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Prefrontal and temporal cortical thickness in adolescents with traumatic brain injury

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Abstract
Aim: To investigate the impact of traumatic injury on the developing prefrontal-temporal adolescent cortex, and correlated brain structural measures with neurocognitive functioning. Method: Nineteen adolescents (12 males, 7 females, age range: 11-17y, mean 15y 8mo, standard deviation 1y 7mo, median 15y 11mo) with traumatic brain injury (TBI) were included. Cortical thickness of frontal and temporal lobes was assessed using magnetic resonance imaging. We correlated cortical thickness of prefrontal-temporal regions with age, time since injury, and neurocognitive functioning, and compared these results with a matched control cohort without TBI. Results: We found thinner prefrontal (p=0.039) and temporal cortices (p=0.002) in adolescents with TBI compared to typically developing children. Furthermore, significant age effect was observed on the prefrontal (r=-0.75, p=0.003) and temporal (r=-0.66, p=0.013) cortical thickness in typically developing adolescents, but not in adolescents with TBI. Executive function (measured using the Behaviour Rating Inventory of Executive Function questionnaire, with lower scores meaning higher functioning) was correlated with prefrontal cortical thickness in typically developing adolescents (r=0.72, p=0.009). Opposite trends were found for correlations between cortical thickness and executive function in the TBI and control cohort. Interpretation: Structural maturation in typically developing adolescents correlates with functional development: the older the adolescent, the thinner the prefrontal cortex, the better executive function. In adolescents with TBI we observed an opposite trend, that appeared significantly different from the control group: the thinner the prefrontal and temporal cortex, the worse executive functioning.
Keywords
LONGITUDINAL CHANGES, EXECUTIVE FUNCTIONS, CEREBRAL-CORTEX, SURFACE-AREA, CHILDHOOD, CHILDREN, LESIONS, SYSTEM

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MLA
Vander Linden, Catharine et al. “Prefrontal and Temporal Cortical Thickness in Adolescents with Traumatic Brain Injury.” DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY 61.2 (2019): 672–679. Print.
APA
Vander Linden, C., Verhelst, H., Verleysen, G., Caeyenberghs, K., Deblaere, K., & Vingerhoets, G. (2019). Prefrontal and temporal cortical thickness in adolescents with traumatic brain injury. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 61(2), 672–679.
Chicago author-date
Vander Linden, Catharine, Helena Verhelst, Gregory Verleysen, Karen Caeyenberghs, Karel Deblaere, and Guy Vingerhoets. 2019. “Prefrontal and Temporal Cortical Thickness in Adolescents with Traumatic Brain Injury.” Developmental Medicine and Child Neurology 61 (2): 672–679.
Chicago author-date (all authors)
Vander Linden, Catharine, Helena Verhelst, Gregory Verleysen, Karen Caeyenberghs, Karel Deblaere, and Guy Vingerhoets. 2019. “Prefrontal and Temporal Cortical Thickness in Adolescents with Traumatic Brain Injury.” Developmental Medicine and Child Neurology 61 (2): 672–679.
Vancouver
1.
Vander Linden C, Verhelst H, Verleysen G, Caeyenberghs K, Deblaere K, Vingerhoets G. Prefrontal and temporal cortical thickness in adolescents with traumatic brain injury. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. 2019;61(2):672–9.
IEEE
[1]
C. Vander Linden, H. Verhelst, G. Verleysen, K. Caeyenberghs, K. Deblaere, and G. Vingerhoets, “Prefrontal and temporal cortical thickness in adolescents with traumatic brain injury,” DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, vol. 61, no. 2, pp. 672–679, 2019.
@article{8611362,
  abstract     = {Aim: To investigate the impact of traumatic injury on the developing prefrontal-temporal adolescent cortex, and correlated brain structural measures with neurocognitive functioning.
Method: Nineteen adolescents (12 males, 7 females, age range: 11-17y, mean 15y 8mo, standard deviation 1y 7mo, median 15y 11mo) with traumatic brain injury (TBI) were included. Cortical thickness of frontal and temporal lobes was assessed using magnetic resonance imaging. We correlated cortical thickness of prefrontal-temporal regions with age, time since injury, and neurocognitive functioning, and compared these results with a matched control cohort without TBI.
Results: We found thinner prefrontal (p=0.039) and temporal cortices (p=0.002) in adolescents with TBI compared to typically developing children. Furthermore, significant age effect was observed on the prefrontal (r=-0.75, p=0.003) and temporal (r=-0.66, p=0.013) cortical thickness in typically developing adolescents, but not in adolescents with TBI. Executive function (measured using the Behaviour Rating Inventory of Executive Function questionnaire, with lower scores meaning higher functioning) was correlated with prefrontal cortical thickness in typically developing adolescents (r=0.72, p=0.009). Opposite trends were found for correlations between cortical thickness and executive function in the TBI and control cohort.
Interpretation: Structural maturation in typically developing adolescents correlates with functional development: the older the adolescent, the thinner the prefrontal cortex, the better executive function. In adolescents with TBI we observed an opposite trend, that appeared significantly different from the control group: the thinner the prefrontal and temporal cortex, the worse executive functioning.},
  author       = {Vander Linden, Catharine and Verhelst, Helena and Verleysen, Gregory and Caeyenberghs, Karen and Deblaere, Karel and Vingerhoets, Guy},
  issn         = {0012-1622},
  journal      = {DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY},
  keywords     = {LONGITUDINAL CHANGES,EXECUTIVE FUNCTIONS,CEREBRAL-CORTEX,SURFACE-AREA,CHILDHOOD,CHILDREN,LESIONS,SYSTEM},
  language     = {eng},
  number       = {2},
  pages        = {672--679},
  title        = {Prefrontal and temporal cortical thickness in adolescents with traumatic brain injury},
  url          = {http://dx.doi.org/10.1111/dmcn.14100},
  volume       = {61},
  year         = {2019},
}

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