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Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

Davide De Francesco, Ferdinand W Wit, Alexander Bürkle, Sebastian Oehlke, Neeltje A Kootstra, Alan Winston, Claudio Franceschi, Paolo Garagnani, Chiara Pirazzini, Claude Libert (UGent) , et al.
(2019) AIDS. 33(2). p.259-268
Author
Organization
Abstract
Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH) may show signs of premature/accentuated aging. We compared established biomarkers of aging in PLWH, appropriately chosen HIV-negative individuals, and blood donors, and explored factors associated with biological age advancement. Design: Cross-sectional analysis of 134 PLWH on suppressive antiretroviral therapy, 79 lifestyle-comparable HIV-negative controls aged 45 years or older from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors. Methods: Biological age was estimated using a validated algorithm based on 10 biomarkers. Associations between ` age advancement' (biological minus chronological age) and HIV status/ parameters, lifestyle, cytomegalovirus (CMV), hepatitis B (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression. Results: The average (95% CI) age advancement was greater in both HIV-positive [13.2 (11.6-14.9) years] and HIV-negative [5.5 (3.8-7.2) years] COBRA participants compared with blood donors [-7.0 (-4.1 to -9.9) years, both P's< 0.001)], but also in HIV-positive compared with HIV-negative participants (P< 0.001). Chronic HBV, higher anti-CMV IgG titer and CD8 thorn T-cell count were each associated with increased age advancement, independently of HIV-status/ group. Among HIV-positive participants, age advancement was increased by 3.5 (0.1-6.8) years among those with nadir CD4 thorn T-cell count less than 200 cells/ ml and by 0.1 (0.06-0.2) years for each additional month of exposure to saquinavir. Conclusion: Both treated PLWH and lifestyle-comparable HIV-negative individuals show signs of age advancement compared with blood donors, to which persistent CMV, HBV co-infection and CD8(+) T-cell activation may have contributed. Age advancement remained greatest in PLWH and was related to prior immunodeficiency and cumulative saquinavir exposure.
Keywords
IMMUNOGLOBULIN-G ANTIBODY, INFECTED INDIVIDUALS, PROTEASE INHIBITORS, SOUTH-AFRICA, RISK-FACTORS, BIOMARKERS, DISEASE, CYTOMEGALOVIRUS, COMORBIDITIES, POPULATION, accelerated aging, aging, biological age, biomarkers of aging, HIV, premature aging

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MLA
De Francesco, Davide, et al. “Do People Living with HIV Experience Greater Age Advancement than Their HIV-Negative Counterparts?” AIDS, vol. 33, no. 2, 2019, pp. 259–68, doi:10.1097/QAD.0000000000002063.
APA
De Francesco, D., Wit, F. W., Bürkle, A., Oehlke, S., Kootstra, N. A., Winston, A., … Dewaele, S. (2019). Do people living with HIV experience greater age advancement than their HIV-negative counterparts? AIDS, 33(2), 259–268. https://doi.org/10.1097/QAD.0000000000002063
Chicago author-date
De Francesco, Davide, Ferdinand W Wit, Alexander Bürkle, Sebastian Oehlke, Neeltje A Kootstra, Alan Winston, Claudio Franceschi, et al. 2019. “Do People Living with HIV Experience Greater Age Advancement than Their HIV-Negative Counterparts?” AIDS 33 (2): 259–68. https://doi.org/10.1097/QAD.0000000000002063.
Chicago author-date (all authors)
De Francesco, Davide, Ferdinand W Wit, Alexander Bürkle, Sebastian Oehlke, Neeltje A Kootstra, Alan Winston, Claudio Franceschi, Paolo Garagnani, Chiara Pirazzini, Claude Libert, Tilman Grune, Daniela Weber, Eugene HJM Jansen, Caroline A Sabin, Peter Reiss, on behalf of the Co-morBidity in Relation to AIDS (COBRA) collaboration, and Sylviane Dewaele. 2019. “Do People Living with HIV Experience Greater Age Advancement than Their HIV-Negative Counterparts?” AIDS 33 (2): 259–268. doi:10.1097/QAD.0000000000002063.
Vancouver
1.
De Francesco D, Wit FW, Bürkle A, Oehlke S, Kootstra NA, Winston A, et al. Do people living with HIV experience greater age advancement than their HIV-negative counterparts? AIDS. 2019;33(2):259–68.
IEEE
[1]
D. De Francesco et al., “Do people living with HIV experience greater age advancement than their HIV-negative counterparts?,” AIDS, vol. 33, no. 2, pp. 259–268, 2019.
@article{8610670,
  abstract     = {{Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH) may show signs of premature/accentuated aging. We compared established biomarkers of aging in PLWH, appropriately chosen HIV-negative individuals, and blood donors, and explored factors associated with biological age advancement. 
Design: Cross-sectional analysis of 134 PLWH on suppressive antiretroviral therapy, 79 lifestyle-comparable HIV-negative controls aged 45 years or older from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors. 
Methods: Biological age was estimated using a validated algorithm based on 10 biomarkers. Associations between ` age advancement' (biological minus chronological age) and HIV status/ parameters, lifestyle, cytomegalovirus (CMV), hepatitis B (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression. 
Results: The average (95% CI) age advancement was greater in both HIV-positive [13.2 (11.6-14.9) years] and HIV-negative [5.5 (3.8-7.2) years] COBRA participants compared with blood donors [-7.0 (-4.1 to -9.9) years, both P's< 0.001)], but also in HIV-positive compared with HIV-negative participants (P< 0.001). Chronic HBV, higher anti-CMV IgG titer and CD8 thorn T-cell count were each associated with increased age advancement, independently of HIV-status/ group. Among HIV-positive participants, age advancement was increased by 3.5 (0.1-6.8) years among those with nadir CD4 thorn T-cell count less than 200 cells/ ml and by 0.1 (0.06-0.2) years for each additional month of exposure to saquinavir. 
Conclusion: Both treated PLWH and lifestyle-comparable HIV-negative individuals show signs of age advancement compared with blood donors, to which persistent CMV, HBV co-infection and CD8(+) T-cell activation may have contributed. Age advancement remained greatest in PLWH and was related to prior immunodeficiency and cumulative saquinavir exposure.}},
  author       = {{De Francesco, Davide and Wit, Ferdinand W and Bürkle, Alexander and Oehlke, Sebastian and Kootstra, Neeltje A and Winston, Alan and Franceschi, Claudio and Garagnani, Paolo and Pirazzini, Chiara and Libert, Claude and Grune, Tilman and Weber, Daniela and Jansen, Eugene HJM and Sabin, Caroline A and Reiss, Peter and Co-morBidity in Relation to AIDS (COBRA) collaboration, on behalf of the and Dewaele, Sylviane}},
  issn         = {{0269-9370}},
  journal      = {{AIDS}},
  keywords     = {{IMMUNOGLOBULIN-G ANTIBODY,INFECTED INDIVIDUALS,PROTEASE INHIBITORS,SOUTH-AFRICA,RISK-FACTORS,BIOMARKERS,DISEASE,CYTOMEGALOVIRUS,COMORBIDITIES,POPULATION,accelerated aging,aging,biological age,biomarkers of aging,HIV,premature aging}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{259--268}},
  title        = {{Do people living with HIV experience greater age advancement than their HIV-negative counterparts?}},
  url          = {{http://doi.org/10.1097/QAD.0000000000002063}},
  volume       = {{33}},
  year         = {{2019}},
}
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