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Connexins and pannexins in Alzheimer’s disease

(2019) NEUROSCIENCE LETTERS. 695. p.100-105
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Abstract
By 2040 neurodegenerative diseases will become the world's second leading cause of death after cardiovascular disease (WHO). Major efforts are required to elucidate the underlying molecular and cellular mechanisms of neurodegenerative diseases. Connexin and pannexin membrane channel proteins are conduits through which neuronal, glial, and vascular tissues interact. In the normal brain, this interaction underlies homeostasis, metabolic supply and neuroprotection. In models of neuroinflammation these channels present aberrant functioning. Validation of the molecular mechanisms by which these membrane channels influence neurodegeneration particularly in Alzheimer's disease could lead to new and alternative therapeutic strategies targeting these channels.
Keywords
Gap junctions, Connexin, Pannexin, Alzheimer's, Hemichannel, ENDOTHELIAL CALCIUM DYNAMICS, FUNCTIONAL GAP-JUNCTIONS, A-BETA-PLAQUES, MAST-CELLS, ENDOPLASMIC-RETICULUM, AMYLOID PLAQUES, MIMETIC PEPTIDE, CLEAVAGE SITE, ATP RELEASE, GLIAL-CELLS

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MLA
Giaume, Christian, et al. “Connexins and Pannexins in Alzheimer’s Disease.” NEUROSCIENCE LETTERS, vol. 695, 2019, pp. 100–05, doi:10.1016/j.neulet.2017.09.006.
APA
Giaume, C., Sáez, J. C., Song, W., Leybaert, L., & Naus, C. C. (2019). Connexins and pannexins in Alzheimer’s disease. NEUROSCIENCE LETTERS, 695, 100–105. https://doi.org/10.1016/j.neulet.2017.09.006
Chicago author-date
Giaume, Christian, Juan C Sáez, Weihong Song, Luc Leybaert, and Christian C. Naus. 2019. “Connexins and Pannexins in Alzheimer’s Disease.” NEUROSCIENCE LETTERS 695: 100–105. https://doi.org/10.1016/j.neulet.2017.09.006.
Chicago author-date (all authors)
Giaume, Christian, Juan C Sáez, Weihong Song, Luc Leybaert, and Christian C. Naus. 2019. “Connexins and Pannexins in Alzheimer’s Disease.” NEUROSCIENCE LETTERS 695: 100–105. doi:10.1016/j.neulet.2017.09.006.
Vancouver
1.
Giaume C, Sáez JC, Song W, Leybaert L, Naus CC. Connexins and pannexins in Alzheimer’s disease. NEUROSCIENCE LETTERS. 2019;695:100–5.
IEEE
[1]
C. Giaume, J. C. Sáez, W. Song, L. Leybaert, and C. C. Naus, “Connexins and pannexins in Alzheimer’s disease,” NEUROSCIENCE LETTERS, vol. 695, pp. 100–105, 2019.
@article{8607680,
  abstract     = {{By 2040 neurodegenerative diseases will become the world's second leading cause of death after cardiovascular disease (WHO). Major efforts are required to elucidate the underlying molecular and cellular mechanisms of neurodegenerative diseases. Connexin and pannexin membrane channel proteins are conduits through which neuronal, glial, and vascular tissues interact. In the normal brain, this interaction underlies homeostasis, metabolic supply and neuroprotection. In models of neuroinflammation these channels present aberrant functioning. Validation of the molecular mechanisms by which these membrane channels influence neurodegeneration particularly in Alzheimer's disease could lead to new and alternative therapeutic strategies targeting these channels.}},
  author       = {{Giaume, Christian and Sáez, Juan C and Song, Weihong and Leybaert, Luc and Naus, Christian C.}},
  issn         = {{0304-3940}},
  journal      = {{NEUROSCIENCE LETTERS}},
  keywords     = {{Gap junctions,Connexin,Pannexin,Alzheimer's,Hemichannel,ENDOTHELIAL CALCIUM DYNAMICS,FUNCTIONAL GAP-JUNCTIONS,A-BETA-PLAQUES,MAST-CELLS,ENDOPLASMIC-RETICULUM,AMYLOID PLAQUES,MIMETIC PEPTIDE,CLEAVAGE SITE,ATP RELEASE,GLIAL-CELLS}},
  language     = {{eng}},
  pages        = {{100--105}},
  title        = {{Connexins and pannexins in Alzheimer’s disease}},
  url          = {{http://doi.org/10.1016/j.neulet.2017.09.006}},
  volume       = {{695}},
  year         = {{2019}},
}

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