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Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

(2019) AIDS. 33(2). p.259-268
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Abstract
Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH) may show signs of premature/accentuated aging. We compared established biomarkers of aging in PLWH, appropriately chosen HIV-negative individuals, and blood donors, and explored factors associated with biological age advancement. Design: Cross-sectional analysis of 134 PLWH on suppressive antiretroviral therapy, 79 lifestyle-comparable HIV-negative controls aged 45 years or older from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors. Methods: Biological age was estimated using a validated algorithm based on 10 biomarkers. Associations between ` age advancement' (biological minus chronological age) and HIV status/ parameters, lifestyle, cytomegalovirus (CMV), hepatitis B (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression. Results: The average (95% CI) age advancement was greater in both HIV-positive [13.2 (11.6-14.9) years] and HIV-negative [5.5 (3.8-7.2) years] COBRA participants compared with blood donors [-7.0 (-4.1 to -9.9) years, both P's< 0.001)], but also in HIV-positive compared with HIV-negative participants (P< 0.001). Chronic HBV, higher anti-CMV IgG titer and CD8 thorn T-cell count were each associated with increased age advancement, independently of HIV-status/ group. Among HIV-positive participants, age advancement was increased by 3.5 (0.1-6.8) years among those with nadir CD4 thorn T-cell count less than 200 cells/ ml and by 0.1 (0.06-0.2) years for each additional month of exposure to saquinavir. Conclusion: Both treated PLWH and lifestyle-comparable HIV-negative individuals show signs of age advancement compared with blood donors, to which persistent CMV, HBV co-infection and CD8(+) T-cell activation may have contributed. Age advancement remained greatest in PLWH and was related to prior immunodeficiency and cumulative saquinavir exposure.
Keywords
IMMUNOGLOBULIN-G ANTIBODY, INFECTED INDIVIDUALS, PROTEASE INHIBITORS, SOUTH-AFRICA, RISK-FACTORS, BIOMARKERS, DISEASE, CYTOMEGALOVIRUS, COMORBIDITIES, POPULATION, accelerated aging, aging, biological age, biomarkers of aging, HIV, premature aging

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Citation

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Chicago
De Francesco, Davide, Ferdinand W Wit, Alexander Bürkle, Sebastian Oehlke, Neeltje A Kootstra, Alan Winston, Claudio Franceschi, et al. 2019. “Do People Living with HIV Experience Greater Age Advancement Than Their HIV-negative Counterparts?” Aids 33 (2): 259–268.
APA
De Francesco, D., Wit, F. W., Bürkle, A., Oehlke, S., Kootstra, N. A., Winston, A., Franceschi, C., et al. (2019). Do people living with HIV experience greater age advancement than their HIV-negative counterparts? AIDS, 33(2), 259–268.
Vancouver
1.
De Francesco D, Wit FW, Bürkle A, Oehlke S, Kootstra NA, Winston A, et al. Do people living with HIV experience greater age advancement than their HIV-negative counterparts? AIDS. 2019;33(2):259–68.
MLA
De Francesco, Davide et al. “Do People Living with HIV Experience Greater Age Advancement Than Their HIV-negative Counterparts?” AIDS 33.2 (2019): 259–268. Print.
@article{8610670,
  abstract     = {Objectives: Despite successful antiretroviral therapy, people living with HIV (PLWH) may show signs of premature/accentuated aging. We compared established biomarkers of aging in PLWH, appropriately chosen HIV-negative individuals, and blood donors, and explored factors associated with biological age advancement. 
Design: Cross-sectional analysis of 134 PLWH on suppressive antiretroviral therapy, 79 lifestyle-comparable HIV-negative controls aged 45 years or older from the Co-morBidity in Relation to AIDS (COBRA) cohort, and 35 age-matched blood donors. 
Methods: Biological age was estimated using a validated algorithm based on 10 biomarkers. Associations between ` age advancement' (biological minus chronological age) and HIV status/ parameters, lifestyle, cytomegalovirus (CMV), hepatitis B (HBV) and hepatitis C virus (HCV) infections were investigated using linear regression. 
Results: The average (95\% CI) age advancement was greater in both HIV-positive [13.2 (11.6-14.9) years] and HIV-negative [5.5 (3.8-7.2) years] COBRA participants compared with blood donors [-7.0 (-4.1 to -9.9) years, both P's{\textlangle} 0.001)], but also in HIV-positive compared with HIV-negative participants (P{\textlangle} 0.001). Chronic HBV, higher anti-CMV IgG titer and CD8 thorn T-cell count were each associated with increased age advancement, independently of HIV-status/ group. Among HIV-positive participants, age advancement was increased by 3.5 (0.1-6.8) years among those with nadir CD4 thorn T-cell count less than 200 cells/ ml and by 0.1 (0.06-0.2) years for each additional month of exposure to saquinavir. 
Conclusion: Both treated PLWH and lifestyle-comparable HIV-negative individuals show signs of age advancement compared with blood donors, to which persistent CMV, HBV co-infection and CD8(+) T-cell activation may have contributed. Age advancement remained greatest in PLWH and was related to prior immunodeficiency and cumulative saquinavir exposure.},
  author       = {De Francesco, Davide and Wit, Ferdinand W and B{\"u}rkle, Alexander and Oehlke, Sebastian and Kootstra, Neeltje A and Winston, Alan and Franceschi, Claudio and Garagnani, Paolo and Pirazzini, Chiara and Libert, Claude and Grune, Tilman and Weber, Daniela and Jansen, Eugene HJM and Sabin, Caroline A and Reiss, Peter and Co-morBidity in Relation to AIDS (COBRA) collaboration, on behalf of the and Dewaele, Sylviane},
  issn         = {0269-9370},
  journal      = {AIDS},
  language     = {eng},
  number       = {2},
  pages        = {259--268},
  title        = {Do people living with HIV experience greater age advancement than their HIV-negative counterparts?},
  url          = {http://dx.doi.org/10.1097/QAD.0000000000002063},
  volume       = {33},
  year         = {2019},
}

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