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Potential therapeutic application of bacteriophages and phage-derived endolysins as alternative treatment of bovine mastitis

Niels Vander Elst (UGent) and Evelyne Meyer (UGent)
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Abstract
The increase in bacterial drug resistance causes major difficulties in the clinical treatment of a growing number of bacterial infections worldwide. Consequently, there is an urgent need to develop novel anti-bacterial agents to control these resistant pathogens and to complement the currently used antibiotics. Mastitis is the most prevalent disease impacting dairy cattle, and therefore one of the costliest diseases in the global dairy industry. The excessive use of curative as well as preventive antibiotics in this sector entails a real risk for the emergence of antimicrobial resistance. Moreover, these traditional antimicrobial agents are often ineffective and lead to residues in the milk, which can affect dairy product consumers. As an alternative therapeutic approach, bacteriophages and phage-encoded endolysins have been proposed and are currently (re)investigated as potential antibacterial agents against mastitis.
Keywords
Bovine mastitis, Bacteriophages, Bacteriophage-derived endolysins, Dairy agriculture, LACTATING DAIRY-CATTLE, STAPHYLOCOCCUS-AUREUS, ANTIMICROBIAL RESISTANCE, PATHOGENS, MILK, COWS

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Citation

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MLA
Vander Elst, Niels, and Evelyne Meyer. “Potential Therapeutic Application of Bacteriophages and Phage-derived Endolysins as Alternative Treatment of Bovine Mastitis.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 87.4 (2018): 181–187. Print.
APA
Vander Elst, N., & Meyer, E. (2018). Potential therapeutic application of bacteriophages and phage-derived endolysins as alternative treatment of bovine mastitis. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 87(4), 181–187.
Chicago author-date
Vander Elst, Niels, and Evelyne Meyer. 2018. “Potential Therapeutic Application of Bacteriophages and Phage-derived Endolysins as Alternative Treatment of Bovine Mastitis.” Vlaams Diergeneeskundig Tijdschrift 87 (4): 181–187.
Chicago author-date (all authors)
Vander Elst, Niels, and Evelyne Meyer. 2018. “Potential Therapeutic Application of Bacteriophages and Phage-derived Endolysins as Alternative Treatment of Bovine Mastitis.” Vlaams Diergeneeskundig Tijdschrift 87 (4): 181–187.
Vancouver
1.
Vander Elst N, Meyer E. Potential therapeutic application of bacteriophages and phage-derived endolysins as alternative treatment of bovine mastitis. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2018;87(4):181–7.
IEEE
[1]
N. Vander Elst and E. Meyer, “Potential therapeutic application of bacteriophages and phage-derived endolysins as alternative treatment of bovine mastitis,” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, vol. 87, no. 4, pp. 181–187, 2018.
@article{8605107,
  abstract     = {The  increase  in  bacterial  drug  resistance  causes  major  difficulties  in  the  clinical  treatment of  a  growing  number  of  bacterial  infections  worldwide.  Consequently,  there  is  an  urgent  need  to  develop  novel  anti-bacterial  agents  to  control  these  resistant  pathogens  and  to  complement  the currently used antibiotics. Mastitis is the most prevalent disease impacting dairy cattle, and therefore one of the costliest diseases in the global dairy industry. The excessive use of curative as well as preventive antibiotics in this sector entails a real risk for the emergence of antimicrobial resistance.  Moreover,  these  traditional  antimicrobial  agents  are  often  ineffective  and  lead  to  residues  in  the  milk,  which  can  affect  dairy  product  consumers.  As  an  alternative  therapeutic  approach, bacteriophages and phage-encoded endolysins have been proposed and are currently (re)investigated as potential antibacterial agents against mastitis.},
  author       = {Vander Elst, Niels and Meyer, Evelyne},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keywords     = {Bovine mastitis,Bacteriophages,Bacteriophage-derived endolysins,Dairy agriculture,LACTATING DAIRY-CATTLE,STAPHYLOCOCCUS-AUREUS,ANTIMICROBIAL RESISTANCE,PATHOGENS,MILK,COWS},
  language     = {eng},
  number       = {4},
  pages        = {181--187},
  title        = {Potential therapeutic application of bacteriophages and phage-derived endolysins as alternative treatment of bovine mastitis},
  volume       = {87},
  year         = {2018},
}

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