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Is the hematocrit still an issue in quantitative dried blood spot analysis?

Sofie Velghe (UGent) , Lisa Delahaye (UGent) and Christophe Stove (UGent)
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Abstract
Hematocrit-related issues remain a major barrier for (regulatory) acceptance of the classical dried blood spot (DBS) analysis in the bioanalytical and clinical field. Lately, many attempts to cope with these issues have been made. Throughout this review, an overview is provided on new strategies that try to cope with this hematocrit effect (going from avoiding to minimizing), on methods estimating a DBS volume, and on methods estimating or measuring the hematocrit of a DBS. Although many successful strategies have been put forward, a combination of different technologies still provides the most complete solution. Therefore, further efforts and the availability of a straightforward guideline for analytical and clinical method validation should help to overcome the hurdles still associated with DBS sampling. (C) 2018 Elsevier B.V. All rights reserved.
Keywords
ALTERNATIVE SAMPLING STRATEGIES, PLASMA SPOTS, POTASSIUM MEASUREMENT, INDEPENDENT RECOVERY, INTERNAL STANDARD, LC-MS/MS, DEVICE, DBS, EXTRACTION, VALIDATION, Hematocrit, Dried blood spot, Alternative sampling

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Citation

Please use this url to cite or link to this publication:

Chicago
Velghe, Sofie, Lisa Delahaye, and Christophe Stove. 2019. “Is the Hematocrit Still an Issue in Quantitative Dried Blood Spot Analysis?” Journal of Pharmaceutical and Biomedical Analysis 163: 188–196.
APA
Velghe, S., Delahaye, L., & Stove, C. (2019). Is the hematocrit still an issue in quantitative dried blood spot analysis? JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 163, 188–196.
Vancouver
1.
Velghe S, Delahaye L, Stove C. Is the hematocrit still an issue in quantitative dried blood spot analysis? JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. Amsterdam: Elsevier Science Bv; 2019;163:188–96.
MLA
Velghe, Sofie, Lisa Delahaye, and Christophe Stove. “Is the Hematocrit Still an Issue in Quantitative Dried Blood Spot Analysis?” JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 163 (2019): 188–196. Print.
@article{8604875,
  abstract     = {Hematocrit-related issues remain a major barrier for (regulatory) acceptance of the classical dried blood spot (DBS) analysis in the bioanalytical and clinical field. Lately, many attempts to cope with these issues have been made. Throughout this review, an overview is provided on new strategies that try to cope with this hematocrit effect (going from avoiding to minimizing), on methods estimating a DBS volume, and on methods estimating or measuring the hematocrit of a DBS. Although many successful strategies have been put forward, a combination of different technologies still provides the most complete solution. Therefore, further efforts and the availability of a straightforward guideline for analytical and clinical method validation should help to overcome the hurdles still associated with DBS sampling. (C) 2018 Elsevier B.V. All rights reserved.},
  author       = {Velghe, Sofie and Delahaye, Lisa and Stove, Christophe},
  issn         = {0731-7085},
  journal      = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS},
  language     = {eng},
  pages        = {188--196},
  publisher    = {Elsevier Science Bv},
  title        = {Is the hematocrit still an issue in quantitative dried blood spot analysis?},
  url          = {http://dx.doi.org/10.1016/j.jpba.2018.10.010},
  volume       = {163},
  year         = {2019},
}

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