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Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents : the HELENA study

(2019) PEDIATRIC DIABETES. 20(1). p.23-31
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Abstract
Objective: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness, and sleep with endocrine, metabolic, and immunological health biomarkers in European adolescents. Methods: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5-17.5 years) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Cluster analysis was performed by including body composition, PA by accelerometry, self-reported sedentary behaviors, and sleep duration. We also measured endocrine, metabolic, and immunological biomarkers. Results: Three-cluster solutions were identified: (a) light-PA time, moderate-vigorous-PA time and sedentary time, (b) light-PA time, moderate-vigorous-PA time, sedentary time and sleep time, (c) light-PA time, moderate-vigorous-PA time, sedentary time and body composition. In addition, each cluster solution was defined as: "healthy," "medium healthy," and "unhealthy" according to the presented rating. Analysis of variance showed that overall the healthiest groups from the three clusters analyzed presented a better metabolic profile. A decision tree analysis showed that leptin had a strong association with cluster 3 in both boys and girls, high-density lipoprotein cholesterol had the strongest association with clusters 1 and 3 in boys. Cortisol had the strongest association with cluster 1. HOMA index (homeostatic model assessment) and C3 showed a strong association with cluster 3 in girls. Conclusions: Our results support the existence of different interactions between metabolic health and lifestyle patterns related to PA, sedentariness, and sleep, with some gender-specific findings. These results highlight the importance to consider multiple lifestyle-related health factors in the assessment of adolescents' health to plan favorable strategies.
Keywords
cardiometabolic biomarkers, physical activity, sedentary behavior, sleep time, youth, PHYSICAL-ACTIVITY, SLEEP DURATION, RISK-FACTORS, SEDENTARY BEHAVIOR, SCREEN TIME, CHILDREN, LEPTIN, FITNESS, MARKERS, ADIPOSITY

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Citation

Please use this url to cite or link to this publication:

Chicago
Agostinis‐Sobrinho, César, Sonia Gómez‐Martínez, Esther Nova, Aurora Hernandez, Idoia Labayen, Antonios Kafatos, Frederic Gottand, et al. 2019. “Lifestyle Patterns and Endocrine, Metabolic, and Immunological Biomarkers in European Adolescents : the HELENA Study.” Pediatric Diabetes 20 (1): 23–31.
APA
Agostinis‐Sobrinho, C., Gómez‐Martínez, S., Nova, E., Hernandez, A., Labayen, I., Kafatos, A., Gottand, F., et al. (2019). Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents : the HELENA study. PEDIATRIC DIABETES, 20(1), 23–31.
Vancouver
1.
Agostinis‐Sobrinho C, Gómez‐Martínez S, Nova E, Hernandez A, Labayen I, Kafatos A, et al. Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents : the HELENA study. PEDIATRIC DIABETES. 2019;20(1):23–31.
MLA
Agostinis‐Sobrinho, César et al. “Lifestyle Patterns and Endocrine, Metabolic, and Immunological Biomarkers in European Adolescents : the HELENA Study.” PEDIATRIC DIABETES 20.1 (2019): 23–31. Print.
@article{8602887,
  abstract     = {Objective: To evaluate the association of lifestyle patterns related to physical activity (PA), sedentariness, and sleep with endocrine, metabolic, and immunological health biomarkers in European adolescents.
Methods: The present cross-sectional study comprised 3528 adolescents (1845 girls) (12.5-17.5 years) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study. Cluster analysis was performed by including body composition, PA by accelerometry, self-reported sedentary behaviors, and sleep duration. We also measured endocrine, metabolic, and immunological biomarkers.
Results: Three-cluster solutions were identified: (a) light-PA time, moderate-vigorous-PA time and sedentary time, (b) light-PA time, moderate-vigorous-PA time, sedentary time and sleep time, (c) light-PA time, moderate-vigorous-PA time, sedentary time and body composition. In addition, each cluster solution was defined as: {\textacutedbl}healthy,{\textacutedbl} {\textacutedbl}medium healthy,{\textacutedbl} and {\textacutedbl}unhealthy{\textacutedbl} according to the presented rating. Analysis of variance showed that overall the healthiest groups from the three clusters analyzed presented a better metabolic profile. A decision tree analysis showed that leptin had a strong association with cluster 3 in both boys and girls, high-density lipoprotein cholesterol had the strongest association with clusters 1 and 3 in boys. Cortisol had the strongest association with cluster 1. HOMA index (homeostatic model assessment) and C3 showed a strong association with cluster 3 in girls.
Conclusions: Our results support the existence of different interactions between metabolic health and lifestyle patterns related to PA, sedentariness, and sleep, with some gender-specific findings. These results highlight the importance to consider multiple lifestyle-related health factors in the assessment of adolescents' health to plan favorable strategies.},
  author       = {Agostinis\unmatched{2010}Sobrinho, C{\'e}sar and G{\'o}mez\unmatched{2010}Mart{\'i}nez, Sonia and Nova, Esther and Hernandez, Aurora and Labayen, Idoia and Kafatos, Antonios and Gottand, Frederic and Moln{\'a}r, D{\'e}nes and Ferrari, Marika and Moreno, Luis A and Gonz{\'a}lez\unmatched{2010}Gross, Marcela and Michels, Nathalie and Ruperez, Azahara and Ruiz, Jonatan R and Marcos, Ascensi{\'o}n},
  issn         = {1399-543X},
  journal      = {PEDIATRIC DIABETES},
  language     = {eng},
  number       = {1},
  pages        = {23--31},
  title        = {Lifestyle patterns and endocrine, metabolic, and immunological biomarkers in European adolescents : the HELENA study},
  url          = {http://dx.doi.org/10.1111/pedi.12802},
  volume       = {20},
  year         = {2019},
}

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