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Fox proteins are modular competency factors for facial cartilage and tooth specification

(2018) DEVELOPMENT. 145(12).
Author
Organization
Abstract
Facial form depends on the precise positioning of cartilage, bone, and tooth fields in the embryonic pharyngeal arches. How complex signaling information is integrated to specify these cell types remains a mystery. We find that modular expression of Forkhead domain transcription factors (Fox proteins) in the zebrafish face arises through integration of Hh, Fgf, Bmp, Edn1 and Jagged-Notch pathways. Whereas loss of C-class Fox proteins results in reduced upper facial cartilages, loss of F-class Fox proteins results in distal jaw truncations and absent midline cartilages and teeth. We show that Fox proteins are required for Sox9a to promote chondrogenic gene expression. Fox proteins are sufficient in neural crest-derived cells for cartilage development, and neural crest-specific misexpression of Fox proteins expands the cartilage domain but inhibits bone. These results support a modular role for Fox proteins in establishing the competency of progenitors to form cartilage and teeth in the face.
Keywords
MUTATION CONGENITAL-HYDROCEPHALUS, FORKHEAD/WINGED-HELIX GENE, TRANSCRIPTION FACTOR, CRANIOFACIAL SKELETON, GUT DEVELOPMENT, FIN, DEVELOPMENT, ESSENTIAL ROLES, NEURAL CREST, STEM-CELLS, ZEBRAFISH, Forkhead, Foxc1, Foxf1, Foxf2, Sox9, Cartilage, Teeth, Bone, Pharyngeal, arches, Craniofacial, Zebrafish

Citation

Please use this url to cite or link to this publication:

Chicago
Xu, Pengfei, Bartosz Balczerski, Amanda Ciozda, Kristin Louie, Veronika Oralova, Ann Huysseune, and J. Gage Crump. 2018. “Fox Proteins Are Modular Competency Factors for Facial Cartilage and Tooth Specification.” Development 145 (12).
APA
Xu, P., Balczerski, B., Ciozda, A., Louie, K., Oralova, V., Huysseune, A., & Crump, J. G. (2018). Fox proteins are modular competency factors for facial cartilage and tooth specification. DEVELOPMENT, 145(12).
Vancouver
1.
Xu P, Balczerski B, Ciozda A, Louie K, Oralova V, Huysseune A, et al. Fox proteins are modular competency factors for facial cartilage and tooth specification. DEVELOPMENT. Cambridge: Company Biologists Ltd; 2018;145(12).
MLA
Xu, Pengfei et al. “Fox Proteins Are Modular Competency Factors for Facial Cartilage and Tooth Specification.” DEVELOPMENT 145.12 (2018): n. pag. Print.
@article{8606203,
  abstract     = {Facial form depends on the precise positioning of cartilage, bone, and tooth fields in the embryonic pharyngeal arches. How complex signaling information is integrated to specify these cell types remains a mystery. We find that modular expression of Forkhead domain transcription factors (Fox proteins) in the zebrafish face arises through integration of Hh, Fgf, Bmp, Edn1 and Jagged-Notch pathways. Whereas loss of C-class Fox proteins results in reduced upper facial cartilages, loss of F-class Fox proteins results in distal jaw truncations and absent midline cartilages and teeth. We show that Fox proteins are required for Sox9a to promote chondrogenic gene expression. Fox proteins are sufficient in neural crest-derived cells for cartilage development, and neural crest-specific misexpression of Fox proteins expands the cartilage domain but inhibits bone. These results support a modular role for Fox proteins in establishing the competency of progenitors to form cartilage and teeth in the face.},
  articleno    = {UNSP dev165498},
  author       = {Xu, Pengfei and Balczerski, Bartosz and Ciozda, Amanda and Louie, Kristin and Oralova, Veronika and Huysseune, Ann and Crump, J. Gage},
  issn         = {0950-1991},
  journal      = {DEVELOPMENT},
  language     = {eng},
  number       = {12},
  pages        = {10},
  publisher    = {Company Biologists Ltd},
  title        = {Fox proteins are modular competency factors for facial cartilage and tooth specification},
  url          = {http://dx.doi.org/10.1242/dev.165498},
  volume       = {145},
  year         = {2018},
}

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