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Abstract
During ageing, the secretory patterns of the hormones produced by the hypothalamic-pituitary axis change, as does the sensitivity of the axis to negative feedback by end hormones. Additionally, glucose homoeostasis tends towards disequilibrium with increasing age. Along with these endocrine alterations, a loss of bone and muscle mass and strength occurs, coupled with an increase in fat mass. In addition, ageing-induced effects are difficult to disentangle from the influence of other factors that are common in older people, such as chronic diseases, inflammation, and low nutritional status, all of which can also affect endocrine systems. Traditionally, the decrease in hormone activity during the ageing process has been considered to be detrimental because of the related decline in bodily functions. The concept of hormone replacement therapy was suggested as a therapeutic intervention to stop or reverse this decline. However, clearly some of these changes are a beneficial adaptation to ageing, whereas hormonal intervention often causes important adverse effects. In this paper, we discuss the effects of age on the different hypothalamic-pituitary-hormonal organ axes, as well as age-related changes in calcium and bone metabolism and glucose homoeostasis.
Keywords
SUBCLINICAL THYROID-DYSFUNCTION, INSULIN-SECRETION, GLUCOSE-TOLERANCE, DEHYDROEPIANDROSTERONE DHEA, POSTMENOPAUSAL WOMEN, HORMONE-THERAPY, ANDROGEN LEVELS, FREE-THYROXINE, RENAL-FUNCTION, FRACTURE RISK

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Chicago
van den Beld, Annewieke W, Jean Kaufman, M Carola Zillikens, Steven WJ Lamberts, Josephine M Egan, and Aart J van der Lely. 2018. “The Physiology of Endocrine Systems with Ageing.” Lancet Diabetes & Endocrinology 6 (8): 647–658.
APA
van den Beld, A. W., Kaufman, J., Zillikens, M. C., Lamberts, S. W., Egan, J. M., & van der Lely, A. J. (2018). The physiology of endocrine systems with ageing. LANCET DIABETES & ENDOCRINOLOGY, 6(8), 647–658.
Vancouver
1.
van den Beld AW, Kaufman J, Zillikens MC, Lamberts SW, Egan JM, van der Lely AJ. The physiology of endocrine systems with ageing. LANCET DIABETES & ENDOCRINOLOGY. 2018;6(8):647–58.
MLA
van den Beld, Annewieke W et al. “The Physiology of Endocrine Systems with Ageing.” LANCET DIABETES & ENDOCRINOLOGY 6.8 (2018): 647–658. Print.
@article{8607955,
  abstract     = {During ageing, the secretory patterns of the hormones produced by the hypothalamic-pituitary axis change, as does the sensitivity of the axis to negative feedback by end hormones. Additionally, glucose homoeostasis tends towards disequilibrium with increasing age. Along with these endocrine alterations, a loss of bone and muscle mass and strength occurs, coupled with an increase in fat mass. In addition, ageing-induced effects are difficult to disentangle from the influence of other factors that are common in older people, such as chronic diseases, inflammation, and low nutritional status, all of which can also affect endocrine systems. Traditionally, the decrease in hormone activity during the ageing process has been considered to be detrimental because of the related decline in bodily functions. The concept of hormone replacement therapy was suggested as a therapeutic intervention to stop or reverse this decline. However, clearly some of these changes are a beneficial adaptation to ageing, whereas hormonal intervention often causes important adverse effects. In this paper, we discuss the effects of age on the different hypothalamic-pituitary-hormonal organ axes, as well as age-related changes in calcium and bone metabolism and glucose homoeostasis.},
  author       = {van den Beld, Annewieke W and Kaufman, Jean and Zillikens, M Carola and Lamberts, Steven WJ and Egan, Josephine M and van der Lely, Aart J},
  issn         = {2213-8587},
  journal      = {LANCET DIABETES \& ENDOCRINOLOGY},
  language     = {eng},
  number       = {8},
  pages        = {647--658},
  title        = {The physiology of endocrine systems with ageing},
  url          = {http://dx.doi.org/10.1016/S2213-8587(18)30026-3},
  volume       = {6},
  year         = {2018},
}

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