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Rethinking Communication in the Immune System: The Quorum Sensing Concept

(2019) TRENDS IN IMMUNOLOGY. 40(2). p.88-97
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Abstract
Quorum sensing was first described as the communication process bacteria employ to coordinate changes in gene expression and therefore, their collective behavior in response to population density. Emerging new evidence suggests that quorum sensing can also contribute to the regulation of immune cell responses. Quorum sensing might be achieved by the ability of immune cells to perceive the density of their own populations or those of other cells in their environment; responses to alterations in cell density might then be coordinated via changes in gene expression and protein signaling. Quorum sensing mechanisms can regulate T and B cell as well as macrophage function. We posit that perturbations in quorum sensing may undermine the balance between diverse immune cell populations and predispose the host to immune abnormalities.
Keywords
REGULATORY T-CELLS, DENDRITIC CELLS, MACROPHAGES, REVEALS, IL-2, PROLIFERATION, HOMEOSTASIS

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Citation

Please use this url to cite or link to this publication:

Chicago
Antonioli, Luca, Corrado Blandizzi, Pal Pacher, Martin Guilliams, and Gyorgy Hasko. 2019. “Rethinking Communication in the Immune System: The Quorum Sensing Concept.” Trends in Immunology 40 (2): 88–97.
APA
Antonioli, L., Blandizzi, C., Pacher, P., Guilliams, M., & Hasko, G. (2019). Rethinking Communication in the Immune System: The Quorum Sensing Concept. TRENDS IN IMMUNOLOGY, 40(2), 88–97.
Vancouver
1.
Antonioli L, Blandizzi C, Pacher P, Guilliams M, Hasko G. Rethinking Communication in the Immune System: The Quorum Sensing Concept. TRENDS IN IMMUNOLOGY. Oxford: Elsevier Sci Ltd; 2019;40(2):88–97.
MLA
Antonioli, Luca et al. “Rethinking Communication in the Immune System: The Quorum Sensing Concept.” TRENDS IN IMMUNOLOGY 40.2 (2019): 88–97. Print.
@article{8601569,
  abstract     = {Quorum sensing was first described as the communication process bacteria employ to coordinate changes in gene expression and therefore, their collective behavior in response to population density. Emerging new evidence suggests that quorum sensing can also contribute to the regulation of immune cell responses. Quorum sensing might be achieved by the ability of immune cells to perceive the density of their own populations or those of other cells in their environment; responses to alterations in cell density might then be coordinated via changes in gene expression and protein signaling. Quorum sensing mechanisms can regulate T and B cell as well as macrophage function. We posit that perturbations in quorum sensing may undermine the balance between diverse immune cell populations and predispose the host to immune abnormalities.},
  author       = {Antonioli, Luca and Blandizzi, Corrado and Pacher, Pal and Guilliams, Martin and Hasko, Gyorgy},
  issn         = {1471-4906},
  journal      = {TRENDS IN IMMUNOLOGY},
  language     = {eng},
  number       = {2},
  pages        = {88--97},
  publisher    = {Elsevier Sci Ltd},
  title        = {Rethinking Communication in the Immune System: The Quorum Sensing Concept},
  url          = {http://dx.doi.org/10.1016/j.it.2018.12.002},
  volume       = {40},
  year         = {2019},
}

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