Advanced search
1 file | 154.85 KB

Short-term and long-term effects of caesarean section on the health of women and children

(2018) LANCET. 392(10155). p.1349-1357
Author
Organization
Abstract
A caesarean section (CS) can be a life-saving intervention when medically indicated, but this procedure can also lead to short-term and long-term health effects for women and children. Given the increasing use of CS, particularly without medical indication, an increased understanding of its health effects on women and children has become crucial, which we discuss in this Series paper. The prevalence of maternal mortality and maternal morbidity is higher after CS than after vaginal birth. CS is associated with an increased risk of uterine rupture, abnormal placentation, ectopic pregnancy, stillbirth, and preterm birth, and these risks increase in a dose-response manner. There is emerging evidence that babies born by CS have different hormonal, physical, bacterial, and medical exposures, and that these exposures can subtly alter neonatal physiology. Short-term risks of CS include altered immune development, an increased likelihood of allergy, atopy, and asthma, and reduced intestinal gut microbiome diversity. The persistence of these risks into later life is less well investigated, although an association between CS use and greater incidence of late childhood obesity and asthma are frequently reported. There are few studies that focus on the effects of CS on cognitive and educational outcomes. Understanding potential mechanisms that link CS with childhood outcomes, such as the role of the developing neonatal microbiome, has potential to inform novel strategies and research for optimising CS use and promote optimal physiological processes and development.
Keywords
SEVERE MATERNAL MORBIDITY, MIDDLE-INCOME COUNTRIES, VAGINAL DELIVERY, PERIPARTUM HYSTERECTOMY, NEONATAL-OUTCOMES, UTERINE RUPTURE, METAANALYSIS, MORTALITY, MODE, PREGNANCY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 154.85 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Sandall, Jane, Rachel M Tribe, Lisa Avery, Glen Mola, Gerard HA Visser, Caroline SE Homer, Deena Gibbons, et al. 2018. “Short-term and Long-term Effects of Caesarean Section on the Health of Women and Children.” Lancet 392 (10155): 1349–1357.
APA
Sandall, J., Tribe, R. M., Avery, L., Mola, G., Visser, G. H., Homer, C. S., Gibbons, D., et al. (2018). Short-term and long-term effects of caesarean section on the health of women and children. LANCET, 392(10155), 1349–1357.
Vancouver
1.
Sandall J, Tribe RM, Avery L, Mola G, Visser GH, Homer CS, et al. Short-term and long-term effects of caesarean section on the health of women and children. LANCET. 2018;392(10155):1349–57.
MLA
Sandall, Jane et al. “Short-term and Long-term Effects of Caesarean Section on the Health of Women and Children.” LANCET 392.10155 (2018): 1349–1357. Print.
@article{8603425,
  abstract     = {A caesarean section (CS) can be a life-saving intervention when medically indicated, but this procedure can also lead to short-term and long-term health effects for women and children. Given the increasing use of CS, particularly without medical indication, an increased understanding of its health effects on women and children has become crucial, which we discuss in this Series paper. The prevalence of maternal mortality and maternal morbidity is higher after CS than after vaginal birth. CS is associated with an increased risk of uterine rupture, abnormal placentation, ectopic pregnancy, stillbirth, and preterm birth, and these risks increase in a dose-response manner. There is emerging evidence that babies born by CS have different hormonal, physical, bacterial, and medical exposures, and that these exposures can subtly alter neonatal physiology. Short-term risks of CS include altered immune development, an increased likelihood of allergy, atopy, and asthma, and reduced intestinal gut microbiome diversity. The persistence of these risks into later life is less well investigated, although an association between CS use and greater incidence of late childhood obesity and asthma are frequently reported. There are few studies that focus on the effects of CS on cognitive and educational outcomes. Understanding potential mechanisms that link CS with childhood outcomes, such as the role of the developing neonatal microbiome, has potential to inform novel strategies and research for optimising CS use and promote optimal physiological processes and development.},
  author       = {Sandall, Jane and Tribe, Rachel M and Avery, Lisa and Mola, Glen and Visser, Gerard HA and Homer, Caroline SE and Gibbons, Deena and Kelly, Niamh M and Kennedy, Holly Powell and Kidanto, Hussein and Taylor, Paul and Temmerman, Marleen},
  issn         = {0140-6736},
  journal      = {LANCET},
  language     = {eng},
  number       = {10155},
  pages        = {1349--1357},
  title        = {Short-term and long-term effects of caesarean section on the health of women and children},
  url          = {http://dx.doi.org/10.1016/S0140-6736(18)31930-5},
  volume       = {392},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: