Advanced search
1 file | 689.92 KB Add to list

Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder : a pooled analysis of seven European birth cohort studies

Author
Organization
Abstract
Background: Attention-deficit/hyperactivity disorder (ADHD) is increasing worldwide for reasons largely unknown and environmental chemicals with neurotoxic properties, such as persistent organic pollutants (POPs), have been proposed to play a role. We investigated the association between prenatal and postnatal exposure to polychlorinated biphenyl-153 (PCB-153), p-p'-dichlorodiphenyldichloroethylene (p-p'-DDE) and hexachlorobenzene (HCB) and ADHD in childhood. Methods: We pooled seven European birth cohort studies encompassing 4437 motherchild pairs from the general population with concentrations of PCB-153, p-p'-DDE and HCB measured in cord blood, maternal blood or milk. We then calculated prenatal (birth) and postnatal (3, 6, 12 and 24 months) POP concentrations using a pharmacokinetic model. The operational definition of ADHD varied across cohorts and ranged from doctor diagnosis obtained from patient registries to maternal or teachers reports. We used multilevel (mixed) logistic regression models to estimate the associations between exposure to POPs at birth, 3, 6, 12 and 24 months and ADHD. Results: The global prevalence of ADHD in our study was 6%. The mean age at assessment of ADHD was 5.8 years (range: 3.8-9.5 years). We found no association between exposure to PCB-153, p-p'-DDE and HCB at any age point between birth and 24 months and ADHD, in the pooled analyses (pooled odds ratios ranging from 1.00 to 1.01). A number of sensitivity analyses gave basically the same results. Conclusions: In the largest study to date of 4437 children in seven European birth cohorts, we did not observe any association between either pre- or postnatal exposure (up to 24 months) to PCB-153, p-p'-DDE and HCB and the risk of ADHD before the age of 10 years.
Keywords
DDT, hexachlorobenzene, polychlorinated biphenyls, attention-deficit disorder with hyperactivity, POLYCHLORINATED-BIPHENYLS PCBS, SCHOOL-AGED CHILDREN, INFANT GROWTH, DEFICIT/HYPERACTIVITY DISORDER, DEVELOPMENTAL NEUROTOXICITY, ORGANOCHLORINE EXPOSURE, 8-YEAR-OLD CHILDREN, PERINATAL EXPOSURE, HEXACHLOROBENZENE, ADHD

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 689.92 KB

Citation

Please use this url to cite or link to this publication:

