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Pre-obese children’s dysbiotic gut microbiome and unhealthy diets may predict the development of obesity

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Abstract
It is widely accepted that the intestinal microbiome is connected to obesity, as key mediator of the diet impact on the host metabolic and immunological status. To investigate whether the individual gut microbiome has a potential in predicting the onset and progression of diseases, here we characterized the faecal microbiota of 70 children in a two-time point prospective study, within a four-year window. All children had normal weight at the beginning of this study, but 36 of them gained excessive weight at the subsequent check-up. Microbiome data were analysed together with the hosts' diet information, physical activity, and inflammatory parameters. We find that the gut microbiota structures were stratified into a discrete number of groups, characterized by different biodiversity that correlates with inflammatory markers and dietary habits, regardless of age, gender, and body weight. Collectively, our data underscore the importance of the microbiome-host-diet configuration as a possible predictor of obesity.
Keywords
CONSUMPTION FREQUENCIES, YOUNG-CHILDREN, INFLAMMATION, MECHANISM, IDEFICS, HEALTH, IMPACT, MILK, FAT

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Chicago
Rampelli, Simone, Kathrin Guenther, Silvia Turroni, Maike Wolters, Toomas Veidebaum, Yiannis Kourides, Dénes Molnár, et al. 2018. “Pre-obese Children’s Dysbiotic Gut Microbiome and Unhealthy Diets May Predict the Development of Obesity.” Communications Biology 1.
APA
Rampelli, S., Guenther, K., Turroni, S., Wolters, M., Veidebaum, T., Kourides, Y., Molnár, D., et al. (2018). Pre-obese children’s dysbiotic gut microbiome and unhealthy diets may predict the development of obesity. COMMUNICATIONS BIOLOGY, 1.
Vancouver
1.
Rampelli S, Guenther K, Turroni S, Wolters M, Veidebaum T, Kourides Y, et al. Pre-obese children’s dysbiotic gut microbiome and unhealthy diets may predict the development of obesity. COMMUNICATIONS BIOLOGY. 2018;1.
MLA
Rampelli, Simone et al. “Pre-obese Children’s Dysbiotic Gut Microbiome and Unhealthy Diets May Predict the Development of Obesity.” COMMUNICATIONS BIOLOGY 1 (2018): n. pag. Print.
@article{8602908,
  abstract     = {It is widely accepted that the intestinal microbiome is connected to obesity, as key mediator of the diet impact on the host metabolic and immunological status. To investigate whether the individual gut microbiome has a potential in predicting the onset and progression of diseases, here we characterized the faecal microbiota of 70 children in a two-time point prospective study, within a four-year window. All children had normal weight at the beginning of this study, but 36 of them gained excessive weight at the subsequent check-up. Microbiome data were analysed together with the hosts' diet information, physical activity, and inflammatory parameters. We find that the gut microbiota structures were stratified into a discrete number of groups, characterized by different biodiversity that correlates with inflammatory markers and dietary habits, regardless of age, gender, and body weight. Collectively, our data underscore the importance of the microbiome-host-diet configuration as a possible predictor of obesity.},
  articleno    = {222},
  author       = {Rampelli, Simone and Guenther, Kathrin and Turroni, Silvia and Wolters, Maike and Veidebaum, Toomas and Kourides, Yiannis and Moln{\'a}r, D{\'e}nes and Lissner, Lauren and Benitez-Paez, Alfonso and Sanz, Yolanda and Fraterman, Arno and Michels, Nathalie and Brigidi, Patrizia and Candela, Marco and Ahrens, Wolfgang},
  issn         = {2399-3642},
  journal      = {COMMUNICATIONS BIOLOGY},
  language     = {eng},
  pages        = {11},
  title        = {Pre-obese children{\textquoteright}s dysbiotic gut microbiome and unhealthy diets may predict the development of obesity},
  url          = {http://dx.doi.org/10.1038/s42003-018-0221-5},
  volume       = {1},
  year         = {2018},
}

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