Opposite subgenual cingulate cortical functional connectivity and metabolic activity patterns in refractory melancholic major depression
- Author
- Guo-Rong Wu, Rudi De Raedt (UGent) , Peter Van Schuerbeek and Chris Baeken (UGent)
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- Project
- Abstract
- Although in treatment-resistant depression (TRD) subgenual anterior cingulate cortex (sgACC) functional connectivity (FC) is frequently used to examine deregulated brain networks, neurobiological data from other sources may be required to interpret these FC findings. In 16 melancholic TRD patients with a high level of treatment resistance and 16 closely matched healthy never-depressed individuals we verified whether sgACC FC patterns were related to regional metabolic activity (CMRglc) with (18)FDG PET imaging. Notwithstanding that TRD patients displayed stronger sgACC FC with the right lateral frontotemporal cortex, metabolically they exhibited the opposite pattern. Our results indicate that the sgACC seed and its functionally connected regions not automatically follow a similar metabolic pattern in TRD, possibly reflecting the refractory state of the sample. Multimodal brain imaging may help to increase our insight into the pathophysiology of TRD.
- Keywords
- DEFAULT-MODE NETWORK, ACCELERATED HF-RTMS, RESTING-STATE, FDG-PET, BRAIN, CORTEX, MRI, MECHANISMS, INSIGHTS, INDIVIDUALS, Major depressive disorder, Refractory, sgACC, Resting state fMRI, (18)FDG PET
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8602922
- MLA
- Wu, Guo-Rong, et al. “Opposite Subgenual Cingulate Cortical Functional Connectivity and Metabolic Activity Patterns in Refractory Melancholic Major Depression.” BRAIN IMAGING AND BEHAVIOR, vol. 14, no. 2, 2020, pp. 426–35, doi:10.1007/s11682-018-0011-1.
- APA
- Wu, G.-R., De Raedt, R., Van Schuerbeek, P., & Baeken, C. (2020). Opposite subgenual cingulate cortical functional connectivity and metabolic activity patterns in refractory melancholic major depression. BRAIN IMAGING AND BEHAVIOR, 14(2), 426–435. https://doi.org/10.1007/s11682-018-0011-1
- Chicago author-date
- Wu, Guo-Rong, Rudi De Raedt, Peter Van Schuerbeek, and Chris Baeken. 2020. “Opposite Subgenual Cingulate Cortical Functional Connectivity and Metabolic Activity Patterns in Refractory Melancholic Major Depression.” BRAIN IMAGING AND BEHAVIOR 14 (2): 426–35. https://doi.org/10.1007/s11682-018-0011-1.
- Chicago author-date (all authors)
- Wu, Guo-Rong, Rudi De Raedt, Peter Van Schuerbeek, and Chris Baeken. 2020. “Opposite Subgenual Cingulate Cortical Functional Connectivity and Metabolic Activity Patterns in Refractory Melancholic Major Depression.” BRAIN IMAGING AND BEHAVIOR 14 (2): 426–435. doi:10.1007/s11682-018-0011-1.
- Vancouver
- 1.Wu G-R, De Raedt R, Van Schuerbeek P, Baeken C. Opposite subgenual cingulate cortical functional connectivity and metabolic activity patterns in refractory melancholic major depression. BRAIN IMAGING AND BEHAVIOR. 2020;14(2):426–35.
- IEEE
- [1]G.-R. Wu, R. De Raedt, P. Van Schuerbeek, and C. Baeken, “Opposite subgenual cingulate cortical functional connectivity and metabolic activity patterns in refractory melancholic major depression,” BRAIN IMAGING AND BEHAVIOR, vol. 14, no. 2, pp. 426–435, 2020.
@article{8602922,
abstract = {{Although in treatment-resistant depression (TRD) subgenual anterior cingulate cortex (sgACC) functional connectivity (FC) is frequently used to examine deregulated brain networks, neurobiological data from other sources may be required to interpret these FC findings. In 16 melancholic TRD patients with a high level of treatment resistance and 16 closely matched healthy never-depressed individuals we verified whether sgACC FC patterns were related to regional metabolic activity (CMRglc) with (18)FDG PET imaging. Notwithstanding that TRD patients displayed stronger sgACC FC with the right lateral frontotemporal cortex, metabolically they exhibited the opposite pattern. Our results indicate that the sgACC seed and its functionally connected regions not automatically follow a similar metabolic pattern in TRD, possibly reflecting the refractory state of the sample. Multimodal brain imaging may help to increase our insight into the pathophysiology of TRD.}},
author = {{Wu, Guo-Rong and De Raedt, Rudi and Van Schuerbeek, Peter and Baeken, Chris}},
issn = {{1931-7557}},
journal = {{BRAIN IMAGING AND BEHAVIOR}},
keywords = {{DEFAULT-MODE NETWORK,ACCELERATED HF-RTMS,RESTING-STATE,FDG-PET,BRAIN,CORTEX,MRI,MECHANISMS,INSIGHTS,INDIVIDUALS,Major depressive disorder,Refractory,sgACC,Resting state fMRI,(18)FDG PET}},
language = {{eng}},
number = {{2}},
pages = {{426--435}},
title = {{Opposite subgenual cingulate cortical functional connectivity and metabolic activity patterns in refractory melancholic major depression}},
url = {{http://dx.doi.org/10.1007/s11682-018-0011-1}},
volume = {{14}},
year = {{2020}},
}
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