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Myocyte remodeling due to fibro-fatty infiltrations influences arrhythmogenicity

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Abstract
The onset of cardiac arrhythmias depends on the electrophysiological and structural properties of cardiac tissue. Electrophysiological remodeling of myocytes due to the presence of adipocytes constitutes a possibly important pathway in the pathogenesis of atrial fibrillation. In this paper we perform an in-silico study of the effect of such myocyte remodeling on the onset of atrial arrhythmias and study the dynamics of arrhythmia sources-spiral waves. We use the Courtemanche model for atrial myocytes and modify their electrophysiological properties based on published cellular electrophysiological measurements in myocytes co-cultered with adipocytes (a 69-87 % increase in APD90 and an increase of the RMP by 2.5-5.5 mV). In a generic 2D setup we show that adipose tissue remodeling substantially affects the spiral wave dynamics resulting in complex arrhythmia and such arrhythmia can be initiated under high frequency pacing if the size of the remodeled tissue is sufficiently large. These results are confirmed in simulations with an anatomically accurate model of the human atria.
Keywords
INDUCED ATRIAL-FIBRILLATION, MATHEMATICAL-MODEL, ADIPOSE-TISSUE, CARDIAC, TISSUE, K+ CURRENT, ELECTROPHYSIOLOGY, OBESITY, RISK, INSIGHTS, HEART, atrial fibrillation, adipose tissue, ionic modeling, arrhythmogenicity, computational modeling

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Citation

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Chicago
De Coster, Tim, Piet Claus, Gunnar Seemann, Rik Willems, Karin R Sipido, and Alexander Panfilov. 2018. “Myocyte Remodeling Due to Fibro-fatty Infiltrations Influences Arrhythmogenicity.” Frontiers in Physiology 9.
APA
De Coster, T., Claus, P., Seemann, G., Willems, R., Sipido, K. R., & Panfilov, A. (2018). Myocyte remodeling due to fibro-fatty infiltrations influences arrhythmogenicity. FRONTIERS IN PHYSIOLOGY, 9.
Vancouver
1.
De Coster T, Claus P, Seemann G, Willems R, Sipido KR, Panfilov A. Myocyte remodeling due to fibro-fatty infiltrations influences arrhythmogenicity. FRONTIERS IN PHYSIOLOGY. 2018;9.
MLA
De Coster, Tim et al. “Myocyte Remodeling Due to Fibro-fatty Infiltrations Influences Arrhythmogenicity.” FRONTIERS IN PHYSIOLOGY 9 (2018): n. pag. Print.
@article{8607023,
  abstract     = {The onset of cardiac arrhythmias depends on the electrophysiological and structural properties of cardiac tissue. Electrophysiological remodeling of myocytes due to the presence of adipocytes constitutes a possibly important pathway in the pathogenesis of atrial fibrillation. In this paper we perform an in-silico study of the effect of such myocyte remodeling on the onset of atrial arrhythmias and study the dynamics of arrhythmia sources-spiral waves. We use the Courtemanche model for atrial myocytes and modify their electrophysiological properties based on published cellular electrophysiological measurements in myocytes co-cultered with adipocytes (a 69-87 \% increase in APD90 and an increase of the RMP by 2.5-5.5 mV). In a generic 2D setup we show that adipose tissue remodeling substantially affects the spiral wave dynamics resulting in complex arrhythmia and such arrhythmia can be initiated under high frequency pacing if the size of the remodeled tissue is sufficiently large. These results are confirmed in simulations with an anatomically accurate model of the human atria.},
  articleno    = {1381},
  author       = {De Coster, Tim and Claus, Piet and Seemann, Gunnar and Willems, Rik and Sipido, Karin R and Panfilov, Alexander},
  issn         = {1664-042X},
  journal      = {FRONTIERS IN PHYSIOLOGY},
  language     = {eng},
  pages        = {13},
  title        = {Myocyte remodeling due to fibro-fatty infiltrations influences arrhythmogenicity},
  url          = {http://dx.doi.org/10.3389/fphys.2018.01381},
  volume       = {9},
  year         = {2018},
}

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