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Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model

Author
Organization
Abstract
Heterogeneity of cardiac tissue is an important factor determining the initiation and dynamics of cardiac arrhythmias. In this paper, we studied the effects of gradients of electrophysiological heterogeneity on reentrant excitation patterns using computer simulations. We investigated the dynamics of spiral waves in a two-dimensional sheet of cardiac tissue described by the Luo-Rudy phase 1 (LR1) ventricular action potential model. A gradient of action potential duration (APD) was imposed by gradually varying the local current density of K+ current or inward rectifying K+ current along one axis of the tissue sheet. We show that a gradient of APD resulted in spiral wave drift. This drift consisted of two components. The longitudinal (along the gradient) component was always directed toward regions of longer spiral wave period. The transverse (perpendicular to the gradient) component had a direction dependent on the direction of rotation of the spiral wave. We estimated the velocity of the drift as a function of the magnitude of the gradient and discuss its implications.
Keywords
SPIRAL WAVES, ELECTRICAL HETEROGENEITY, I-KR, MUSCLE, FIBRILLATION, REPOLARIZATION, EXCITATION, MECHANISMS, INSTABILITY, CONTRIBUTES, ionic model, spiral wave, reentrant arrhythmias, tissue heterogeneity

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MLA
Ten Tusscher, KHWJ, and Alexander Panfilov. “Reentry in Heterogeneous Cardiac Tissue Described by the Luo-Rudy Ventricular Action Potential Model.” AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 284.2 (2003): H542–H548. Print.
APA
Ten Tusscher, K., & Panfilov, A. (2003). Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 284(2), H542–H548.
Chicago author-date
Ten Tusscher, KHWJ, and Alexander Panfilov. 2003. “Reentry in Heterogeneous Cardiac Tissue Described by the Luo-Rudy Ventricular Action Potential Model.” American Journal of Physiology-heart and Circulatory Physiology 284 (2): H542–H548.
Chicago author-date (all authors)
Ten Tusscher, KHWJ, and Alexander Panfilov. 2003. “Reentry in Heterogeneous Cardiac Tissue Described by the Luo-Rudy Ventricular Action Potential Model.” American Journal of Physiology-heart and Circulatory Physiology 284 (2): H542–H548.
Vancouver
1.
Ten Tusscher K, Panfilov A. Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2003;284(2):H542–H548.
IEEE
[1]
K. Ten Tusscher and A. Panfilov, “Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model,” AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, vol. 284, no. 2, pp. H542–H548, 2003.
@article{8608607,
  abstract     = {Heterogeneity of cardiac tissue is an important factor determining the initiation and dynamics of cardiac arrhythmias. In this paper, we studied the effects of gradients of electrophysiological heterogeneity on reentrant excitation patterns using computer simulations. We investigated the dynamics of spiral waves in a two-dimensional sheet of cardiac tissue described by the Luo-Rudy phase 1 (LR1) ventricular action potential model. A gradient of action potential duration (APD) was imposed by gradually varying the local current density of K+ current or inward rectifying K+ current along one axis of the tissue sheet. We show that a gradient of APD resulted in spiral wave drift. This drift consisted of two components. The longitudinal (along the gradient) component was always directed toward regions of longer spiral wave period. The transverse (perpendicular to the gradient) component had a direction dependent on the direction of rotation of the spiral wave. We estimated the velocity of the drift as a function of the magnitude of the gradient and discuss its implications.},
  author       = {Ten Tusscher, KHWJ and Panfilov, Alexander},
  issn         = {0363-6135},
  journal      = {AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY},
  keywords     = {SPIRAL WAVES,ELECTRICAL HETEROGENEITY,I-KR,MUSCLE,FIBRILLATION,REPOLARIZATION,EXCITATION,MECHANISMS,INSTABILITY,CONTRIBUTES,ionic model,spiral wave,reentrant arrhythmias,tissue heterogeneity},
  language     = {eng},
  number       = {2},
  pages        = {H542--H548},
  title        = {Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model},
  url          = {http://dx.doi.org/10.1152/ajpheart.00608.2002},
  volume       = {284},
  year         = {2003},
}

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