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Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors

(2019) ELIFE. 8.
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Abstract
Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.
Keywords
General Biochemistry, Genetics and Molecular Biology, General Immunology and Microbiology, General Neuroscience, General Medicine

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Chicago
Shapiguzov, Alexey, Julia P Vainonen, Kerri Hunter, Helena Tossavainen, Arjun Tiwari, Sari Järvi, Maarit Hellman, et al. 2019. “Arabidopsis RCD1 Coordinates Chloroplast and Mitochondrial Functions Through Interaction with ANAC Transcription Factors.” Elife 8.
APA
Shapiguzov, A., Vainonen, J. P., Hunter, K., Tossavainen, H., Tiwari, A., Järvi, S., Hellman, M., et al. (2019). Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors. ELIFE, 8.
Vancouver
1.
Shapiguzov A, Vainonen JP, Hunter K, Tossavainen H, Tiwari A, Järvi S, et al. Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors. ELIFE. 2019;8.
MLA
Shapiguzov, Alexey et al. “Arabidopsis RCD1 Coordinates Chloroplast and Mitochondrial Functions Through Interaction with ANAC Transcription Factors.” ELIFE 8 (2019): n. pag. Print.
@article{8603621,
  abstract     = {Reactive oxygen species (ROS)-dependent signaling pathways from chloroplasts and mitochondria merge at the nuclear protein RADICAL-INDUCED CELL DEATH1 (RCD1). RCD1 interacts in vivo and suppresses the activity of the transcription factors ANAC013 and ANAC017, which mediate a ROS-related retrograde signal originating from mitochondrial complex III. Inactivation of RCD1 leads to increased expression of mitochondrial dysfunction stimulon (MDS) genes regulated by ANAC013 and ANAC017. Accumulating MDS gene products, including alternative oxidases (AOXs), affect redox status of the chloroplasts, leading to changes in chloroplast ROS processing and increased protection of photosynthetic apparatus. ROS alter the abundance, thiol redox state and oligomerization of the RCD1 protein in vivo, providing feedback control on its function. RCD1-dependent regulation is linked to chloroplast signaling by 3'-phosphoadenosine 5'-phosphate (PAP). Thus, RCD1 integrates organellar signaling from chloroplasts and mitochondria to establish transcriptional control over the metabolic processes in both organelles.},
  articleno    = {e43284},
  author       = {Shapiguzov, Alexey and Vainonen, Julia P and Hunter, Kerri and Tossavainen, Helena and Tiwari, Arjun and J{\"a}rvi, Sari and Hellman, Maarit and Aarabi, Fayezeh and Alseekh, Saleh and Wybouw, Brecht and Van Der Kelen, Katrien and Nikkanen, Lauri and Krasensky-Wrzaczek, Julia and Sipari, Nina and Kein{\"a}nen, Markku and Tyystj{\"a}rvi, Esa and Rintam{\"a}ki, Eevi and De Rybel, Bert and Saloj{\"a}rvi, Jarkko and Van Breusegem, Frank and Fernie, Alisdair R and Brosch{\'e}, Mikael and Permi, Perttu and Aro, Eva-Mari and Wrzaczek, Michael and Kangasjarvi, Jaakko},
  issn         = {2050-084X},
  journal      = {ELIFE},
  language     = {eng},
  title        = {Arabidopsis RCD1 coordinates chloroplast and mitochondrial functions through interaction with ANAC transcription factors},
  url          = {http://dx.doi.org/10.7554/elife.43284},
  volume       = {8},
  year         = {2019},
}

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