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Calcium, a pivotal player in photodynamic therapy?

Delphine Hoorelbeke (UGent) , Elke Decrock (UGent) , Valérie Van Haver (UGent) , Marijke De Bock (UGent) and Luc Leybaert (UGent)
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Abstract
Photodynamic therapy combines three non-toxic components: light, oxygen and a photosensitizer to generate singlet oxygen and/or other ROS molecules in order to target destruction of cancer cells. The damage induced in the targeted cells can furthermore propagate to non-exposed bystander cells thereby exacerbating the damage. Ca2+ signaling is strongly intertwined with ROS signaling and both play crucial roles in cell death. In this review we aimed to review current knowledge on the role of Ca2+ and ROS signaling, their effect on cell-cell propagation via connexin-linked mechanisms and the outcome in terms of cell death. In general, photodynamic therapy results in an increased cytosolic Ca2+ concentration originating from Ca2+ entry or Ca2+ release from internal stores. While photodynamic therapy can certainly induce cell death, the outcome depends on the cell type and the photosensitizer used. Connexin channels propagating the Ca2+ signal, and presumably regenerating ROS at distance, may play a role in spreading the effect to neighboring non-exposed bystander cells. Given the various cell types and photosensitizers used, there is currently no unified signaling scheme to explain the role of Ca2+ and connexins in the responses following photodynamic therapy. This article is part of a Special Issue entitled: Calcium signaling in health, disease and therapy edited by Geert Bultynck and Jan Parys.
Keywords
Photodynamic therapy Bystander signaling Connexin Calcium signaling

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Chicago
Hoorelbeke, Delphine, Elke Decrock, Valérie Van Haver, Marijke De Bock, and Luc Leybaert. 2018. “Calcium, a Pivotal Player in Photodynamic Therapy?” Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research 1865 (11): 1805–1814.
APA
Hoorelbeke, D., Decrock, E., Van Haver, V., De Bock, M., & Leybaert, L. (2018). Calcium, a pivotal player in photodynamic therapy? Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1865(11), 1805–1814.
Vancouver
1.
Hoorelbeke D, Decrock E, Van Haver V, De Bock M, Leybaert L. Calcium, a pivotal player in photodynamic therapy? Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. Elsevier BV; 2018;1865(11):1805–14.
MLA
Hoorelbeke, Delphine et al. “Calcium, a Pivotal Player in Photodynamic Therapy?” Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865.11 (2018): 1805–1814. Print.
@article{8607707,
  abstract     = {Photodynamic therapy combines three non-toxic components: light, oxygen and a photosensitizer to generate
singlet oxygen and/or other ROS molecules in order to target destruction of cancer cells. The damage induced in
the targeted cells can furthermore propagate to non-exposed bystander cells thereby exacerbating the damage.
Ca2+ signaling is strongly intertwined with ROS signaling and both play crucial roles in cell death. In this review
we aimed to review current knowledge on the role of Ca2+ and ROS signaling, their effect on cell-cell propagation
via connexin-linked mechanisms and the outcome in terms of cell death. In general, photodynamic
therapy results in an increased cytosolic Ca2+ concentration originating from Ca2+ entry or Ca2+ release from
internal stores. While photodynamic therapy can certainly induce cell death, the outcome depends on the cell
type and the photosensitizer used. Connexin channels propagating the Ca2+ signal, and presumably regenerating
ROS at distance, may play a role in spreading the effect to neighboring non-exposed bystander cells. Given the
various cell types and photosensitizers used, there is currently no unified signaling scheme to explain the role of
Ca2+ and connexins in the responses following photodynamic therapy. This article is part of a Special Issue
entitled: Calcium signaling in health, disease and therapy edited by Geert Bultynck and Jan Parys.},
  author       = {Hoorelbeke, Delphine and Decrock, Elke and Van Haver, Val{\'e}rie and De Bock, Marijke and Leybaert, Luc},
  issn         = {0167-4889},
  journal      = {Biochimica et Biophysica Acta (BBA) - Molecular Cell Research},
  number       = {11},
  pages        = {1805--1814},
  publisher    = {Elsevier BV},
  title        = {Calcium, a pivotal player in photodynamic therapy?},
  url          = {http://dx.doi.org/10.1016/j.bbamcr.2018.07.022},
  volume       = {1865},
  year         = {2018},
}

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