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Dopamine transporter SPECT using fast kinetic ligands : 123I-FP-β-CIT versus 99mTc-TRODAT-1

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Organization
Abstract
A comparative study was carried out on two promising presynaptic dopamine transporter single-photon emission tomography (SPECT) radioligands with a fast pharmacokinetic profile, I-123-FP-beta-CIT (FP) and Tc-99m-TRODAT-1 (TR), in order to assess their differential diagnostic power in early parkinsonism and their sensitivity for detection of disease progression. This cross-sectional study was conducted on 96 patients with early-stage parkinsonism referred in a tertiary clinical setting. Mean disease duration was 2.0 +/- 1.3 years, and patients had a modified Hoehn and Yahr (H&Y) stage of 1-2 (average 1.2). Forty-seven patients received TR, and 49 received FP. In both groups, ten patients with normal presynaptic function were included as a control population; all other patients were clinically diagnosed as having idiopathic Parkinson's disease. Groups were matched for gender, age, disease duration and modified H&Y stage. Triple-head gamma camera SPECT was analysed using a serniquantitative index of transporter binding (BI). Discriminant analysis with cross-validation resulted in a maximal classification accuracy for FP of 93% (sensitivity 95% and specificity 86%) for the contralateral putamen BI. For TR, the corresponding values were 87% accuracy, 92% sensitivity and 70% specificity. For FP, disease duration was correlated with both the putamen BI (-8.8%/year, rho=-0.41, P=0.025) and the putamen/caudate ratio (-7.4%/year, rho=-0.51, P=0.004), but for TR no significant correlation was found (all P values >0.5). In conclusion, both FP and TR show high sensitivity in a clinically relevant setting, but FP has superior accuracy for early differential diagnosis of idiopathic parkinsonism and non-degenerative extrapyran-tidal disorders, as well as better sensitivity for disease follow-up.
Keywords
FP-beta-CIT, TRODAT-1, idiopathic parkinsonism, Parkinson's disease, differential diagnosis, STAGE PARKINSONS-DISEASE, MULTIPLE SYSTEM ATROPHY, IMAGING AGENT, BETA-CIT, PROGRESSION, BRAIN, PET, DEGENERATION, DIAGNOSIS, NEUROTRANSMISSION

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MLA
Van Laere, K et al. “Dopamine Transporter SPECT Using Fast Kinetic Ligands : 123I-FP-β-CIT Versus 99mTc-TRODAT-1.” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 31.8 (2004): 1119–1127. Print.
APA
Van Laere, K, De Ceuninck, L., Dom, R., Van den Eynden, J., Vanbilloen, H., Cleynhens, J., Dupont, P., et al. (2004). Dopamine transporter SPECT using fast kinetic ligands : 123I-FP-β-CIT versus 99mTc-TRODAT-1. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 31(8), 1119–1127.
Chicago author-date
Van Laere, K, L De Ceuninck, R Dom, Jimmy Van den Eynden, H Vanbilloen, J Cleynhens, P Dupont, G Bormans, A Verbruggen, and L Mortelmans. 2004. “Dopamine Transporter SPECT Using Fast Kinetic Ligands : 123I-FP-β-CIT Versus 99mTc-TRODAT-1.” European Journal of Nuclear Medicine and Molecular Imaging 31 (8): 1119–1127.
Chicago author-date (all authors)
Van Laere, K, L De Ceuninck, R Dom, Jimmy Van den Eynden, H Vanbilloen, J Cleynhens, P Dupont, G Bormans, A Verbruggen, and L Mortelmans. 2004. “Dopamine Transporter SPECT Using Fast Kinetic Ligands : 123I-FP-β-CIT Versus 99mTc-TRODAT-1.” European Journal of Nuclear Medicine and Molecular Imaging 31 (8): 1119–1127.
Vancouver
1.
Van Laere K, De Ceuninck L, Dom R, Van den Eynden J, Vanbilloen H, Cleynhens J, et al. Dopamine transporter SPECT using fast kinetic ligands : 123I-FP-β-CIT versus 99mTc-TRODAT-1. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2004;31(8):1119–27.
IEEE
[1]
K. Van Laere et al., “Dopamine transporter SPECT using fast kinetic ligands : 123I-FP-β-CIT versus 99mTc-TRODAT-1,” EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 31, no. 8, pp. 1119–1127, 2004.
@article{8604322,
  abstract     = {A comparative study was carried out on two promising presynaptic dopamine transporter single-photon emission tomography (SPECT) radioligands with a fast pharmacokinetic profile, I-123-FP-beta-CIT (FP) and Tc-99m-TRODAT-1 (TR), in order to assess their differential diagnostic power in early parkinsonism and their sensitivity for detection of disease progression. This cross-sectional study was conducted on 96 patients with early-stage parkinsonism referred in a tertiary clinical setting. Mean disease duration was 2.0 +/- 1.3 years, and patients had a modified Hoehn and Yahr (H&Y) stage of 1-2 (average 1.2). Forty-seven patients received TR, and 49 received FP. In both groups, ten patients with normal presynaptic function were included as a control population; all other patients were clinically diagnosed as having idiopathic Parkinson's disease. Groups were matched for gender, age, disease duration and modified H&Y stage. Triple-head gamma camera SPECT was analysed using a serniquantitative index of transporter binding (BI). Discriminant analysis with cross-validation resulted in a maximal classification accuracy for FP of 93% (sensitivity 95% and specificity 86%) for the contralateral putamen BI. For TR, the corresponding values were 87% accuracy, 92% sensitivity and 70% specificity. For FP, disease duration was correlated with both the putamen BI (-8.8%/year, rho=-0.41, P=0.025) and the putamen/caudate ratio (-7.4%/year, rho=-0.51, P=0.004), but for TR no significant correlation was found (all P values >0.5). In conclusion, both FP and TR show high sensitivity in a clinically relevant setting, but FP has superior accuracy for early differential diagnosis of idiopathic parkinsonism and non-degenerative extrapyran-tidal disorders, as well as better sensitivity for disease follow-up.},
  author       = {Van Laere, K and De Ceuninck, L and Dom, R and Van den Eynden, Jimmy and Vanbilloen, H and Cleynhens, J and Dupont, P and Bormans, G and Verbruggen, A and Mortelmans, L},
  issn         = {1619-7070},
  journal      = {EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},
  keywords     = {FP-beta-CIT,TRODAT-1,idiopathic parkinsonism,Parkinson's disease,differential diagnosis,STAGE PARKINSONS-DISEASE,MULTIPLE SYSTEM ATROPHY,IMAGING AGENT,BETA-CIT,PROGRESSION,BRAIN,PET,DEGENERATION,DIAGNOSIS,NEUROTRANSMISSION},
  language     = {eng},
  number       = {8},
  pages        = {1119--1127},
  title        = {Dopamine transporter SPECT using fast kinetic ligands : 123I-FP-β-CIT versus 99mTc-TRODAT-1},
  url          = {http://dx.doi.org/10.1007/s00259-004-1480-6},
  volume       = {31},
  year         = {2004},
}

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