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Professional and 'Amateur' Antigen-Presenting Cells In Type 2 Immunity

Martijn Schuijs (UGent) , Hamida Hammad (UGent) and Bart Lambrecht (UGent)
(2019) TRENDS IN IMMUNOLOGY. 40(1). p.22-34
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Abstract
Dendritic cells (DCs) are critical for the activation of naive CD4(+) T cells and are considered professional antigen-presenting cells (APCs), as are macrophages and B cells. Recently, several innate type 2 immune cells, such as basophils, mast cells (MCs), eosinophils, and innate type 2 lymphocytes (ILC2), have also emerged as harboring APC behavior. Through surface expression or transfer of peptide-loaded MHCII, expression of costimulatory and co-inhibitory molecules, as well as the secretion of polarizing cytokines, these innate cells can extensively communicate with effector and regulatory CD4(+) T cells. An exciting new concept is that the complementary tasks of these 'amateur' APCs contribute to shaping and regulating adaptive immunity to allergens and helminths, often in collaboration with professional APCs.
Keywords
INNATE LYMPHOID-CELLS, HOUSE-DUST MITE, CD4(+) T-CELLS, PLASMACYTOID, DENDRITIC CELLS, ALLERGIC AIRWAY INFLAMMATION, BARRIER EPITHELIAL-CELLS, CLASS-II COMPLEXES, MAST-CELLS, IN-VIVO, MEDIATED-IMMUNITY

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Citation

Please use this url to cite or link to this publication:

Chicago
Schuijs, Martijn, Hamida Hammad, and Bart Lambrecht. 2019. “Professional and ‘Amateur’ Antigen-Presenting Cells In Type 2 Immunity.” Trends in Immunology 40 (1): 22–34.
APA
Schuijs, M., Hammad, H., & Lambrecht, B. (2019). Professional and “Amateur” Antigen-Presenting Cells In Type 2 Immunity. TRENDS IN IMMUNOLOGY, 40(1), 22–34.
Vancouver
1.
Schuijs M, Hammad H, Lambrecht B. Professional and “Amateur” Antigen-Presenting Cells In Type 2 Immunity. TRENDS IN IMMUNOLOGY. Oxford: Elsevier Sci Ltd; 2019;40(1):22–34.
MLA
Schuijs, Martijn, Hamida Hammad, and Bart Lambrecht. “Professional and ‘Amateur’ Antigen-Presenting Cells In Type 2 Immunity.” TRENDS IN IMMUNOLOGY 40.1 (2019): 22–34. Print.
@article{8601539,
  abstract     = {Dendritic cells (DCs) are critical for the activation of naive CD4(+) T cells and are considered professional antigen-presenting cells (APCs), as are macrophages and B cells. Recently, several innate type 2 immune cells, such as basophils, mast cells (MCs), eosinophils, and innate type 2 lymphocytes (ILC2), have also emerged as harboring APC behavior. Through surface expression or transfer of peptide-loaded MHCII, expression of costimulatory and co-inhibitory molecules, as well as the secretion of polarizing cytokines, these innate cells can extensively communicate with effector and regulatory CD4(+) T cells. An exciting new concept is that the complementary tasks of these 'amateur' APCs contribute to shaping and regulating adaptive immunity to allergens and helminths, often in collaboration with professional APCs.},
  author       = {Schuijs, Martijn and Hammad, Hamida and Lambrecht, Bart},
  issn         = {1471-4906},
  journal      = {TRENDS IN IMMUNOLOGY},
  language     = {eng},
  number       = {1},
  pages        = {22--34},
  publisher    = {Elsevier Sci Ltd},
  title        = {Professional and 'Amateur' Antigen-Presenting Cells In Type 2 Immunity},
  url          = {http://dx.doi.org/10.1016/j.it.2018.11.001},
  volume       = {40},
  year         = {2019},
}

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