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Biomarkers for exposure as a tool for efficacy testing of a mycotoxin detoxifier in broiler chickens and pigs

(2019) TOXINS. 11(4).
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Abstract
Applying post-harvest control measures such as adding mycotoxin detoxifying agents is a frequently-used mitigation strategy for mycotoxins. EFSA states that the efficacy of these detoxifiers needs to be tested using specific biomarkers for exposure. However, the proposed biomarkers for exposure are not further optimized for specific target species. Hence, the goal of this study was (a) to evaluate the most suitable biomarkers for deoxynivalenol (DON) and zearalenone (ZEN) in porcine plasma, urine and feces; and DON, aflatoxin B1 (AFB1) and ochratoxin A (OTA) in plasma and excreta of broiler chickens and (b) to determine the efficacy of a candidate detoxifier, as a proof-of-concept study. Therefore, a mixture of mycotoxins was administered as a single oral bolus with or without detoxifying agent. In accordance with literature AFB1, OTA, and DON-sulphate (DON-S) proved optimal biomarkers in broilers plasma and excreta whereas, in pigs DON-glucuronide (DON-GlcA) and ZEN-glucuronide (ZEN-GlcA) proved the optimal biomarkers in plasma, DON and ZEN-GlcA in urine and, ZEN in feces. A statistically significant reduction was seen between control and treatment group for both AFB1 and DON in broiler plasma, under administration of the mycotoxin blend and detoxifier dose studied suggesting thus, beneficial bioactivity.
Keywords
biomarkers, exposure, efficacy, mycotoxin detoxifier, pig, broiler chicken, FUSARIUM TOXIN DEOXYNIVALENOL, IN-VIVO EFFICACY, SODIUM BENTONITE, OCHRATOXIN-A, AFLATOXIN B-1, COMPARATIVE TOXICOKINETICS, OXIDATIVE STRESS, METABOLISM, ZEARALENONE, POULTRY

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Citation

Please use this url to cite or link to this publication:

Chicago
Lauwers, Marianne, Siska Croubels, Ben Letor, Christos Gougoulias, and Mathias Devreese. 2019. “Biomarkers for Exposure as a Tool for Efficacy Testing of a Mycotoxin Detoxifier in Broiler Chickens and Pigs.” Toxins 11 (4).
APA
Lauwers, M., Croubels, S., Letor, B., Gougoulias, C., & Devreese, M. (2019). Biomarkers for exposure as a tool for efficacy testing of a mycotoxin detoxifier in broiler chickens and pigs. TOXINS, 11(4).
Vancouver
1.
Lauwers M, Croubels S, Letor B, Gougoulias C, Devreese M. Biomarkers for exposure as a tool for efficacy testing of a mycotoxin detoxifier in broiler chickens and pigs. TOXINS. 2019;11(4).
MLA
Lauwers, Marianne et al. “Biomarkers for Exposure as a Tool for Efficacy Testing of a Mycotoxin Detoxifier in Broiler Chickens and Pigs.” TOXINS 11.4 (2019): n. pag. Print.
@article{8610947,
  abstract     = {Applying post-harvest control measures such as adding mycotoxin detoxifying agents is a frequently-used mitigation strategy for mycotoxins. EFSA states that the efficacy of these detoxifiers needs to be tested using specific biomarkers for exposure. However, the proposed biomarkers for exposure are not further optimized for specific target species. Hence, the goal of this study was (a) to evaluate the most suitable biomarkers for deoxynivalenol (DON) and zearalenone (ZEN) in porcine plasma, urine and feces; and DON, aflatoxin B1 (AFB1) and ochratoxin A (OTA) in plasma and excreta of broiler chickens and (b) to determine the efficacy of a candidate detoxifier, as a proof-of-concept study. Therefore, a mixture of mycotoxins was administered as a single oral bolus with or without detoxifying agent. In accordance with literature AFB1, OTA, and DON-sulphate (DON-S) proved optimal biomarkers in broilers plasma and excreta whereas, in pigs DON-glucuronide (DON-GlcA) and ZEN-glucuronide (ZEN-GlcA) proved the optimal biomarkers in plasma, DON and ZEN-GlcA in urine and, ZEN in feces. A statistically significant reduction was seen between control and treatment group for both AFB1 and DON in broiler plasma, under administration of the mycotoxin blend and detoxifier dose studied suggesting thus, beneficial bioactivity.},
  articleno    = {187},
  author       = {Lauwers, Marianne and Croubels, Siska and Letor, Ben and Gougoulias, Christos and Devreese, Mathias},
  issn         = {2072-6651},
  journal      = {TOXINS},
  keywords     = {biomarkers,exposure,efficacy,mycotoxin detoxifier,pig,broiler chicken,FUSARIUM TOXIN DEOXYNIVALENOL,IN-VIVO EFFICACY,SODIUM BENTONITE,OCHRATOXIN-A,AFLATOXIN B-1,COMPARATIVE TOXICOKINETICS,OXIDATIVE STRESS,METABOLISM,ZEARALENONE,POULTRY},
  language     = {eng},
  number       = {4},
  pages        = {23},
  title        = {Biomarkers for exposure as a tool for efficacy testing of a mycotoxin detoxifier in broiler chickens and pigs},
  url          = {http://dx.doi.org/10.3390/toxins11040187},
  volume       = {11},
  year         = {2019},
}

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