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Microglia in central nervous system inflammation and multiple sclerosis pathology

Sofie Voet (UGent) , Marco Prinz and Geert van Loo (UGent)
(2019) TRENDS IN MOLECULAR MEDICINE. 25(2). p.112-123
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Abstract
Microglia are the resident macrophages of the central nervous system (CNS). They have important physiological functions in maintaining tissue homeostasis but also contribute to CNS pathology. Microglia respond to changes in the microenvironment, and the resulting reactive phenotype can be very diverse, with both neuroinflammatory and neuroprotective properties, illustrating the plasticity of these cells. Recent progress in understanding the autoimmune neuroinflammatory disease multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis suggests major roles for microglia in the disease, which have drastically changed our view on the function of microglia in MS.
Keywords
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, MYELOID CELLS, CNS-RESIDENT, M2 MICROGLIA, MACROPHAGES, REVEALS, ACTIVATION, MONOCYTES, MODEL, FATE

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Citation

Please use this url to cite or link to this publication:

MLA
Voet, Sofie, Marco Prinz, and Geert van Loo. “Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology.” TRENDS IN MOLECULAR MEDICINE 25.2 (2019): 112–123. Print.
APA
Voet, Sofie, Prinz, M., & van Loo, G. (2019). Microglia in central nervous system inflammation and multiple sclerosis pathology. TRENDS IN MOLECULAR MEDICINE, 25(2), 112–123.
Chicago author-date
Voet, Sofie, Marco Prinz, and Geert van Loo. 2019. “Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology.” Trends in Molecular Medicine 25 (2): 112–123.
Chicago author-date (all authors)
Voet, Sofie, Marco Prinz, and Geert van Loo. 2019. “Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology.” Trends in Molecular Medicine 25 (2): 112–123.
Vancouver
1.
Voet S, Prinz M, van Loo G. Microglia in central nervous system inflammation and multiple sclerosis pathology. TRENDS IN MOLECULAR MEDICINE. 2019;25(2):112–23.
IEEE
[1]
S. Voet, M. Prinz, and G. van Loo, “Microglia in central nervous system inflammation and multiple sclerosis pathology,” TRENDS IN MOLECULAR MEDICINE, vol. 25, no. 2, pp. 112–123, 2019.
@article{8605824,
  abstract     = {Microglia are the resident macrophages of the central nervous system (CNS). They have important physiological functions in maintaining tissue homeostasis but also contribute to CNS pathology. Microglia respond to changes in the microenvironment, and the resulting reactive phenotype can be very diverse, with both neuroinflammatory and neuroprotective properties, illustrating the plasticity of these cells. Recent progress in understanding the autoimmune neuroinflammatory disease multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis suggests major roles for microglia in the disease, which have drastically changed our view on the function of microglia in MS.},
  author       = {Voet, Sofie and Prinz, Marco and van Loo, Geert},
  issn         = {1471-4914},
  journal      = {TRENDS IN MOLECULAR MEDICINE},
  keywords     = {EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS,MYELOID CELLS,CNS-RESIDENT,M2 MICROGLIA,MACROPHAGES,REVEALS,ACTIVATION,MONOCYTES,MODEL,FATE},
  language     = {eng},
  number       = {2},
  pages        = {112--123},
  title        = {Microglia in central nervous system inflammation and multiple sclerosis pathology},
  url          = {http://dx.doi.org/10.1016/j.molmed.2018.11.005},
  volume       = {25},
  year         = {2019},
}

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