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Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation

(2019) MUCOSAL IMMUNOLOGY. 12(2). p.340-351
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Abstract
Chronic obstructive pulmonary disease (COPD) is associated with abnormal inflammatory responses and airway wall remodeling, leading to reduced lung function. An association between the bone morphogenetic protein (BMP-6) locus and forced vital capacity has been found in a genome-wide association study. However, the role of BMP-6 in the pathogenesis of COPD remains unknown. The pulmonary expression of BMP-6 was analyzed in patients with COPD and in cigarette smoke (CS)-exposed mice. We evaluated lung function and histology in BMP-6 KO mice at baseline. We exposed BMP-6 KO mice to CS for 4 weeks and measured pulmonary inflammation and iron levels. Pulmonary mRNA levels of BMP-6 were decreased in smokers with and without COPD and in CS-exposed mice. Importantly, BMP-6 expression was lowest in severe COPD. Accordingly, protein levels of BMP-6 were decreased in patients with COPD. Lung function measurements demonstrated a decreased compliance and total lung capacity in BMP-6 KO mice, whereas lung histology was normal. Furthermore, BMP-6 KO mice displayed elevated iron levels and an aggravated CS-induced inflammatory response. These results suggest that BMP-6 is important for normal lung function and that downregulation of BMP-6-as observed in patients with COPD-contributes to pulmonary inflammation after CS exposure.
Keywords
GENOME-WIDE ASSOCIATION, GENE-EXPRESSION, ACTIVATION, CHEMOKINE, CELLS

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MLA
Verhamme, Fien et al. “Bone Morphogenetic Protein 6 (BMP-6) Modulates Lung Function, Pulmonary Iron Levels and Cigarette Smoke-induced Inflammation.” MUCOSAL IMMUNOLOGY 12.2 (2019): 340–351. Print.
APA
Verhamme, F., De Smet, E., Van Hooste, W., Delanghe, J., Verleden, S., Joos, G., Brusselle, G., et al. (2019). Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation. MUCOSAL IMMUNOLOGY, 12(2), 340–351.
Chicago author-date
Verhamme, Fien, Elise De Smet, Wannes Van Hooste, Joris Delanghe, SE Verleden, Guy Joos, Guy Brusselle, and Ken Bracke. 2019. “Bone Morphogenetic Protein 6 (BMP-6) Modulates Lung Function, Pulmonary Iron Levels and Cigarette Smoke-induced Inflammation.” Mucosal Immunology 12 (2): 340–351.
Chicago author-date (all authors)
Verhamme, Fien, Elise De Smet, Wannes Van Hooste, Joris Delanghe, SE Verleden, Guy Joos, Guy Brusselle, and Ken Bracke. 2019. “Bone Morphogenetic Protein 6 (BMP-6) Modulates Lung Function, Pulmonary Iron Levels and Cigarette Smoke-induced Inflammation.” Mucosal Immunology 12 (2): 340–351.
Vancouver
1.
Verhamme F, De Smet E, Van Hooste W, Delanghe J, Verleden S, Joos G, et al. Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation. MUCOSAL IMMUNOLOGY. 2019;12(2):340–51.
IEEE
[1]
F. Verhamme et al., “Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation,” MUCOSAL IMMUNOLOGY, vol. 12, no. 2, pp. 340–351, 2019.
@article{8604641,
  abstract     = {Chronic obstructive pulmonary disease (COPD) is associated with abnormal inflammatory responses and airway wall remodeling, leading to reduced lung function. An association between the bone morphogenetic protein (BMP-6) locus and forced vital capacity has been found in a genome-wide association study. However, the role of BMP-6 in the pathogenesis of COPD remains unknown. The pulmonary expression of BMP-6 was analyzed in patients with COPD and in cigarette smoke (CS)-exposed mice. We evaluated lung function and histology in BMP-6 KO mice at baseline. We exposed BMP-6 KO mice to CS for 4 weeks and measured pulmonary inflammation and iron levels. Pulmonary mRNA levels of BMP-6 were decreased in smokers with and without COPD and in CS-exposed mice. Importantly, BMP-6 expression was lowest in severe COPD. Accordingly, protein levels of BMP-6 were decreased in patients with COPD. Lung function measurements demonstrated a decreased compliance and total lung capacity in BMP-6 KO mice, whereas lung histology was normal. Furthermore, BMP-6 KO mice displayed elevated iron levels and an aggravated CS-induced inflammatory response. These results suggest that BMP-6 is important for normal lung function and that downregulation of BMP-6-as observed in patients with COPD-contributes to pulmonary inflammation after CS exposure.},
  author       = {Verhamme, Fien and De Smet, Elise and Van Hooste, Wannes and Delanghe, Joris and Verleden, SE and Joos, Guy and Brusselle, Guy and Bracke, Ken},
  issn         = {1933-0219},
  journal      = {MUCOSAL IMMUNOLOGY},
  keywords     = {GENOME-WIDE ASSOCIATION,GENE-EXPRESSION,ACTIVATION,CHEMOKINE,CELLS},
  language     = {eng},
  number       = {2},
  pages        = {340--351},
  title        = {Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation},
  url          = {http://dx.doi.org/10.1038/s41385-018-0116-2},
  volume       = {12},
  year         = {2019},
}

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