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The seroprevalence of cytomegalovirus infection in Belgium anno 2002 and 2006 : a comparative analysis with hepatitis A virus seroprevalence

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Abstract
Cytomegalovirus (CMV) infection is endemic worldwide but its seroprevalence varies widely. The goal of this study was to estimate the age-specific seroprevalence of CMV infection in Belgium based on two cross-sectional serological datasets from 2002 and 2006. The seroprevalence was estimated relying on diagnostic test results based on cut-off values pre-specified by the manufacturers of the tests as well as relying on mixture models applied to continuous pathogen-specific immunoglobulin G antibody titre concentrations. The age-specific seroprevalence of hepatitis A virus (HAV), based on three Belgian cross-sectional serological datasets from 1993, 2002 and 2006, was used as a comparator since individuals acquire lifelong immunity upon recovery, implying an increasing seroprevalence with age. The age group weighted overall CMV seroprevalence derived from the mixture model was 32% (95% confidence interval (CI) 31–34%) in 2002 and 31% (95% CI 30–32%) in 2006. We demonstrated that CMV epidemiology differs from the immunizing infection HAV. This was the first large-scale study of CMV and HAV serial datasets in Belgium, estimating seroprevalence specified by age and birth cohort.
Keywords
Cytomegalovirus, hepatitis A virus, estimating age and birth cohort-specific seroprevalence, seroincidence, mixture modelling, WANING IMMUNITY, MIXTURE-MODELS, SEROEPIDEMIOLOGY, ANTIBODY, RUBELLA, PREVALENCE, VACCINATION, PERTUSSIS, EPIDEMIC, ENGLAND

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MLA
Smit, Suzanne et al. “The Seroprevalence of Cytomegalovirus Infection in Belgium Anno 2002 and 2006 : a Comparative Analysis with Hepatitis A Virus Seroprevalence.” EPIDEMIOLOGY AND INFECTION 147 (2019): n. pag. Print.
APA
Smit, S., Abrams, S., Dorny, P., Speybroeck, N., Devleesschauwer, B., Hutse, V., Jansens, H., et al. (2019). The seroprevalence of cytomegalovirus infection in Belgium anno 2002 and 2006 : a comparative analysis with hepatitis A virus seroprevalence. EPIDEMIOLOGY AND INFECTION, 147.
Chicago author-date
Smit, Suzanne, Steven Abrams, Pierre Dorny, Niko Speybroeck, Brecht Devleesschauwer, Veronik Hutse, Hilde Jansens, Heidi Theeten, Philippe Beutels, and Niel Hens. 2019. “The Seroprevalence of Cytomegalovirus Infection in Belgium Anno 2002 and 2006 : a Comparative Analysis with Hepatitis A Virus Seroprevalence.” Epidemiology and Infection 147.
Chicago author-date (all authors)
Smit, Suzanne, Steven Abrams, Pierre Dorny, Niko Speybroeck, Brecht Devleesschauwer, Veronik Hutse, Hilde Jansens, Heidi Theeten, Philippe Beutels, and Niel Hens. 2019. “The Seroprevalence of Cytomegalovirus Infection in Belgium Anno 2002 and 2006 : a Comparative Analysis with Hepatitis A Virus Seroprevalence.” Epidemiology and Infection 147.
Vancouver
1.
Smit S, Abrams S, Dorny P, Speybroeck N, Devleesschauwer B, Hutse V, et al. The seroprevalence of cytomegalovirus infection in Belgium anno 2002 and 2006 : a comparative analysis with hepatitis A virus seroprevalence. EPIDEMIOLOGY AND INFECTION. 2019;147.
IEEE
[1]
S. Smit et al., “The seroprevalence of cytomegalovirus infection in Belgium anno 2002 and 2006 : a comparative analysis with hepatitis A virus seroprevalence,” EPIDEMIOLOGY AND INFECTION, vol. 147, 2019.
@article{8608250,
  abstract     = {Cytomegalovirus (CMV) infection is endemic worldwide but its seroprevalence varies widely. The goal of this study was to estimate the age-specific seroprevalence of CMV infection in Belgium based on two cross-sectional serological datasets from 2002 and 2006. The seroprevalence was estimated relying on diagnostic test results based on cut-off values pre-specified by the manufacturers of the tests as well as relying on mixture models applied to continuous pathogen-specific immunoglobulin G antibody titre concentrations. The age-specific seroprevalence of hepatitis A virus (HAV), based on three Belgian cross-sectional serological datasets from 1993, 2002 and 2006, was used as a comparator since individuals acquire lifelong immunity upon recovery, implying an increasing seroprevalence with age. The age group weighted overall CMV seroprevalence derived from the mixture model was 32% (95% confidence interval (CI) 31–34%) in 2002 and 31% (95% CI 30–32%) in 2006. We demonstrated that CMV epidemiology differs from the immunizing infection HAV. This was the first large-scale study of CMV and HAV serial datasets in Belgium, estimating seroprevalence specified by age and birth cohort.},
  articleno    = {e154},
  author       = {Smit, Suzanne and Abrams, Steven and Dorny, Pierre and Speybroeck, Niko and Devleesschauwer, Brecht and Hutse, Veronik and Jansens, Hilde and Theeten, Heidi and Beutels, Philippe and Hens, Niel},
  issn         = {0950-2688},
  journal      = {EPIDEMIOLOGY AND INFECTION},
  keywords     = {Cytomegalovirus,hepatitis A virus,estimating age and birth cohort-specific seroprevalence,seroincidence,mixture modelling,WANING IMMUNITY,MIXTURE-MODELS,SEROEPIDEMIOLOGY,ANTIBODY,RUBELLA,PREVALENCE,VACCINATION,PERTUSSIS,EPIDEMIC,ENGLAND},
  language     = {eng},
  pages        = {9},
  title        = {The seroprevalence of cytomegalovirus infection in Belgium anno 2002 and 2006 : a comparative analysis with hepatitis A virus seroprevalence},
  url          = {http://dx.doi.org/10.1017/s0950268819000487},
  volume       = {147},
  year         = {2019},
}

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