MLA
Forns, Joan et al. “Prenatal and Postnatal Exposure to Persistent Organic Pollutants and Attention-deficit and Hyperactivity Disorder : a Pooled Analysis of Seven European Birth Cohort Studies.” INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 47.4 (2018): 1082–1097. Print.
APA
Forns, J., Stigum, H., Høyer, B. B., Sioen, I., Sovcikova, E., Nowack, N., Lopez-Espinosa, M.-J., et al. (2018). Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder : a pooled analysis of seven European birth cohort studies. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 47(4), 1082–1097.
Chicago author-date
Forns, Joan, Hein Stigum, Birgit Bjerre Høyer, Isabelle Sioen, Eva Sovcikova, Nikola Nowack, Maria-Jose Lopez-Espinosa, et al. 2018. “Prenatal and Postnatal Exposure to Persistent Organic Pollutants and Attention-deficit and Hyperactivity Disorder : a Pooled Analysis of Seven European Birth Cohort Studies.” International Journal of Epidemiology 47 (4): 1082–1097.
Chicago author-date (all authors)
Forns, Joan, Hein Stigum, Birgit Bjerre Høyer, Isabelle Sioen, Eva Sovcikova, Nikola Nowack, Maria-Jose Lopez-Espinosa, Mònica Guxens, Jesús Ibarluzea, Matias Torrent, Jürgen Wittsiepe, Eva Govarts, Tomas Trnovec, Cecile Chevrier, Gunnar Toft, Martine Vrijheid, Nina Iszatt, and Merete Eggesbø. 2018. “Prenatal and Postnatal Exposure to Persistent Organic Pollutants and Attention-deficit and Hyperactivity Disorder : a Pooled Analysis of Seven European Birth Cohort Studies.” International Journal of Epidemiology 47 (4): 1082–1097.
Vancouver
1.
Forns J, Stigum H, Høyer BB, Sioen I, Sovcikova E, Nowack N, et al. Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder : a pooled analysis of seven European birth cohort studies. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2018;47(4):1082–97.
IEEE
[1]
J. Forns et al., “Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder : a pooled analysis of seven European birth cohort studies,” INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, vol. 47, no. 4, pp. 1082–1097, 2018.
@article{8605059,
  abstract     = {Background: Attention-deficit/hyperactivity disorder (ADHD) is increasing worldwide for reasons largely unknown and environmental chemicals with neurotoxic properties, such as persistent organic pollutants (POPs), have been proposed to play a role. We investigated the association between prenatal and postnatal exposure to polychlorinated biphenyl-153 (PCB-153), p-p'-dichlorodiphenyldichloroethylene (p-p'-DDE) and hexachlorobenzene (HCB) and ADHD in childhood. 
Methods: We pooled seven European birth cohort studies encompassing 4437 motherchild pairs from the general population with concentrations of PCB-153, p-p'-DDE and HCB measured in cord blood, maternal blood or milk. We then calculated prenatal (birth) and postnatal (3, 6, 12 and 24 months) POP concentrations using a pharmacokinetic model. The operational definition of ADHD varied across cohorts and ranged from doctor diagnosis obtained from patient registries to maternal or teachers reports. We used multilevel (mixed) logistic regression models to estimate the associations between exposure to POPs at birth, 3, 6, 12 and 24 months and ADHD. 
Results: The global prevalence of ADHD in our study was 6%. The mean age at assessment of ADHD was 5.8 years (range: 3.8-9.5 years). We found no association between exposure to PCB-153, p-p'-DDE and HCB at any age point between birth and 24 months and ADHD, in the pooled analyses (pooled odds ratios ranging from 1.00 to 1.01). A number of sensitivity analyses gave basically the same results. 
Conclusions: In the largest study to date of 4437 children in seven European birth cohorts, we did not observe any association between either pre- or postnatal exposure (up to 24 months) to PCB-153, p-p'-DDE and HCB and the risk of ADHD before the age of 10 years.},
  author       = {Forns, Joan and Stigum, Hein and Høyer, Birgit Bjerre and Sioen, Isabelle and Sovcikova, Eva and Nowack, Nikola and Lopez-Espinosa, Maria-Jose and Guxens, Mònica and Ibarluzea, Jesús and Torrent, Matias and Wittsiepe, Jürgen and Govarts, Eva and Trnovec, Tomas and Chevrier, Cecile and Toft, Gunnar and Vrijheid, Martine and Iszatt, Nina and Eggesbø, Merete},
  issn         = {0300-5771},
  journal      = {INTERNATIONAL JOURNAL OF EPIDEMIOLOGY},
  keywords     = {DDT,hexachlorobenzene,polychlorinated biphenyls,attention-deficit disorder with hyperactivity,POLYCHLORINATED-BIPHENYLS PCBS,SCHOOL-AGED CHILDREN,INFANT GROWTH,DEFICIT/HYPERACTIVITY DISORDER,DEVELOPMENTAL NEUROTOXICITY,ORGANOCHLORINE EXPOSURE,8-YEAR-OLD CHILDREN,PERINATAL EXPOSURE,HEXACHLOROBENZENE,ADHD},
  language     = {eng},
  number       = {4},
  pages        = {1082--1097},
  title        = {Prenatal and postnatal exposure to persistent organic pollutants and attention-deficit and hyperactivity disorder : a pooled analysis of seven European birth cohort studies},
  url          = {http://dx.doi.org/10.1093/ije/dyy052},
  volume       = {47},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: