Advanced search
1 file | 359.84 KB Add to list

The association between dietary protein intake, energy intake and physical frailty : results from the Rotterdam Study

(2019) BRITISH JOURNAL OF NUTRITION. 121(4). p.393-401
Author
Organization
Abstract
Sufficient protein intake has been suggested to be important for preventing physical frailty, but studies show conflicting results which may be explained because not all studies address protein source and intake of other macronutrients and total energy. Therefore, we studied 2504 subjects with data on diet and physical frailty, participating in a large population-based prospective cohort among subjects aged 45+ years (the Rotterdam Study). Dietary intake was assessed with a FFQ. Frailty was defined according to the frailty phenotype as the presence of at least three out of the following five symptoms: weight loss, low physical activity, weakness, slowness and fatigue. We used multinomial logistic regression models to evaluate the independent association between protein intake and frailty using two methods: nutrient residual models and energy decomposition models. With every increase in 10 g total, plant or animal protein per d, the odds to be frail were 1·06 (95 % CI 0·98, 1·15), 0·87 (95 % CI 0·71, 1·07) and 1·07 (95 % CI 0·99, 1·15), respectively, using the nutrient residual method. Using the energy partition model, we observed that the odds to be frail were lower with higher vegetable protein intake (OR per 418·4 kJ (100 kcal): 0·61, 95 % CI 0·39, 0·97), however, results disappeared when adjusting for physical activity. For energy intake from any source we observed that with every 418·4 kJ (100 kcal) increase, the odds to be frail were 5 % lower (OR: 0·95, 95 % CI 0·93, 0·97). Our results suggest that energy intake, but not protein specifically, is associated with less frailty. Considering other macronutrients, physical activity and diet quality seems to be essential for future studies on protein and frailty.
Keywords
Physical frailty, Protein intake, Protein source, Energy adjustment, Population-based studies, NUTRIENT INTAKE, OLDER PERSONS, AMINO-ACIDS, MUSCLE, QUALITY, RISK, SUPPLEMENTATION, METAANALYSIS, NUTRITION, MORTALITY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 359.84 KB

Citation

Please use this url to cite or link to this publication:

MLA
Schoufour, Josje D., et al. “The Association between Dietary Protein Intake, Energy Intake and Physical Frailty : Results from the Rotterdam Study.” BRITISH JOURNAL OF NUTRITION, vol. 121, no. 4, 2019, pp. 393–401.
APA
Schoufour, J. D., Franco, O. H., Kiefte-de Jong, J. C., Trajanoska, K., Stricker, B., Brusselle, G., … Voortman, T. (2019). The association between dietary protein intake, energy intake and physical frailty : results from the Rotterdam Study. BRITISH JOURNAL OF NUTRITION, 121(4), 393–401.
Chicago author-date
Schoufour, Josje D, Oscar H Franco, Jessica C Kiefte-de Jong, Katerina Trajanoska, Bruno Stricker, Guy Brusselle, Fernando Rivadeneira, Lies Lahousse, and Trudy Voortman. 2019. “The Association between Dietary Protein Intake, Energy Intake and Physical Frailty : Results from the Rotterdam Study.” BRITISH JOURNAL OF NUTRITION 121 (4): 393–401.
Chicago author-date (all authors)
Schoufour, Josje D, Oscar H Franco, Jessica C Kiefte-de Jong, Katerina Trajanoska, Bruno Stricker, Guy Brusselle, Fernando Rivadeneira, Lies Lahousse, and Trudy Voortman. 2019. “The Association between Dietary Protein Intake, Energy Intake and Physical Frailty : Results from the Rotterdam Study.” BRITISH JOURNAL OF NUTRITION 121 (4): 393–401.
Vancouver
1.
Schoufour JD, Franco OH, Kiefte-de Jong JC, Trajanoska K, Stricker B, Brusselle G, et al. The association between dietary protein intake, energy intake and physical frailty : results from the Rotterdam Study. BRITISH JOURNAL OF NUTRITION. 2019;121(4):393–401.
IEEE
[1]
J. D. Schoufour et al., “The association between dietary protein intake, energy intake and physical frailty : results from the Rotterdam Study,” BRITISH JOURNAL OF NUTRITION, vol. 121, no. 4, pp. 393–401, 2019.
@article{8604646,
  abstract     = {Sufficient protein intake has been suggested to be important for preventing physical frailty, but studies show conflicting results which may be explained because not all studies address protein source and intake of other macronutrients and total energy. Therefore, we studied 2504 subjects with data on diet and physical frailty, participating in a large population-based prospective cohort among subjects aged 45+ years (the Rotterdam Study). Dietary intake was assessed with a FFQ. Frailty was defined according to the frailty phenotype as the presence of at least three out of the following five symptoms: weight loss, low physical activity, weakness, slowness and fatigue. We used multinomial logistic regression models to evaluate the independent association between protein intake and frailty using two methods: nutrient residual models and energy decomposition models. With every increase in 10 g total, plant or animal protein per d, the odds to be frail were 1·06 (95 % CI 0·98, 1·15), 0·87 (95 % CI 0·71, 1·07) and 1·07 (95 % CI 0·99, 1·15), respectively, using the nutrient residual method. Using the energy partition model, we observed that the odds to be frail were lower with higher vegetable protein intake (OR per 418·4 kJ (100 kcal): 0·61, 95 % CI 0·39, 0·97), however, results disappeared when adjusting for physical activity. For energy intake from any source we observed that with every 418·4 kJ (100 kcal) increase, the odds to be frail were 5 % lower (OR: 0·95, 95 % CI 0·93, 0·97). Our results suggest that energy intake, but not protein specifically, is associated with less frailty. Considering other macronutrients, physical activity and diet quality seems to be essential for future studies on protein and frailty.},
  author       = {Schoufour, Josje D and Franco, Oscar H and Kiefte-de Jong, Jessica C and Trajanoska, Katerina and Stricker, Bruno and Brusselle, Guy and Rivadeneira, Fernando and Lahousse, Lies and Voortman, Trudy},
  issn         = {0007-1145},
  journal      = {BRITISH JOURNAL OF NUTRITION},
  keywords     = {Physical frailty,Protein intake,Protein source,Energy adjustment,Population-based studies,NUTRIENT INTAKE,OLDER PERSONS,AMINO-ACIDS,MUSCLE,QUALITY,RISK,SUPPLEMENTATION,METAANALYSIS,NUTRITION,MORTALITY},
  language     = {eng},
  number       = {4},
  pages        = {393--401},
  title        = {The association between dietary protein intake, energy intake and physical frailty : results from the Rotterdam Study},
  url          = {http://dx.doi.org/10.1017/s0007114518003367},
  volume       = {121},
  year         = {2019},
}

Altmetric
View in Altmetric
Web of Science
Times cited: