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Pacemakers in a reaction-diffusion mechanics system

(2007) JOURNAL OF STATISTICAL PHYSICS. 128(1-2). p.375-392
Author
Organization
Abstract
Non-linear waves of excitation are found in various biological, physical and chemical systems and are often accompanied by deformations of the medium. In this paper, we numerically study wave propagation in a deforming excitable medium using a two-variable reaction-diffusion system coupled with equations of continuum mechanics. We study the appearance and dynamics of different excitation patterns organized by pacemakers that occur in the medium as a result of deformation. We also study the interaction of several pacemakers with each other and the characteristics of pacemakers in the presence of heterogeneities in the medium. We found that mechanical deformation not only induces pacemakers, but also has a pronounced effect on spatial organization of various excitation patterns. We show how these effects are modulated by the size of the medium, the location of the initial stimulus, and the properties of the reaction-diffusion-mechanics feedback.
Keywords
WAVE-PROPAGATION, CARDIAC-MUSCLE, SPIRAL WAVES, MODEL, STRETCH, HEART, ARRHYTHMIAS, TISSUE, FIBRILLATION, CHANNELS, reaction-diffusion-systems, oscillations, modeling in biology, pattern, formation, continuum mechanics, excitation-contraction-coupling, mechano-electrical feedback

Citation

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Chicago
Keldermann, RH, MP Nash, and Alexander Panfilov. 2007. “Pacemakers in a Reaction-diffusion Mechanics System.” Journal of Statistical Physics 128 (1-2): 375–392.
APA
Keldermann, R., Nash, M., & Panfilov, A. (2007). Pacemakers in a reaction-diffusion mechanics system. JOURNAL OF STATISTICAL PHYSICS, 128(1-2), 375–392. Presented at the Workshop on Applications of Methods of Stochastic Systems and Statistical Physics in Biology.
Vancouver
1.
Keldermann R, Nash M, Panfilov A. Pacemakers in a reaction-diffusion mechanics system. JOURNAL OF STATISTICAL PHYSICS. 2007;128(1-2):375–92.
MLA
Keldermann, RH, MP Nash, and Alexander Panfilov. “Pacemakers in a Reaction-diffusion Mechanics System.” JOURNAL OF STATISTICAL PHYSICS 128.1-2 (2007): 375–392. Print.
@article{8608450,
  abstract     = {Non-linear waves of excitation are found in various biological, physical and chemical systems and are often accompanied by deformations of the medium. In this paper, we numerically study wave propagation in a deforming excitable medium using a two-variable reaction-diffusion system coupled with equations of continuum mechanics. We study the appearance and dynamics of different excitation patterns organized by pacemakers that occur in the medium as a result of deformation. We also study the interaction of several pacemakers with each other and the characteristics of pacemakers in the presence of heterogeneities in the medium. We found that mechanical deformation not only induces pacemakers, but also has a pronounced effect on spatial organization of various excitation patterns. We show how these effects are modulated by the size of the medium, the location of the initial stimulus, and the properties of the reaction-diffusion-mechanics feedback.},
  author       = {Keldermann, RH and Nash, MP and Panfilov, Alexander},
  issn         = {0022-4715},
  journal      = {JOURNAL OF STATISTICAL PHYSICS},
  keywords     = {WAVE-PROPAGATION,CARDIAC-MUSCLE,SPIRAL WAVES,MODEL,STRETCH,HEART,ARRHYTHMIAS,TISSUE,FIBRILLATION,CHANNELS,reaction-diffusion-systems,oscillations,modeling in biology,pattern,formation,continuum mechanics,excitation-contraction-coupling,mechano-electrical feedback},
  language     = {eng},
  location     = {Notre Dame, IN, USA},
  number       = {1-2},
  pages        = {375--392},
  title        = {Pacemakers in a reaction-diffusion mechanics system},
  url          = {http://dx.doi.org/10.1007/s10955-006-9219-3},
  volume       = {128},
  year         = {2007},
}

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