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A mechanistic classification of clinical phenotypes in neuroblastoma.

(2018) SCIENCE. 362(6419). p.1165-1170
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Abstract
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. We found that patients whose tumors lacked telomere maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored telomere maintenance mechanisms was substantially worse. Survival rates were lowest for neuroblastoma patients whose tumors harbored telomere maintenance mechanisms in combination with RAS and/or p53 pathway mutations. Spontaneous tumor regression occurred both in the presence and absence of these mutations in patients with telomere maintenance-negative tumors. On the basis of these data, we propose a mechanistic classification of neuroblastoma that may benefit the clinical management of patients.
Keywords
TELOMERASE ACTIVITY, RNA-SEQ, EXPRESSION, MUTATIONS, FREQUENT, MYCN, REARRANGEMENTS, INHIBITION, ACTIVATION, TUMORS

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MLA
Ackermann, Sandra et al. “A Mechanistic Classification of Clinical Phenotypes in Neuroblastoma.” SCIENCE 362.6419 (2018): 1165–1170. Print.
APA
Ackermann, Sandra, Cartolano, M., Hero, B., Welte, A., Kahlert, Y., Roderwieser, A., Bartenhagen, C., et al. (2018). A mechanistic classification of clinical phenotypes in neuroblastoma. SCIENCE, 362(6419), 1165–1170.
Chicago author-date
Ackermann, Sandra, Maria Cartolano, Barbara Hero, Anne Welte, Yvonne Kahlert, Andrea Roderwieser, Christoph Bartenhagen, et al. 2018. “A Mechanistic Classification of Clinical Phenotypes in Neuroblastoma.” Science 362 (6419): 1165–1170.
Chicago author-date (all authors)
Ackermann, Sandra, Maria Cartolano, Barbara Hero, Anne Welte, Yvonne Kahlert, Andrea Roderwieser, Christoph Bartenhagen, Esther Walter, Judith Gecht, Laura Kerschke, Ruth Volland, Roopika Menon, Johannes M Heuckmann, Moritz Gartlgruber, Sabine Hartlieb, Kai-Oliver Henrich, Konstantin Okonechnikov, Janine Altmüller, Peter Nürnberg, Steve Lefever, Bram De Wilde, Frederik Sand, Fakhera Ikram, Carolina Rosswog, Janina Fischer, Jessica Theissen, Falk Hertwig, Aatur D Singhi, Thorsten Simon, Wenzel Vogel, Sven Perner, Barbara Krug, Matthias Schmidt, Sven Rahmann, Viktor Achter, Ulrich Lang, Christian Vokuhl, Monika Ortmann, Reinhard Büttner, Angelika Eggert, Franki Speleman, Roderick J O’Sullivan, Roman K Thomas, Frank Berthold, Jo Vandesompele, Alexander Schramm, Frank Westermann, Johannes H Schulte, Martin Peifer, and Matthias Fischer. 2018. “A Mechanistic Classification of Clinical Phenotypes in Neuroblastoma.” Science 362 (6419): 1165–1170.
Vancouver
1.
Ackermann S, Cartolano M, Hero B, Welte A, Kahlert Y, Roderwieser A, et al. A mechanistic classification of clinical phenotypes in neuroblastoma. SCIENCE. 2018;362(6419):1165–70.
IEEE
[1]
S. Ackermann et al., “A mechanistic classification of clinical phenotypes in neuroblastoma.,” SCIENCE, vol. 362, no. 6419, pp. 1165–1170, 2018.
@article{8601572,
  abstract     = {Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course ranges from spontaneous tumor regression to fatal progression. To investigate the molecular features of the divergent tumor subtypes, we performed genome sequencing on 416 pretreatment neuroblastomas and assessed telomere maintenance mechanisms in 208 of these tumors. We found that patients whose tumors lacked telomere maintenance mechanisms had an excellent prognosis, whereas the prognosis of patients whose tumors harbored telomere maintenance mechanisms was substantially worse. Survival rates were lowest for neuroblastoma patients whose tumors harbored telomere maintenance mechanisms in combination with RAS and/or p53 pathway mutations. Spontaneous tumor regression occurred both in the presence and absence of these mutations in patients with telomere maintenance-negative tumors. On the basis of these data, we propose a mechanistic classification of neuroblastoma that may benefit the clinical management of patients.},
  author       = {Ackermann, Sandra and Cartolano, Maria and Hero, Barbara and Welte, Anne and Kahlert, Yvonne and Roderwieser, Andrea and Bartenhagen, Christoph and Walter, Esther and Gecht, Judith and Kerschke, Laura and Volland, Ruth and Menon, Roopika and Heuckmann, Johannes M and Gartlgruber, Moritz and Hartlieb, Sabine and Henrich, Kai-Oliver and Okonechnikov, Konstantin and Altmüller, Janine and Nürnberg, Peter and Lefever, Steve and De Wilde, Bram and Sand, Frederik and Ikram, Fakhera and Rosswog, Carolina and Fischer, Janina and Theissen, Jessica and Hertwig, Falk and Singhi, Aatur D and Simon, Thorsten and Vogel, Wenzel and Perner, Sven and Krug, Barbara and Schmidt, Matthias and Rahmann, Sven and Achter, Viktor and Lang, Ulrich and Vokuhl, Christian and Ortmann, Monika and Büttner, Reinhard and Eggert, Angelika and Speleman, Franki and O'Sullivan, Roderick J and Thomas, Roman K and Berthold, Frank and Vandesompele, Jo and Schramm, Alexander and Westermann, Frank and Schulte, Johannes H and Peifer, Martin and Fischer, Matthias},
  issn         = {0036-8075},
  journal      = {SCIENCE},
  keywords     = {TELOMERASE ACTIVITY,RNA-SEQ,EXPRESSION,MUTATIONS,FREQUENT,MYCN,REARRANGEMENTS,INHIBITION,ACTIVATION,TUMORS},
  language     = {eng},
  number       = {6419},
  pages        = {1165--1170},
  title        = {A mechanistic classification of clinical phenotypes in neuroblastoma.},
  url          = {http://dx.doi.org/10.1126/science.aat6768},
  volume       = {362},
  year         = {2018},
}

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