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Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents : the HELENA study

(2019) PEDIATRIC DIABETES. 20(1). p.23-31
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Abstract
Objective: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness, and sleep with endocrine, metabolic, and immunological health biomarkers in European adolescents. Methods: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5-17.5 years) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Cluster analysis was performed by including body composition, PA by accelerometry, self-reported sedentary behaviors, and sleep duration. We also measured endocrine, metabolic, and immunological biomarkers. Results: Three-cluster solutions were identified: (a) light-PA time, moderate-vigorous-PA time and sedentary time, (b) light-PA time, moderate-vigorous-PA time, sedentary time and sleep time, (c) light-PA time, moderate-vigorous-PA time, sedentary time and body composition. In addition, each cluster solution was defined as: "healthy," "medium healthy," and "unhealthy" according to the presented rating. Analysis of variance showed that overall the healthiest groups from the three clusters analyzed presented a better metabolic profile. A decision tree analysis showed that leptin had a strong association with cluster 3 in both boys and girls, high-density lipoprotein cholesterol had the strongest association with clusters 1 and 3 in boys. Cortisol had the strongest association with cluster 1. HOMA index (homeostatic model assessment) and C3 showed a strong association with cluster 3 in girls. Conclusions: Our results support the existence of different interactions between metabolic health and lifestyle patterns related to PA, sedentariness, and sleep, with some gender-specific findings. These results highlight the importance to consider multiple lifestyle-related health factors in the assessment of adolescents' health to plan favorable strategies.
Keywords
cardiometabolic biomarkers, physical activity, sedentary behavior, sleep time, youth, PHYSICAL-ACTIVITY, SLEEP DURATION, RISK-FACTORS, SEDENTARY BEHAVIOR, SCREEN TIME, CHILDREN, LEPTIN, FITNESS, MARKERS, ADIPOSITY

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MLA
Agostinis‐Sobrinho, César et al. “Lifestyle Patterns and Endocrine, Metabolic, and Immunological Biomarkers in European Adolescents : the HELENA Study.” PEDIATRIC DIABETES 20.1 (2019): 23–31. Print.
APA
Agostinis‐Sobrinho, C., Gómez‐Martínez, S., Nova, E., Hernandez, A., Labayen, I., Kafatos, A., Gottand, F., et al. (2019). Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents : the HELENA study. PEDIATRIC DIABETES, 20(1), 23–31.
Chicago author-date
Agostinis‐Sobrinho, César, Sonia Gómez‐Martínez, Esther Nova, Aurora Hernandez, Idoia Labayen, Antonios Kafatos, Frederic Gottand, et al. 2019. “Lifestyle Patterns and Endocrine, Metabolic, and Immunological Biomarkers in European Adolescents : the HELENA Study.” Pediatric Diabetes 20 (1): 23–31.
Chicago author-date (all authors)
Agostinis‐Sobrinho, César, Sonia Gómez‐Martínez, Esther Nova, Aurora Hernandez, Idoia Labayen, Antonios Kafatos, Frederic Gottand, Dénes Molnár, Marika Ferrari, Luis A Moreno, Marcela González‐Gross, Nathalie Michels, Azahara Ruperez, Jonatan R Ruiz, and Ascensión Marcos. 2019. “Lifestyle Patterns and Endocrine, Metabolic, and Immunological Biomarkers in European Adolescents : the HELENA Study.” Pediatric Diabetes 20 (1): 23–31.
Vancouver
1.
Agostinis‐Sobrinho C, Gómez‐Martínez S, Nova E, Hernandez A, Labayen I, Kafatos A, et al. Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents : the HELENA study. PEDIATRIC DIABETES. 2019;20(1):23–31.
IEEE
[1]
C. Agostinis‐Sobrinho et al., “Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents : the HELENA study,” PEDIATRIC DIABETES, vol. 20, no. 1, pp. 23–31, 2019.
@article{8602887,
  abstract     = {Objective: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness, and sleep with endocrine, metabolic, and immunological health biomarkers in European adolescents.
Methods: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5-17.5 years) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Cluster analysis was performed by including body composition, PA by accelerometry, self-reported sedentary behaviors, and sleep duration. We also measured endocrine, metabolic, and immunological biomarkers.
Results: Three-cluster solutions were identified: (a) light-PA time, moderate-vigorous-PA time and sedentary time, (b) light-PA time, moderate-vigorous-PA time, sedentary time and sleep time, (c) light-PA time, moderate-vigorous-PA time, sedentary time and body composition. In addition, each cluster solution was defined as: "healthy," "medium healthy," and "unhealthy" according to the presented rating. Analysis of variance showed that overall the healthiest groups from the three clusters analyzed presented a better metabolic profile. A decision tree analysis showed that leptin had a strong association with cluster 3 in both boys and girls, high-density lipoprotein cholesterol had the strongest association with clusters 1 and 3 in boys. Cortisol had the strongest association with cluster 1. HOMA index (homeostatic model assessment) and C3 showed a strong association with cluster 3 in girls.
Conclusions: Our results support the existence of different interactions between metabolic health and lifestyle patterns related to PA, sedentariness, and sleep, with some gender-specific findings. These results highlight the importance to consider multiple lifestyle-related health factors in the assessment of adolescents' health to plan favorable strategies.},
  author       = {Agostinis‐Sobrinho, César and Gómez‐Martínez, Sonia and Nova, Esther and Hernandez, Aurora and Labayen, Idoia and Kafatos, Antonios and Gottand, Frederic and Molnár, Dénes and Ferrari, Marika and Moreno, Luis A and González‐Gross, Marcela and Michels, Nathalie and Ruperez, Azahara and Ruiz, Jonatan R and Marcos, Ascensión},
  issn         = {1399-543X},
  journal      = {PEDIATRIC DIABETES},
  keywords     = {cardiometabolic biomarkers,physical activity,sedentary behavior,sleep time,youth,PHYSICAL-ACTIVITY,SLEEP DURATION,RISK-FACTORS,SEDENTARY BEHAVIOR,SCREEN TIME,CHILDREN,LEPTIN,FITNESS,MARKERS,ADIPOSITY},
  language     = {eng},
  number       = {1},
  pages        = {23--31},
  title        = {Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents : the HELENA study},
  url          = {http://dx.doi.org/10.1111/pedi.12802},
  volume       = {20},
  year         = {2019},
}

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