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Emerging roles of innate lymphoid cells in inflammatory diseases : clinical implications

(2018) ALLERGY. 73(4). p.837-850
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Abstract
Innate lymphoid cells (ILC) represent a group of lymphocytes that lack specific antigen receptors and are relatively rare as compared to adaptive lymphocytes. ILCs play important roles in allergic and nonallergic inflammatory diseases due to their location at barrier surfaces within the airways, gut, and skin, and they respond to cytokines produced by activated cells in their local environment. Innate lymphoid cells contribute to the immune response by the release of cytokines and other mediators, forming a link between innate and adaptive immunity. In recent years, these cells have been extensively characterized and their role in animal models of disease has been investigated. Data to translate the relevance of ILCs in human pathology, and the potential role of ILCs in diagnosis, as biomarkers and/or as future treatment targets are also emerging. This review, produced by a task force of the Immunology Section of the European Academy of Allergy and Clinical Immunology (EAACI), encompassing clinicians and researchers, highlights the role of ILCs in human allergic and nonallergic diseases in the airways, gastrointestinal tract, and skin, with a focus on new insights into clinical implications, therapeutic options, and future research opportunities.
Keywords
inflammatory diseases, innate lymphoid cells, therapeutic targets, allergy, THYMIC STROMAL LYMPHOPOIETIN, CRTH2 ANTAGONIST OC000459, SEVERE ASTHMA, CROHNS-DISEASE, AIRWAY HYPERREACTIVITY, CHRONIC RHINOSINUSITIS, NASAL POLYPS, ATOPIC-DERMATITIS, DOUBLE-BLIND, EOSINOPHILIC ESOPHAGITIS

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Citation

Please use this url to cite or link to this publication:

MLA
Kortekaas Krohn, I et al. “Emerging Roles of Innate Lymphoid Cells in Inflammatory Diseases : Clinical Implications.” ALLERGY 73.4 (2018): 837–850. Print.
APA
Kortekaas Krohn, I., Shikhagaie, M., Golebski, K., Bernink, J., Breynaert, C., Creyns, B., Diamant, Z., et al. (2018). Emerging roles of innate lymphoid cells in inflammatory diseases : clinical implications. ALLERGY, 73(4), 837–850.
Chicago author-date
Kortekaas Krohn, I, MM Shikhagaie, K Golebski, JH Bernink, C Breynaert, B Creyns, Z Diamant, et al. 2018. “Emerging Roles of Innate Lymphoid Cells in Inflammatory Diseases : Clinical Implications.” Allergy 73 (4): 837–850.
Chicago author-date (all authors)
Kortekaas Krohn, I, MM Shikhagaie, K Golebski, JH Bernink, C Breynaert, B Creyns, Z Diamant, WJ Fokkens, Philippe Gevaert, P Hellings, RW Hendriks, L Klimek, J Mjösberg, H Morita, GS Ogg, L O’Mahony, J Schwarze, SF Seys, MH Shamji, and SM Bal. 2018. “Emerging Roles of Innate Lymphoid Cells in Inflammatory Diseases : Clinical Implications.” Allergy 73 (4): 837–850.
Vancouver
1.
Kortekaas Krohn I, Shikhagaie M, Golebski K, Bernink J, Breynaert C, Creyns B, et al. Emerging roles of innate lymphoid cells in inflammatory diseases : clinical implications. ALLERGY. 2018;73(4):837–50.
IEEE
[1]
I. Kortekaas Krohn et al., “Emerging roles of innate lymphoid cells in inflammatory diseases : clinical implications,” ALLERGY, vol. 73, no. 4, pp. 837–850, 2018.
@article{8609408,
  abstract     = {Innate lymphoid cells (ILC) represent a group of lymphocytes that lack specific antigen receptors and are relatively rare as compared to adaptive lymphocytes. ILCs play important roles in allergic and nonallergic inflammatory diseases due to their location at barrier surfaces within the airways, gut, and skin, and they respond to cytokines produced by activated cells in their local environment. Innate lymphoid cells contribute to the immune response by the release of cytokines and other mediators, forming a link between innate and adaptive immunity. In recent years, these cells have been extensively characterized and their role in animal models of disease has been investigated. Data to translate the relevance of ILCs in human pathology, and the potential role of ILCs in diagnosis, as biomarkers and/or as future treatment targets are also emerging. This review, produced by a task force of the Immunology Section of the European Academy of Allergy and Clinical Immunology (EAACI), encompassing clinicians and researchers, highlights the role of ILCs in human allergic and nonallergic diseases in the airways, gastrointestinal tract, and skin, with a focus on new insights into clinical implications, therapeutic options, and future research opportunities.},
  author       = {Kortekaas Krohn, I and Shikhagaie, MM and Golebski, K and Bernink, JH and Breynaert, C and Creyns, B and Diamant, Z and Fokkens, WJ and Gevaert, Philippe and Hellings, P and Hendriks, RW and Klimek, L and Mjösberg, J and Morita, H and Ogg, GS and O'Mahony, L and Schwarze, J and Seys, SF and Shamji, MH and Bal, SM},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keywords     = {inflammatory diseases,innate lymphoid cells,therapeutic targets,allergy,THYMIC STROMAL LYMPHOPOIETIN,CRTH2 ANTAGONIST OC000459,SEVERE ASTHMA,CROHNS-DISEASE,AIRWAY HYPERREACTIVITY,CHRONIC RHINOSINUSITIS,NASAL POLYPS,ATOPIC-DERMATITIS,DOUBLE-BLIND,EOSINOPHILIC ESOPHAGITIS},
  language     = {eng},
  number       = {4},
  pages        = {837--850},
  title        = {Emerging roles of innate lymphoid cells in inflammatory diseases : clinical implications},
  url          = {http://dx.doi.org/10.1111/all.13340},
  volume       = {73},
  year         = {2018},
}

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