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Micropatterning of beta tricalcium phosphate bioceramic surfaces, by femtosecond laser, for bone marrow stem cells behavior assessment

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Abstract
The bioactivity of synthetic bone implants is highly impacted by their surface topography, especially by the presence of micro-patterns likely to generate cells growth guidance. In this study, laser machining (ethnology was employed in order to produce controlled regular micro-patterns on dense calcium phosphate surfaces, without any contamination. The choice of the source was directed towards a femtosecond pulsed laser in order to limit the thermal impact of such a process and thus to avoid the unwanted phase transformations potentially induced by the temperature elevation. Beta tricalcium phosphate substrates with perfectly controlled micro-patterning and without any secondary phase were obtained by optimization of the process parameters (laser power, scanning speed, pulse frequency). The microstructural characteristics were investigated by microscopy (optical, confocal, scanning electron) and the phase identification was performed by X-ray diffraction. This work allowed highlighting the effects of the process parameters on the patterning. The high benefits of the laser treatment on wettability were shown by contact angle assays. Finally, the influence of surface micro-patterning on cell behavior was highlighted in vitro. This technique seems to provide an interesting alternative to conventional surface treatments of calcium phosphates.
Keywords
NITI ALLOY, HYDROXYAPATITE, MICROSTRUCTURES, COLONIZATION, CERAMICS, GEOMETRY, ADHESION, APATITES

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MLA
Lasgorceix, Marie et al. “Micropatterning of Beta Tricalcium Phosphate Bioceramic Surfaces, by Femtosecond Laser, for Bone Marrow Stem Cells Behavior Assessment.” MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 95 (2019): 371–380. Print.
APA
Lasgorceix, M., Ott, C., Boilet, L., Hocquet, S., Leriche, A., Asadian, M., De Geyter, N., et al. (2019). Micropatterning of beta tricalcium phosphate bioceramic surfaces, by femtosecond laser, for bone marrow stem cells behavior assessment. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 95, 371–380.
Chicago author-date
Lasgorceix, Marie, Cedric Ott, Laurent Boilet, Stephane Hocquet, Anne Leriche, Mahtab Asadian, Nathalie De Geyter, Heidi Declercq, Veronique Lardot, and Francis Cambier. 2019. “Micropatterning of Beta Tricalcium Phosphate Bioceramic Surfaces, by Femtosecond Laser, for Bone Marrow Stem Cells Behavior Assessment.” Materials Science & Engineering C-materials for Biological Applications 95: 371–380.
Chicago author-date (all authors)
Lasgorceix, Marie, Cedric Ott, Laurent Boilet, Stephane Hocquet, Anne Leriche, Mahtab Asadian, Nathalie De Geyter, Heidi Declercq, Veronique Lardot, and Francis Cambier. 2019. “Micropatterning of Beta Tricalcium Phosphate Bioceramic Surfaces, by Femtosecond Laser, for Bone Marrow Stem Cells Behavior Assessment.” Materials Science & Engineering C-materials for Biological Applications 95: 371–380.
Vancouver
1.
Lasgorceix M, Ott C, Boilet L, Hocquet S, Leriche A, Asadian M, et al. Micropatterning of beta tricalcium phosphate bioceramic surfaces, by femtosecond laser, for bone marrow stem cells behavior assessment. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 2019;95:371–80.
IEEE
[1]
M. Lasgorceix et al., “Micropatterning of beta tricalcium phosphate bioceramic surfaces, by femtosecond laser, for bone marrow stem cells behavior assessment,” MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, vol. 95, pp. 371–380, 2019.
@article{8604403,
  abstract     = {The bioactivity of synthetic bone implants is highly impacted by their surface topography, especially by the presence of micro-patterns likely to generate cells growth guidance. In this study, laser machining (ethnology was employed in order to produce controlled regular micro-patterns on dense calcium phosphate surfaces, without any contamination. The choice of the source was directed towards a femtosecond pulsed laser in order to limit the thermal impact of such a process and thus to avoid the unwanted phase transformations potentially induced by the temperature elevation. Beta tricalcium phosphate substrates with perfectly controlled micro-patterning and without any secondary phase were obtained by optimization of the process parameters (laser power, scanning speed, pulse frequency). The microstructural characteristics were investigated by microscopy (optical, confocal, scanning electron) and the phase identification was performed by X-ray diffraction. This work allowed highlighting the effects of the process parameters on the patterning. The high benefits of the laser treatment on wettability were shown by contact angle assays. Finally, the influence of surface micro-patterning on cell behavior was highlighted in vitro. This technique seems to provide an interesting alternative to conventional surface treatments of calcium phosphates.},
  author       = {Lasgorceix, Marie and Ott, Cedric and Boilet, Laurent and Hocquet, Stephane and Leriche, Anne and Asadian, Mahtab and De Geyter, Nathalie and Declercq, Heidi and Lardot, Veronique and Cambier, Francis},
  issn         = {0928-4931},
  journal      = {MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS},
  keywords     = {NITI ALLOY,HYDROXYAPATITE,MICROSTRUCTURES,COLONIZATION,CERAMICS,GEOMETRY,ADHESION,APATITES},
  language     = {eng},
  pages        = {371--380},
  title        = {Micropatterning of beta tricalcium phosphate bioceramic surfaces, by femtosecond laser, for bone marrow stem cells behavior assessment},
  url          = {http://dx.doi.org/10.1016/j.msec.2018.03.004},
  volume       = {95},
  year         = {2019},
}

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