted from Pichia pastoris yeast, freeze- or spray-dried, and when delivered in food prevents enterotoxigenic Escherichia coli (F4-ETEC) infection in piglets.
Keywords
Biotechnology, Molecular Medicine, Applied Microbiology and Biotechnology, Bioengineering, Biomedical Engineering

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Chicago
Virdi, Vikram, Jorge Palací Bataller, Bram Laukens, Stefan Ryckaert, Eric Cox, Erik Vanderbeke, Anna Depicker, and Nico Callewaert. 2019. “Yeast-secreted, Dried and Food-admixed Monomeric IgA Prevents Gastrointestinal Infection in a Piglet Model.” Nature Biotechnology 37: 527–530.
APA
Virdi, V., Palací Bataller, J., Laukens, B., Ryckaert, S., Cox, E., Vanderbeke, E., Depicker, A., et al. (2019). Yeast-secreted, dried and food-admixed monomeric IgA prevents gastrointestinal infection in a piglet model. Nature Biotechnology, 37, 527–530.
Vancouver
1.
Virdi V, Palací Bataller J, Laukens B, Ryckaert S, Cox E, Vanderbeke E, et al. Yeast-secreted, dried and food-admixed monomeric IgA prevents gastrointestinal infection in a piglet model. Nature Biotechnology. Springer Nature; 2019;37:527–30.
MLA
Virdi, Vikram et al. “Yeast-secreted, Dried and Food-admixed Monomeric IgA Prevents Gastrointestinal Infection in a Piglet Model.” Nature Biotechnology 37 (2019): 527–530. Print.
@article{8611521,
  abstract     = {A scalably manufacturable oral antibody technology that can interfere with gastrointestinal (GI) targets is needed. Contrary to the complex native secretory IgA, we achieve this using a single-gene encoded monomeric-IgA-like antibody, composed of camelid VHH fused to IgA Fc (mVHH-IgA). This can be produced in soybean seeds or secreted from Pichia pastoris yeast, freeze- or spray-dried, and when delivered in food prevents enterotoxigenic Escherichia coli (F4-ETEC) infection in piglets. },
  author       = {Virdi, Vikram and Palac{\'i} Bataller, Jorge and Laukens, Bram and Ryckaert, Stefan and Cox, Eric and Vanderbeke, Erik and Depicker, Anna and Callewaert, Nico},
  issn         = {1087-0156},
  journal      = {Nature Biotechnology},
  language     = {eng},
  pages        = {527--530},
  publisher    = {Springer Nature},
  title        = {Yeast-secreted, dried and food-admixed monomeric IgA prevents gastrointestinal infection in a piglet model},
  url          = {http://dx.doi.org/10.1038/s41587-019-0070-x},
  volume       = {37},
  year         = {2019},
}

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