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Chiral Au I- and Au III-isothiourea complexes : synthesis, characterization and application

(2019) CHEMISTRY-A EUROPEAN JOURNAL. 25(4). p.1064-1075
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Abstract
During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)-isothiourea carbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.
Keywords
bioinorganic chemistry, coordination chemistry, gold, homogeneous catalysis, N ligands, N-HETEROCYCLIC CARBENE, ENANTIOSELECTIVE ALPHA-ALLYLATION, ACETIC-ACID ESTERS, ENAMINE CATALYSIS, PYRIDINE ADDUCTS, GOLD CATALYSIS, STRUCTURAL-CHARACTERIZATION, COOPERATIVE CATALYSIS, SYNERGISTIC CATALYSIS, PROPARGYLIC ALCOHOLS

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MLA
Gasperini, Danila et al. “Chiral Au I- and Au III-isothiourea Complexes : Synthesis, Characterization and Application.” CHEMISTRY-A EUROPEAN JOURNAL 25.4 (2019): 1064–1075. Print.
APA
Gasperini, D., Greenhalgh, M. D., Imad, R., Siddiqui, S., Malik, A., Arshad, F., Choudhary, M. I., et al. (2019). Chiral Au I- and Au III-isothiourea complexes : synthesis, characterization and application. CHEMISTRY-A EUROPEAN JOURNAL, 25(4), 1064–1075.
Chicago author-date
Gasperini, Danila, Mark D Greenhalgh, Rehan Imad, Shezaib Siddiqui, Anum Malik, Fizza Arshad, Muhammad Iqbal Choudhary, et al. 2019. “Chiral Au I- and Au III-isothiourea Complexes : Synthesis, Characterization and Application.” Chemistry-a European Journal 25 (4): 1064–1075.
Chicago author-date (all authors)
Gasperini, Danila, Mark D Greenhalgh, Rehan Imad, Shezaib Siddiqui, Anum Malik, Fizza Arshad, Muhammad Iqbal Choudhary, Abdullah M Al-Majid, David B Cordes, Alexandra MZ Slawin, Steven Nolan, and Andrew D Smith. 2019. “Chiral Au I- and Au III-isothiourea Complexes : Synthesis, Characterization and Application.” Chemistry-a European Journal 25 (4): 1064–1075.
Vancouver
1.
Gasperini D, Greenhalgh MD, Imad R, Siddiqui S, Malik A, Arshad F, et al. Chiral Au I- and Au III-isothiourea complexes : synthesis, characterization and application. CHEMISTRY-A EUROPEAN JOURNAL. 2019;25(4):1064–75.
IEEE
[1]
D. Gasperini et al., “Chiral Au I- and Au III-isothiourea complexes : synthesis, characterization and application,” CHEMISTRY-A EUROPEAN JOURNAL, vol. 25, no. 4, pp. 1064–1075, 2019.
@article{8602814,
  abstract     = {During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)-isothiourea carbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.},
  author       = {Gasperini, Danila and Greenhalgh, Mark D and Imad, Rehan and Siddiqui, Shezaib and Malik, Anum and Arshad, Fizza and Choudhary, Muhammad Iqbal and Al-Majid, Abdullah M and Cordes, David B and Slawin, Alexandra MZ and Nolan, Steven and Smith, Andrew D},
  issn         = {0947-6539},
  journal      = {CHEMISTRY-A EUROPEAN JOURNAL},
  keywords     = {bioinorganic chemistry,coordination chemistry,gold,homogeneous catalysis,N ligands,N-HETEROCYCLIC CARBENE,ENANTIOSELECTIVE ALPHA-ALLYLATION,ACETIC-ACID ESTERS,ENAMINE CATALYSIS,PYRIDINE ADDUCTS,GOLD CATALYSIS,STRUCTURAL-CHARACTERIZATION,COOPERATIVE CATALYSIS,SYNERGISTIC CATALYSIS,PROPARGYLIC ALCOHOLS},
  language     = {eng},
  number       = {4},
  pages        = {1064--1075},
  title        = {Chiral Au I- and Au III-isothiourea complexes : synthesis, characterization and application},
  url          = {http://dx.doi.org/10.1002/chem.201804653},
  volume       = {25},
  year         = {2019},
}

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